My current total dose of T3-only is 80mcg. A week ago I started taking 10mcg at 4am, then 20mcg at 8am, 12midday, 4pm and 8pm — 90mcg in total. I’d been doing various versions of the multi-dose for a few months. I felt noticeably better for 2 days (placebo...or...?) and then knocked down again this weekend just gone. Exhausted. I wonder if my relatively low-stress receptionist job keeps me going during the week, then I just crash on the weekend... not every weekend though. Anyway! Main point of this blog is that I’m trying this method from today. Took 80mcg at 4am; I do it in my sleep (hmm... sort of and getting back to sleep is getting easier. I was worried I’d have a stroke or heart attack but one of the “oldies” here kindly shared some articles and interviews with me and —given I’m STILL waiting for my NDT script and STILL feeling rubbish, I thought why not? Benefits of this method so far: 1) middle of the night guarantees empty stomach and no issues with coffee, tea or supplements. 2) no multiple alarms throughout the day reminding me to take my next dose and, by the way, reminding me that I’m one unwell woman. I do feel self-conscious having to pop pills all day! 3) less stress about possibly forgetting to take my meds to work (it happens) and what if they’re not stored in the fridge (they weren’t at work; just too hard) and what if...? All okay now because my meds are safe at home, in the fridge, until the night before I take them, when my 4 tablets are by my bed for 4am. 4) I can drink coffee and tea throughout the day guilt-free yayyy!! Thanks to the lovely one who suggested this (I don’t want to lose my blog by checking your name now... you know who you are and... is there anyone else using single dose T4, T4/T3, T3 or NDT ? And how are you finding it works for you?