Predictive factor of Thyroglobulin in cancer

[Nanaedake]

An interesting article on the predictive factor of thyroglobulin (not to be confused with thyroglubulin antibodies, TgAb) and distant metastasis in patients with differentiated thyroid cancer.

nature.com/articles/s41598-...

[jgelliss]

Nanaedake

Great article and thank you for bringing Tg to the for front . I had TT for papillary cancer and my Tg is always checked . The Endo /Dr likes to see <1 results . However when on NDT it might rise by some patients since NDT has some Tg from the porcine .

[Nanaedake in reply to jgelliss]

That's useful to know about NDT. Thanks, mine is always around 6 but in my case apparently not a problem so long as it doesn't rise.

[SilverAvocado in reply to jgelliss]

Jgekliss, this post is great timing for me, as I'm going through this very problem right now. I've had a TT for follicular cancer, and now 5 years later have a raised thyroglobulin.

But I'm also taking a pretty whopping dose of NDT right now. A pharmacologist friend has calculated my blood test shows about 1 2,000th of the thyroglobulin I am taking. Looks like there may be LOADS in NDT relative to the amount a thyroid produces, and the half life is decent, 60hours or something.

Do you have any more information about this? I would really appreciate any links. But not sure this is discussed in a straightforward way anywhere?

[jgelliss]

SilverAvocado

I know that many thyroid patients on NDT go off of NDT two weeks prior running labs and switch to synthetic T3 . NDT will give you a higher Tg results on your labs . Mine is usually <1 and now it went up a bit . I'm on a low dose NDT .