Another in what now appears to be my never-ending series of posts about use of T3 in areas other than endocrinology.
Exp Toxicol Pathol. 2017 Jun 8. pii: S0940-2993(17)30260-9. doi: 10.1016/j.etp.2017.05.010. [Epub ahead of print]
A study on role of triiodothyronine (T3) hormone on the improvement of articular cartilage surface architecture.
Jia PT1, Zhang XL1, Zuo HN1, Lu X1, Gai PZ2.
1 Department of Orthopedics, Yantaishan Hospital, Yantai, 264000, China.
2 Department of Joint Surgery, Yantai Yuhuangding Hospital, 264000, China. Electronic address: firstname.lastname@example.org.
The present study was aimed to investigate the effect of triiodothyronine (T3) on the improvement of articular cartilage surface architecture at in vitro level. The T3 hormone was applied to neo-tissues in the range of 50, 100, 150 and 200ng/ml for 5 weeks. At the end of the treatment, biochemical and histological evaluation was carried out in the neo-tissues. T3 hormone application significantly increased the collagen production in neo-cartilage tissues. The properties of tensile and compressive were significantly increased compared to the controls. However, T3 hormone application also induced hypertrophy. At the higher dose concentration of T3 hormone application, tensile and compressive properties were tremendously increased 4.3 and 4.6 fold respectively. Taking all these data together, it suggested that the T3 hormone application could be a potential agent to increase the functional properties such tensile and compressive in neo-tissues.
Copyright © 2017 Elsevier GmbH. All rights reserved.
Cartilage; Compressive; Neo-tissues; Tensile; Thyroid hormone
[ Edited 20:18 14/06/2017 to correct pubmed link and add sciencedirect link. ]