Thyroglobulin

[posthinking01]

Can anyone tell me what a high amount of this protein means - range listed 40 - mine is 1621 !

[Charlie-Farley]

Hi posthinking

It's one of the antibodies produced as a result of active Hashimoto's. I had a quick gander at you past posts and noted you have had high TPO antibodies too in the past.

Have you got any recent blood test results with ranges to put into context? And IMPORTANTLY how are you feeling. Have you been poorly or is something else flared up? I noticed you are also on the lupus support group too.

[helvella Administrator in reply to Charlie-Farley]

Not necessarily.

Both thyroglobulin and thyroglobulin antibodies can be tested.

Thyroglobulin Test

Formal Name

Thyroglobulin (Tg)

labtestsonline.org.uk/tests...

Thyroid Antibodies

Also Known As

Thyroid autoantibodies

Anti-thyroid antibodies

Anti-microsomal antibody

Thyroid microsomal antibody

Thyroid peroxidase antibody

TPOAb

Anti-TPO

Thyroid binding inhibitory immunoglobulin TBII

Antithyroglobulin antibody

TgAb

TSH receptor antibody

TRAb

Thyroid stimulating immunoglobulin

TSI

Formal Name

Thyroid peroxidase antibody (TPOAb); Thyroglobulin antibody (TgAb); Thyroid stimulating hormone receptor antibody (TRAb)

labtestsonline.org.uk/tests...

[posthinking01 in reply to helvella]

Hi both replies - I had over 7000 I think they were TPO antibodies- now thyroid burned out and noticed this result from 2022 when TPO ab’s dropped from 1,000 to 50 and was assumed the autoimmune response against thyroid has ceased - but …… saw this today on the system and didn’t connect this is a different antibody and can be linked to thyroid cancer - awaiting 24 Jan an up to date result - I have been losing weight 34 pounds rapidly so bit concerned now I have seen the lab description as to why test is asked for - I suspect celiac and am now GF.

[posthinking01 in reply to helvella]

Hi thanks for this useful info and for taking time to reply - there are so many aren’t there ?

[helvella Administrator in reply to posthinking01]

I just hope two things:

1) It has been helpful;

2) It doesn't turn out for the worst.

[posthinking01 in reply to Charlie-Farley]

Yes have had issues but feel very well gluten free had tried GF years ago and didn’t agree with me - but had bowel issues last August all tests so far showing all ok apart from waiting for endoscopy to do biopsy for celiac - I am loving the automatic weight loss as went from 8.5 stone to 16 stones when thyroid went out and nothing would shift it !

[Hibs1 in reply to posthinking01]

You should not go gf till the endoscopy results. You could get a false negative

[posthinking01 in reply to Hibs1]

Yes i know and I have to go back to gluten for two weeks before procedure- not looking forward to that !

[Hibs1 in reply to posthinking01]

It's usually 6 weeks for the gluten challenge as per Coeliac uk

[posthinking01 in reply to Hibs1]

Well consultant said 2 weeks !

[Hibs1 in reply to posthinking01]

I would check because you could get a false negative In the biopsies. How long have you been gf?

[posthinking01 in reply to Hibs1]

I have found that 6 weeks was recommended previously but not any longer 2 weeks will suffice apparently

[Hibs1 in reply to posthinking01]

That's incorrect. I would phone coeliac UK.

[buddy99]

Have you had an ultra sound of your thyroid? From what I understand nodules can come with high thyroglobulin. Or do you have high TgAb? Anyway, I found this research paper: ncbi.nlm.nih.gov/pmc/articl...

"Thyroid nodules are usually accompanied by elevated thyroglobulin (Tg) level and autoimmune thyroid diseases (AITDs). However, the relationship between Tg and AITDs is not fully understood. Dysfunction of regulatory T cells (Tregs) plays an important role in the development of AITDs."

Hope that helps and that nothing more serious is afoot.

[posthinking01 in reply to buddy99]

Thank you for kind time in trying to help - I did have an ultrasound of my thyroid last year and it was shown it had atrophied - but think I might have celiac disease but failed a confirmatory blood test - only way now is biopsy via endoscopy- I am going to query the high results for this antibody in case it means something other than hashi’s which I have.

[buddy99 in reply to posthinking01]

I'm relieved to see that it's high antibodies and not high thyroglobulin. That is most likely less serious and somewhat common for hashi's. Will you have the endoscopy, then, to see if you have celiac? I had the antibodies for celiac and declined the endoscopy, but I was going to start a gf diet anyway, since it also seems to be beneficial for some people with hashi's. I wish you all the best.

[joydot in reply to posthinking01]

Celiac testing is a joke. My daughter & I both have it & number of neg tests were obscene. V few medics use good ones. Her German specialist is excellent, the nhs is trying to kill me. I have ord & she had thyroid cancer age 20.

[posthinking01 in reply to joydot]

I agree so sorry to hear you having trouble - I have lost 37 lbs in weight and failed blood test but hopefully endoscopy will find the antibodies via a biopsy - problem I now have is - I think I am malabsorbing my thyroid meds and steroids for Addisons - the forums for Cealiac knew meds could be lost via malabsorption but my Drs didn’t know !