Pregnenolone, is someone using it for "adrenal fatigued" + t3?

[Dawid86]

I am on t3only, due to high rt3. From 5months, i am on 80mcg now, no particular problem on t3, some little improvements, i have very very low morning cortisol, then normal, high, high! Ct3m is not properly working for me . Any experience using pregnenolone +t3? Thanks.

[bahai-dot-org]

Hi.

I use 50 to 100 mg of sublingual pregnenolone in the morning. At night I use DHEA 7 keto to help prevent cortisol surges at night seems to be helping my cortisol in the daytime. I take a hundred and twenty something milligrams of armour thyroid (EW) and 5 micrograms of t3. I had horrible horrible fatigue prior to the pregnenolone and I feel ever so much better now. I was also having symptoms of estrogen dominance ,but the pregnenolone apparently is boosting my progesterone,

so that is subsiding.

YAY PREGNENALONE!!!

[Dawid86 in reply to bahai-dot-org]

Thank you! I was your cortisol on saliva before taking pregnenolone and now?

[bahai-dot-org in reply to Dawid86]

I have no idea. I live in the US and my insurance is very fickle. I judge my cortisol as per the cortisol surges that I would get- they would very rudely awaken me during sleep, and get them in the daytime-feeling like mild anxiety attacks... they're horrible.

so unfortunately I only have anecdotal evidence as per my drastically increased energy and mood and (the dhea7keto has done wonders with limiting or totally eliminating the cortisol surges at night. most of us are estrogen dominant because of all of the xenoestrogens in the environment and food we could all probably use some progesterone to counteract that.

Google "estrogen dominance "and see if any of it sounds familiar.

[BitterSweetS in reply to bahai-dot-org]

Ive had other symptoms of estrogen dominance recently, I keep having heart surges (i didnt think that this could be connected) had a bad one last night. Which I put down to over medicated but now im thinking it could be connected in this way.

Thanks for your comments

[magsyh]

I use natural progesterone because pregnenolone will convert to cortisol. I only use 20mg progesterone daily and that has balanced my hormones and supports my adrenals. No more night time adrenaline rushes. As a man you should only need about 10mg

[Dawid86 in reply to magsyh]

Thank you! I have very low morning cortisol, normal, high, high, on 4 point salivary.. I think to use pregnenolone, i am on t3 only due to high rt3

[JaninaWalker in reply to Dawid86]

If your results are just off kilter for timing it might be due to the time you normally get up. Even if you were to change your schedule for the day of the tests which is what I did when I had my 4 slavia tests done, it could not alter the fact that usually I am on a schedule that matches my best friend and changing it for the day of the tests did not change the output as that was already dependent on my usual schedule.

So my endo, the other doctor who knows more about this, compared to my GP, told me that saliva tests were not good enough to test adrenals and so he ordered an ACTH stimulation test on me to be done in a hospital which took about 2 hours. They measured me over time after an injection to stimulate adrenal output. They take a few different measures over time after the injection. So my endocrinologist said I responded very well to that, so he said I was fine.

So I am making the observation on the fact that your results kind of looked like how my saliva tests looked and it was just because the timing of my day is usually about 8 hours off kilter compare to other people who live a normal normal up during the day and asleep at night type of life which is more usual.

So your results could be similarly OK and only off by timing of your usual sleep pattern, as mine was.

I had to be OFF the extra cortisol my doctor the GP had told me to take, for several weeks before the test as the endo said it had to be my own abilities that were being measured with the ACTH stimulation test and not to have it complicated by extra cortisol having been taken. So I complied with that gladly as I did not like taking cortisol anyway as it made me more angry at the news and other things even when taking it at an occasionally very low dose.

[Angel_of_the_North]

I didn't find it any use (but only had cream). So I take DHEA - sometimes you need to be further up the chain as you can't control what it converts into, but it's worth a try. I'm on T3 only, plus DHEA, progesterone and oestrogen. I have low cortisol at all times - just brushing the bottom of the normal range all day.

[Dawid86 in reply to Angel_of_the_North]

And.. Are you tollerating t3?

What about t3 dosing/timing?

Are you using ct3m to support adrenals?

Did you have some kind of improvement using dhea/progesteron about your cortisol situation?

[Angel_of_the_North in reply to Dawid86]

I have been on T3 only for a lot of years. I used to have such low cortisol that any physical stress would have me lying on the ground vomiting, unable to get up. But apparently no tumour. Now I can dig the garden and do a day's work. My cortisol is still low normal but I have some genetic problem with pituitary and hypothalamus. I did ct3m for a year or so, but can't be arsed to wake up in the middle of the night any more, so I take T3 3 times a day starting at about 6 am

[minus in reply to Angel_of_the_North]

How did you find out that you had a pituitary problem? I'm wondering the same about my health.

[Angel_of_the_North in reply to minus]

Low TSH, low free t4 and low free T3, plus low sex hormones. But could be problem with hypothalamus also

[OneLeggedTeddyBear]

I’m on 100mg t3 and 100mg levothyroxine. Is anyone in the uk on pregnenolone? What tests did you ask doctor for? I believe my adrenals are damaged by past surgery.

[OneLeggedTeddyBear]

Sorry I’m new here!!! How can I get pregnenolone please? Tell me if I’m invading your thread x

[SeasideSusie Remembering in reply to OneLeggedTeddyBear]

To get responses you will need to start your own thread, your question wont be seen tucked on the end of someone else's.

