Hey guys, I am new here..
I am suffering from constant Fatigue, Depression, Anxiety, Cold sensitivity & Brain fog for past 12 years. It all suddenly started after the episode of Jaundice earlier 2006. Over the time period I have been prescribed with more than 12 antidepressants without any improvements. I no longer take any antidepressants. I am 31 years now.
Earlier this year (2018) I discovered that I have Hypothyroid with High RT3. I also discovered that I have defective gene DIO1 (heterozygous variant) & DIO2 (homozygous variant). So I am unable to convert T4 to T3 at cellular level, although I have good Free T3, Free T4 & TSH blood levels.
Currently I am on 80mcg T3 only treatment to clear RT3. It’s been 6 weeks now and not seen any improvements so far with my symptoms. I gradually increased my dosage to 80mcg over the period of 4 weeks.
Before starting the treatment my RT3 was 31 (Range 9.2−24.1), RT3 levels after 4 weeks of starting the treatment was 17. It went down but I don’t see any improvements with my symptoms.
Please help me to understand if this is normal? How long did it take for you guys to see improvements with your symptoms?