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Thyroid UK
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Thyroid - high uric acid - gout?

Hi guys

I wanted to explore what could be causing my gout?

I have elevated uric acid, pain in my big toe, knees and hands

The only possible cause I can see is thyroid, as ive mentioned previously on this site my mum and sister are both hypothyroid and I have all the symptoms

Bloods are as follows

TSH 2.58

T4 16.4 (11-24pmol)

T3 4.3 (3.90-6.80pmol)

13 Replies

According to this :


hypothyroidism can cause high levels of uric acid, yes. And, you are on the verge of hypo. Not diagnosed or treated, I take it?


Gout can also run in families where it's related to a relatively poor clearance of uric acid.

I know of men who've been diagnosed with RA who eventually had the diagnosis change to pseudogout or calcium pyrophosphate deposition (CPPD) disease that was accidentally discovered during a change of diet: healthline.com/health/pseud...

CPPD is also associated with hypothyroidism as it seems that hypo. very early changes are associated with changes throughout the body long before the hypothyroidism is flagrant.


Are you in the UK or US?

If you are in the UK you are going to have to ask posters to PM you with health professionals who will treat you with TSH and free T4 at that those levels as the majority of health professionals will refuse to treat you even privately.


Not being treated at the moment

I also have bad psoriasis which I developed in last few years

Im going to force my doctor to put me on T3 as I cant cope with the chronic fatigue anymore I fall asleep at my desk at 9am


IF you've got psoriasis, have you been throughly assessed for psoriatic arthritis as a differential for the gout?

Ahead of the results of the medication review, in most parts of the UK, GPs can't prescribe T3 without an endocrinologist advising it - have you had a referral to endocrinology for the thyroid?

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No I haven't been assessed for PA - but had my uric acid drawn lots

I am under care of endo yes at the London endocrinology clinic

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Do you also have high thyroid antibodies? You need to know. Did GP or Endo ever test these? If not ask that they are tested.

Likely as you have Psoriasis another autoimmune disease, plus Mum and sister already have it

Low vitamins that affect thyroid are vitamin D, folate, ferritin and B12. When they are too low they stop Thyroid hormones working.

Ask GP to test and always make sure you get the actual results and ranges

If your antibodies are high this is Hashimoto's, (also known as autoimmune thyroid disease). About 90% of hypothyroidism in UK is due to Hashimoto's.

Hashimoto's very often affects the gut, leading to low stomach acid, low vitamin levels and leaky gut. About 5% are coeliac, but over 80% of us find gluten free diet helps significantly. Either due to direct gluten intolerance (no test available) or due to leaky gut and gluten causing molecular mimicry (see Amy Myers link)

But don't be surprised that GP or endo never mention gut, gluten or low vitamins. Hashimoto's is very poorly understood

Changing to a strictly gluten free diet may help reduce symptoms.







Thanks so much for your reply - Ive had Hashi test and was told it was normal

B12 was 424


What was the actual Hashimoto's antibodies test result

We have had plenty on here bern told result was negative/normal when it definitely wasn't

B12 - need the range - usually about 210-680.

Plus need to loook at in conjunction with folate. They work together

Vitamindtest.org.uk - £28 postal kit



I was told the range was 200-2000 for b12 but I think this was a typo?

I don't have the hashis result unfortunately - is it quite common they say normal when it is not the case?


I'll answer you with an example. A common blood test done by doctors is ferritin (iron stores). In the UK a common reference range for ferritin is :

13 - 150 ug/L

If you have 3 patients - A, B, and C - with results as follows :

A : 13 ug/L

B : 85 ug/L (i.e. roughly mid-range)

C : 150 ug/L

all three patients will be told their results are normal.

In some cases results of 8 or 10 upwards will be called "normal" too, because the attitude is that the result is "close enough".

But ask yourself, which one of these patients is likely to feel best. The answer is B. The one who feels worst is likely to be A, and they may feel better if they got their ferritin result higher. This isn't guaranteed by the way - there is a lot more to iron testing than just a ferritin level, so supplementing shouldn't be done just on the basis of a ferritin level - but I'm only using it as an example.

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I have now just been diagnosed via ultrasound with an enlarged spleen

Is this related to thyroid


HI guys I have just run my temp today 3pm uk time and it is coming back at 36.3?

Is this a big indicator of a problem


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