As it is a prescription only medication, you should be seeing your doctor about this. What makes you think you need pregnenolone?

If you are trying to get it without prescription then your post will have to be closed and any information sent by private message only.

[OneLeggedTeddyBear in reply to SeasideSusie]

Sorry and thank you. I’m not trying to get it without prescription. I have underactive thyroid and could sleep all day most days. But I also have depression, anxiety and I believe my adrenals were damaged by kidney surgery. My doctor just looks at my blood results and says they’re fine but I feel fatigued all the time. Do you think pregnenolone or DHEA will help me?

[SeasideSusie Remembering in reply to OneLeggedTeddyBear]

OneLeggedTeddyBear

Not a problem, I know you've only started posting today. It's just that when you have a specific question, rather than a commenn on someone else's thread, it wont get seen when it's tacked onto the other thread. Your own thread with an appropriate title will be seen by everyone and those who can help will respond, but wont necessarily see your question in someone else's thread.

If you start a new thread and give information and test results (include reference ranges), say what thyroid meds (and any other meds and supplements you take) we can respond appropriately. Depression, anxiety, fatigue - all symptoms of hypothyroidism, so you may not be optimally medicated. If you don't have your results, in the UK we are legally entitled to them so just ask at your surgery's reception desk for a print out. Don't accept verbal or hand written results as mistakes can be made, make sure it's a print out and it should include the reference ranges so check that they're there - either at the side or often in brackets, eg: TSH 2.5 (0.27-4.20)

Also, testing nutrient levels is very useful. These need to be optimal for thyroid hormone to work so it's a good idea to test

Vit D

B12

Folate

Ferritin

If you think you may have damage to adrenals from the kidney surgery, you really should be checked out, possibly referred back to follow this up.

I have no idea if pregnenolone or DHEA will help, they're not really something that one can try just to see if it helps, they're serious medications and used incorrectly may cause problems.

Hopefully your new thread will get the attention of members who may have experience with this

[OneLeggedTeddyBear in reply to SeasideSusie]

Thank you for all your advice. I don’t have a current print out of my bloods so that’s on my list of jobs to do. I have told the hospital about my suspected Adrenal damage, they did a blood test for Cortisol which came back ok. Thanks again

[SeasideSusie Remembering in reply to OneLeggedTeddyBear]

OneLeggedTeddyBear

Did you get the result of the Cortisol test?

For a full picture of free cortisol plus DHEA you can do a 24 hour adrenal saliva test, which tells us much more than the blood test.

This is the one I use

thyroiduk.org/tuk/testing/r...

I did one yesterday, samples in the freezer ready to send tomorrow.

[OneLeggedTeddyBear in reply to SeasideSusie]

Yes I got the Cortisol results which were just in range. I’ve read about the saliva test but my anxiety messes with my concentration and ability to do anything.

[SeasideSusie Remembering in reply to OneLeggedTeddyBear]

I can't interpret cortisol blood tests so if you make a new thread to ask for comment on your result then those who know about them will respond.

There is nothing to the saliva test, you just fill a little tube with some spit (small straw provided), 4 times during the day, takes me about 5 minutes to do the first one in the morning, and about 3 minutes to do the others.

[bahai-dot-org in reply to OneLeggedTeddyBear]

In in the US one can obtain bioidentical progesterone and pregnenolone over the counter. doctors do not corner the market on on my body. I can usually intuit what's going on, it's invariably verfied by PCP.

I was crushed when I found out about the insidious codex thing you guys have over there... Probably about the same way you all feel about our orange-faced tyrannical leader...."it's always somethin'"-Rosanna Rosannadanna (SNL)

[Dawid86 in reply to SeasideSusie]

What do you think about the use of pregnenolone to help adrenals.? Thank you

[SeasideSusie Remembering in reply to Dawid86]

It's not something I would self treat with, my opinion is that it should be done under a practioner's guidance.

[Dawid86 in reply to SeasideSusie]

Of course under guidance! I like your opinion based on what you saw in your experience

[SeasideSusie Remembering in reply to Dawid86]

I have never taken pregnenolone or DHEA so can't give any comment from my own experience.

[bahai-dot-org in reply to Dawid86]

I find it to be extremely effective the sublingual variety especially

[bahai-dot-org in reply to OneLeggedTeddyBear]

I buy bio-identical progesterone on Amazon. but I think Codex made it so EU has to get these types of things through prescription?

Can someone please clarify? I'm fairly ignorant as per world events-I eschew the news... otherwise, I risk vaporized adrenals....🙀

[TangoMang]

Hi, I also have reverse t3 issues and unable to convert t4. Was wondering if you are on brand name liothyronine or generics. I also experienced a higher cortisol in the evening compared to the am. Since the half life of T3 is so short I was wondering if the pregnenolone would assist me in the morning when my cortisol levels are lower. Seems at around about hour five after 10mcq of t3 my heart rate increases etc, which I was attributing to arise in cortisol since the t3 would be dissipating. Thyroid removed 19 years ago. Have tried the t4(felt horrible), tried most of the dissicated out there from Armour to Nature thyroid to Erfa. All of them work okay for awhile but eventually fail. Not so happy with the Phizer shortage or the expense. Generics seem to be stepped on. Wondering if the pregnenolone would help or if I should go straight to hydrocortisone and at what dose.