Currently I’m on T3-only after unsuccessful T4-only, and T4+T3 mix trials over 18 months. While I’m waiting on the compounding chemist to get in touch with my endo, who is travelling on the other side of the world, so they can fill my script for NDT (they can’t read his handwriting!!) I’ve decided to try out Marsaday’s suggestion of a half-tablet (10mcg in Australia, our standard tablets are 20mcg) at 4am, then my usual 4 lots of 20mcg at 8am, 12midday, 4pm and 8pm. Total 90mcg. Day 2 today and feeling okay, possibly improved. Aaaggrr! I dread writing yes I actually do feel better, because those improvements always seem to fade after a few days for me. But... yesterday I felt sooo well in the morning, I forgot to take my 12midday until 1:30! I felt good, some energy, body pain near zero with paracetamol (normally it just dulls the pain; it’s always still there) and clear-headed, articulate and sharp for at least 4 hours - bliss! So... day 2 today. See how we go. Anyone else out there had success with T3 circadian?