T4 Levo dosage high, (still exhausted with high... - Thyroid UK

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T4 Levo dosage high, (still exhausted with high levels) very recent levels posted, (I know you guys can help you always have great info)

blueabyss
blueabyss

Hi guys this post is for my dear and very uninformed friend who is very exhausted all the time and was prescribed to take 225-250 Levo T4 as she was too low, this is what usually happens, up down /up down levels in each test, constantly exhausted

Could she be absorbing or reacting to the T4 badly? or be possibly reacting to it badly as she has used it for many years

I have have suggested NDT which she is very interested in trialling and i have spoke great stuff about this forum, as it has helped me to wit my issues but for now here are her blood results

*Thyroid FunctionTHYROID STIMULATING HORMONE *0.007 mIU/L 0.27 - 4.20*

*FREE THYROXINE 19.200 pmol/L 12.00 - 22.00

*FREE T3 6.42 pmol/L 3.10 - 6.80

*THYROGLOBULIN ANTIBODY <10 IU/mL 0.00 - 115.00

*THYROID PEROXIDASE ANTIBODIES 26 IU/mL 0.00 - 34.00

Also The doctor said something about her blood sugar being low on the longer term test (Diabetes one?) I had a similar test as I was fine

The doctor said a biscuit and cup of tea will solve it.. can you actually believe that?

kindest regard!

26 Replies
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To add: Also she has the usual other blood tests (which i can post) and it was just the blood sugar the doctor brought up along with the thyroid levels being high

Cheers guys

Thyroid levels are not high, so what was he talking about? I'd want to know B12, folate and ferritin as less than optimal levels of those can cause symptoms. Also eating more fat and fewer carbs to stabilize blood sugar (but it takes time)

Will reply with other blood tests B12/Folate etc asap

I only just realised we can test for cortisol, is blood or urine more accurate?

thanks guys

If you want a GP to take notice it has to be blood test early. But a saliva test is more informative if just for your own use.

Ruoveden
Ruoveden
in reply to blueabyss

Thyroid hormones seem Ok to me.

What about cortisol level?

blueabyss
blueabyss
in reply to Ruoveden

Looking into tests for this now. urine or blood which is the best type

Ruoveden
Ruoveden
in reply to blueabyss

Seems like urine 24h is more reliable than blood, was I told once by gp

Hi

Just, off the top, it looks like

Subclinical hyperthyroidism

Which is the beginning stages

Of Grave's Disease

I would look up Isabella Wentz

She has lots of information about the

Thyroid

blueabyss
blueabyss
in reply to Courtlea

Graves disease? yes the levels are high but so is her dosage 200-225 T4 Levo

The T4 user is taking a high dose of thyroid hormone as she is Hypo for many years and her levels always fluctuate

her dosages have varied but she has felt exhausted and is sleeping far too much as of late

She is seeking more in depth blood tests on her B12, iron ferratin, which weren't done by her lousy GP, so she is getting these done asap and I will update

Also she is going to trial NDT, reason being its free and her body may react to it better, also as there my be a possibility of the regular T4 synthetic meds not being effective or the body reaction is not desirable which is common

Any opinions very much welcome and appreciated

Courtlea
Courtlea
in reply to blueabyss

Well her tsh is very low , that's what makes it hyperthyroidism.

In hypothyroidism her tsh would be high.

Since her thyroid hormones are normal and not high

That makes it subclinical

Thus, subclinical hyperthyroidism

Courtlea
Courtlea
in reply to Courtlea

Also the levo, would most likely supress her tsh

If she wants to feel well , I would try

Lowering the dose of levo to at least under 100

With physician supervision

Once her tsh is in the normal range she may feel better

Then she can adress her other thyroid issues

blueabyss
blueabyss
in reply to Courtlea

hi, did you see that i said she was taking too much T4 at present? she has now reduced them

i understand hypo and hyper (i am borderline hypo so trialed NDT low dose and trialing T4 100mcg at present) T4 for me seems to be working ok for just now, the T3 component in NDT started giving me regular palpitations at low as 1 grain)

she used to take less but her levels were not right so GP as usual increases meds, the latest test reveals these levels, clearly the T4 isnt working even though her levels are too high, thus other bloods and possibly meds are needed

she is getting also other crucial bloods that have been missed

Courtlea
Courtlea
in reply to blueabyss

Sure, but the problem is her thyroid

It is an autoimmune disorder which may

Be either Hashimoto's or Graves Disease

blueabyss
blueabyss
in reply to Courtlea

ok can you explain the antibody levels if you suggest this is autoimmune disorder?

thanks

Courtlea
Courtlea
in reply to blueabyss

Look, I am just trying to help

Courtlea
Courtlea
in reply to Courtlea

I think it is most likely a thyroid issue

and because she has antibodies, ie. 26

This means ( in my opinion) that her thyroid is already making

Antibodies , indicating an autoimmune disorder

It is in the subclinical phase right now

blueabyss
blueabyss
in reply to Courtlea

this is exactly what i said the antibody level of 26. thank you for noticing this

she is going to see another doctor especially with the recent bloods and other tests that are needed. i strongly recommended she sees an experienced endo as GPs are very ignorant to complex thyroid issues

is it also a possibility the T4 levo can be causing this antibody level raised against her thyroid gland (by resistance or a reaction?) if thats what it is and would a medication change possibly change this

views and opinions very welcome

Courtlea
Courtlea
in reply to blueabyss

I think antibodies have nothing to do with the medication

It is happening as a result of thyroid failure

Probably the reason she feels so crappy

blueabyss
blueabyss
in reply to Courtlea

right ok sorry another reply

i understand she went full hypo a long time ago. so her thyroid failing further or having issue is causing this reaction

like you said peoples lives had transformed on NDT

i have that to hand and can start it and start the weaning away from T4. i have the conversion charts so should be fine. i did explain its gradual because of the t3 element and can take several weeks to get the dose near correct as well as feeling well again

thank you again you are a diamond

Courtlea
Courtlea
in reply to blueabyss

I'm not sure, as you know these tests

Can mean diffrent things

I think the medication has pushed her to an almost hyperthyroid state which yes might be the reason why her thyroid is

Producing antibodies.

It might have to do with all the t4 without the t3

To balance it

That is why the NDT is so helpful

She could maybe ask her doctor

For a t3 prescription to go with her t4 prescription

Hope this helps

blueabyss
blueabyss
in reply to Courtlea

of course and i appreciate your help

Courtlea
Courtlea
in reply to blueabyss

This knowledge is just based on my current research

I would also do a full cbc count if you and your friend

Just to make sure there are no abnormalities

Her symptoms though remind me of the

Same symptoms Isabella Wentz described she went

Through when she had Hashimoto's Disease.

There are preventative treatments for this

And the ndt you suggested may help

Best of luck

blueabyss
blueabyss
in reply to Courtlea

ok super info. i appreciate your help i wont see people suffer in silence. i am wise to these conditions but we almost have to force the doctors to help almost

i find many of the older doctors trained overseas in the 60's and 70's and 80's are absolutely useless. so ignorant

younger doctors seem so much smarter and open to condition variations (not always)

Courtlea
Courtlea
in reply to blueabyss

Some doctors know a lot, though most don't

I would look into a few natural therapies

In the meantime

blueabyss
blueabyss
in reply to Courtlea

thank you. all of this is going to be noted

Courtlea
Courtlea
in reply to blueabyss

I think the condition is reversable, good luck

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