Dr Barry durrant peatfield

[dodge1979]

He talks a lot about the 5 deiodinase enzymes

What are they?

[Naomi8]

why not ask him

[dodge1979 in reply to Naomi8]

How do we contact him?

[SeasideSusie Remembering]

I don't think so. We've had no news to that effect.

[Hidden]

You can buy his book on ThyroidUK website thyroiduk.org/ :-

'Your Thyroid and How to Keep it Healthy'

by Dr Barry Durrant-Peatfield

thyroiduk.org/tuk/tuk_shop/...

[humanbean]

To create T3 (the active thyroid hormone) from T4 (produced by the thyroid), one of the iodine atoms must be removed from T4. The numbers in the names T3 and T4 refer to how many iodine atoms each substance has. Different deiodinases are used to convert T4 to T3 or Reverse T3. There are also different deiodinases that do the job in the brain/pituitary and the rest of the body.

To achieve this removal of an iodine atom the deiodinases are required for the job. After the body has used T3 it is converted into T2 and then T1 as a way of eventually removing the thyroid hormone from the body.

For a more scientific (and far more complete and accurate) explanation, this might help :

nahypothyroidism.org/deiodi...

[MaisieGray]

Enzymes are protein molecules in cells which work as catalysts to speed up chemical reactions in the body, but do not get used up in the process. Their names generally end in 'ase' to indicate they are enzymes. Deiodinases regulate the bioavailability of active THs in target tissues: Thyroxine (T4) is a prohormone and must be activated to 3,5,3′-triiodothyronine (T3) by either type 1 (D1) or type 2 (D2) selenodeiodinase, whilst a third deiodinase (D3) inactivates T3 or T4 by removal of an inner ring iodine. Or as Dr P puts it in his book, as T3 gets used up, one of these three 5'-deiodinase enzymes removes one of the four iodine molecules from T4 to convert it into T3. But what can also happen is that one of the other 5'-deiodinase enzymes can remove a different iodine atom which forms reverse T3.