Overdoses of acetaminophen disrupt the thyroid-liver axis in neonatal rats

[helvella]

One of those papers which raises a number of questions. Certainly, high doses of paracetamol, in neonates, is something we might immediately question - but remember how much Calpol is given to very young children.

Endocr Metab Immune Disord Drug Targets. 2019 Feb 12. doi: 10.2174/1871530319666190212165603. [Epub ahead of print]

Overdoses of acetaminophen disrupt the thyroid-liver axis in neonatal rats.

Ahmed RG1.

Author information

1 Division of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Beni-Sue. Egypt.

Abstract

OBJECTIVE:

The objective of the study was to examine the impact of neonatal acetaminophen (APAP; paracetamol) administrations on the thyroid-liver axis in male Wistar rats.

METHODS:

APAP (100 or 350 mg/kg) was orally administered to neonates from postnatal day (PND) 20 to 40.

RESULTS:

Both APAP doses elicited a substantial increase in serum TSH, albumin, AST, ALT, and ALP values, and a profound decrease in serum FT4 and FT3 values at PND 40 relative to those in the control group. Additionally, the hypothyroid state in both APAP-treated groups may increase the histopathological variations in the neonatal liver, such as destructive degeneration, fibrosis, fatty degeneration, fibroblast proliferation, haemorrhage, oedema, and vacuolar degeneration, at PND 40. Moreover, in the APAP groups, a marked depression was recorded in the t-SH and GSH levels and GPx and CAT activities at PND 40 in the neonatal liver compared to those in the control group. However, the levels of hepatic LPO, H2O2, and NO were increased in both APAP-treated groups at PND 40. All previous alterations were dose- dependent.

CONCLUSION:

Neonatal APAP caused a hypothyroidism and disturbed hepatic cellular components by increasing prooxidant markers and decreasing antioxidant markers, causing hepatotoxicity. Thus, neonatal administrations of APAP may act as a neonatal thyroid-liver disruptor.

Copyright© Bentham Science Publishers; For any queries, please email at [e-mail].

KEYWORDS:

Acetaminophen; Antioxidants; Liver; Prooxidants; Rat newborns; Thyroid

PMID: 30760194

DOI: 10.2174/1871530319666190212165603

ncbi.nlm.nih.gov/pubmed/307...

[Heloise]

This drug is dangerous! Over a decade ago I read an article about a man who needed a liver transplant by taking Tylenol and drinking wine and now I tell everyone how dangerous that is. Of course you have to pick your poison. It's either your liver, your kidneys or your stomach depending on your pain drug of choice.

propublica.org/article/tyle...

[helvella Administrator Thyroid UK in reply to Heloise]

Just for clarity (though maybe what it does is confuse ), there are quite a number of products under the Tylenol branding which contain additional active ingredients.

[Hidden]

not surprised.