Confused any advice

[Deanna5326]

Hi I have had such a mixture of symptoms initially went to the GP with symptoms of extreme tiredness, itchy skin , weight gain , frequent urination

Bloods taken

TSH 0.05 range 0.35-5.50

T4 15.4 range 12.0-22.0

Serum vit B12 375ng/l range 180-914

Serum folate 12ng/l range 3.0-20.0

Thyroid peroxidase 507iu range 0.0-60.0

The following week became agitated /panicky insomnia severe headaches . GP commenced carbimazole 5mg and repeated bloods

TSH 0.48

T4 16.9

T3 4.4 range 3.10-6.80

So carbimaziole stopped GP spoke to endo consultant stared Propanolol 80mgfor continued anxiety feelings

For past month unable to sleep longer than 2 hours strange sensations when lye flat and trying to get to sleep , feel as if I wake up with a startle.

See consultant for first time next week

Any advice grateful

[SlowDragon Administrator]

High thyroperoxidase antibodies (TPO) is indicative of Hashimoto's, or autoimmune thyroid disease - basically hypothyroid. But in early stages we can swing from hypo to hyper

Your GP seems to have confused it with Graves' disease

Read as much as possible about Hashimoto's. Hashimotos commonly affects our digestive system leading to low vitamin levels

Before seeing endocrinologist Ask GP to test vitamin D, folate, ferritin and B12. Common that these are too low

Low Vitamin D can be linked to poor sleep

drgominak.com/sleep/vitamin...

[Deanna5326 in reply to SlowDragon]

Thankyou

[humanbean]

How long were you actually on carbimazole for?

Neither of the sets of results you've given show any evidence of hyperthyroidism. All the Free T4 and Free T3 results you've given are below mid-range. If you were truly hyperthyroid these would have been high.

The fact that you've had these low in range results AND your TSH is low in range make me wonder if your pituitary is capable of producing sufficient TSH for your needs.

However, there are other possible explanations for the results you had. You may have been just coming out of a Hashi's flare. The positive result for TPO (Thyroid Peroxidase) Antibodies shows that you have Hashimoto's Thyroiditis (known to patients as Hashi's). I don't know whether you knew you had this but there is no doubt. I've described what this means in practice in the third reply to this post :

healthunlocked.com/thyroidu...

There is another thing to consider. A lot of people who have thyroid issues develop low or high cortisol. There is a lot of overlap in symptoms between these two conditions, and amongst them is anxiety, depression, panic, palpitations, fast heart rate, insomnia, weight changes. Also, with high cortisol there are effects on the thyroid - TSH is lowered and conversion from T4 to T3 is impaired. (I'm not so knowledgeable on low cortisol symptoms.)

The propranol you've been prescribed may make you feel better temporarily, but they are not good for your thyroid and they don't cure the underlying condition (assuming your cortisol levels are wacky).

The best test of cortisol levels is saliva testing. This can only be carried out privately at your own expense. If you decide to do the test, once you have the results you can post them and ask for feedback.

I think this test is the best one because it includes a test of DHEA along with cortisol :

gdx.net/uk/product/adrenal-...

Read the Description/Analytes/Requirements and the Additional Resources. The current price without Thyroid UK discount is £85, but the discount reduces this to £77.

For info on how to order the test (Genova deal with the public as little as possible), see this link :

thyroiduk.org.uk/tuk/testin...

[Deanna5326 in reply to humanbean]

Thankyou I only took the carbimazole for 4 days however the second set of bloods were taken prior to taking any carbimazole.

Thanks for advice

[Deanna5326]

Seen by endocrinologist today he says I'm perimenopause and this explains my symptoms not sure how it explains positive antibodies though