Blue Horizon DNA Test Results...: Just got my... - Thyroid UK

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Blue Horizon DNA Test Results...

DeniseR profile image
6 Replies

Just got my results back and was wondering if anyone can decipher what they mean?

It seems as though I don’t have an issue with the DI02 gene but there are some other things highlighted.

I’m wondering if these show anything that be worth discussing with an endo, to back up my taking/need for T3?

Any help appreciated, my mind can’t focus today 😩 TIA

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DeniseR
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SlowDragon profile image
SlowDragonAdministrator

Sorry......This photo isn't readable

Some other DNA posts

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

healthunlocked.com/thyroidu...

DeniseR profile image
DeniseR

Sorry, I didn’t realise! I could only post one photo, so tried to squeeze them in. I’ll try posting again. Thanks. I’ll also have a look at the links 😊

DeniseR profile image
DeniseR

I've tried to put all the results here...as you can see, not easy reading. I'm just trying to work out what this means in real/everyday life terms. I think I will email Blur Horizons to try and get clearer explanation too but any help in the meantime would be really appreciated. Thanks :)

Your thyroid genotype and advice:

GENE RESULT IMPACT & ADVICE

AMBER: COMT - Inactivation of Stress Hormones and Oestrogen

COMT is one of the main inactivating enzymes of stress

hormones and oestrogen in the body. COMT variants cause

slow clearance of stress hormones and oestrogen leading to

high oestrogen and stress hormone levels which may also be

linked to thyroid hormone dysfunction. - AG -

Slow clearance of stress hormones and oestrogen. You may

be at increased risk of thyroid dysfunction when under stress

and due to poor elimination of oestrogen.

GREEN & AMBER: DIO1 - Thyroid Hormone Activation

“D1” is largely expressed in the liver and kidneys.

It is

responsible for the clearance of rT3 from circulation, and for

facilitating the conversion of T4 to T3 in plasma and

surrounding tissue. This process requires selenium and iodine

for optimum function. Here we look at two variants linked to

poor conversion of T4 to T3 and reduced clearance of rT3. -CA

-

The 'C' result is associated with increased DIO1 gene function

resulting in rapid conversion of FT4 to T3 and reduced

circulating rT3 levels. Ensure adequate iodine and selenium

intake to support this pathway optimally. - TC

-

Likely to have lower DIO1 activity and therefore probably

decreased clearance of rT3 from circulation, and lower

conversion of T4 to T3. Ensure adequate intake of iodine and

selenium to support this pathway.

GREEN: DIO2 - Thyroid Hormone Activation

“D2” is importantly expressed in the central nervous system,

pituitary, brown fat tissue and muscle, and responds to

changes in thyroid levels. D2 is responsible for the ‘local’

conversion of T4 to T3 in the thyroid, placenta and brain. It

requires selenium and iodine to function optimally. Here we

look at two different variants linked to decreased T4 and low

mood in certain individuals.- TT

-

Linked to normal enzyme activity and not with increased risk

of anxiety and depression if taking thyroxine (T4) hormone

replacement therapy for hypothyroidism -TC-

The 'T' result is associated with increased DIO2 activity. This

has been shown to present as lower T4 and rT3, and higher T3

levels. Adequate levels of iodine and selenium are required

for optimal functioning of this pathway.

GREEN: FKBP5 - Cortisol Regulation

FKBP5 is an important stress-regulating gene responsible for

lowering cortisol levels after a stress response. Variants are

associated with prolonged and increased symptoms of stress,

which may be due to delayed lowering of cortisol levels. -CC-

Healthy cortisol regulation and stress resilience. You are likely

to be less negatively affected by stress and the impact it has

on the body. Thyroid hormone regulation is likely to be less

affected also.

AMBER: PDE8B - TSH Signalling

PDE8B is found in the thyroid but not the pituitary, and is

involved in TSH signalling. It is thought that the variant

decreases the response of the thyroid gland to TSH

stimulation. -GA-

You may be susceptible to reduced thyroid sensitivity to TSH

stimulation which could result in a need for and production of

higher TSH levels in order to produce normal levels of thyroid

hormones (T4 and T3).

GREEN: TNF-a - Inflammation

TNF-a is an inflammatory cytokine that helps regulate the

immune reaction involved in inflammation, giving rise to fever

and inhibiting tumour growth. If poorly controlled, it may be

implicated in a number of autoimmune disorders. Variants in

TNF-a are associated with overreactive immune responses

and prolonged inflammation.- GG-

Not genetically predisposed to overreactive inflammatory

immune response. This means you are less likely to suffer from

chronic inflammation or be at increased risk of developing

autoimmune conditions - including Hashimoto's thyroiditis or

Graves' disease. It is still important for you to manage stress,

and follow a healthy diet and exercise regime to keep your

risk low.

AMBER: TSHR - Thyroid Stimulating Hormone (TSH) Receptor

The TSHR gene plays a central role in thyroid metabolism by

controlling the thyroid gland’s receptivity to TSH. Variants in

this gene have been linked to hyperthyroidism, particularly to

Graves’ Disease (GD).- GA-

The 'A' result has been found to be more common in people

with Graves' Disease and is linked to the presence of thyroid

stimulating hormone receptor antibodies (TRAb), associated

with increased risk of developing GD.

RED: TRHR - Thyrotropin Releasing Hormone (TRH) Receptor

Responsible for the body’s receptivity to TRH which stimulates

the secretion of TSH from the pituitary gland. In turn, TSH

stimulates the production of thyroid hormones from the

thyroid gland. TRH is an important part of the negative

feedback loop that ultimately regulates thyroid hormone

levels. Variants have been shown to affect TSH levels-

GG-

The 'G' result has been associated with a less responsive

negative feedback mechanism. Carriers of this genotype may

show higher circulating TSH:T3/4 ratio due to delayed

reduction of TRH and TSH in the presence of healthy thyroid

hormone levels. This may mean that the body is subjected to

a less efficient response to changing thyroid hormone

requirements.

DippyDame profile image
DippyDame in reply toDeniseR

I had this test done and found the explanations utterly rediculous. It appears that they have tried very hard to simplify the result but have tied themselves in knots instead..

I was only really interested in the D2 result which turned out to be the CC genotype which indicates poor conversion inherited from both parents.

I ended up doing some internet searches in order to make some. sense of it

The following may be useful

healthunlocked.com/thyroidu...

Good luck

Too small to read.

DeniseR profile image
DeniseR

Ok no worries

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