A study on role of triiodothyronine (T3) hormone on the improvement of articular cartilage surface architecture

Another in what now appears to be my never-ending series of posts about use of T3 in areas other than endocrinology.

Exp Toxicol Pathol. 2017 Jun 8. pii: S0940-2993(17)30260-9. doi: 10.1016/j.etp.2017.05.010. [Epub ahead of print]

A study on role of triiodothyronine (T3) hormone on the improvement of articular cartilage surface architecture.

Jia PT1, Zhang XL1, Zuo HN1, Lu X1, Gai PZ2.

Author information

1 Department of Orthopedics, Yantaishan Hospital, Yantai, 264000, China.

2 Department of Joint Surgery, Yantai Yuhuangding Hospital, 264000, China. Electronic address: gaipengzhou@hotmail.com.


The present study was aimed to investigate the effect of triiodothyronine (T3) on the improvement of articular cartilage surface architecture at in vitro level. The T3 hormone was applied to neo-tissues in the range of 50, 100, 150 and 200ng/ml for 5 weeks. At the end of the treatment, biochemical and histological evaluation was carried out in the neo-tissues. T3 hormone application significantly increased the collagen production in neo-cartilage tissues. The properties of tensile and compressive were significantly increased compared to the controls. However, T3 hormone application also induced hypertrophy. At the higher dose concentration of T3 hormone application, tensile and compressive properties were tremendously increased 4.3 and 4.6 fold respectively. Taking all these data together, it suggested that the T3 hormone application could be a potential agent to increase the functional properties such tensile and compressive in neo-tissues.

Copyright © 2017 Elsevier GmbH. All rights reserved.


Cartilage; Compressive; Neo-tissues; Tensile; Thyroid hormone

PMID: 28602390

DOI: 10.1016/j.etp.2017.05.010



[ Edited 20:18 14/06/2017 to correct pubmed link and add sciencedirect link. ]

17 Replies

Thanks for this. I am racked with tendon, bone and joint problems despite taking NDT perhaps I need some extra T3?

I wouldn't like to convert an experimental research observation into a change of treatment!

But I do understand why anyone would ask that question. Just wish I had even an inkling of how to answer it.

Yes and remember this is engineered tissues and as they are forming, if I understand correctly lol????, which means not tissues grown already and no involvement from the rest of the body which may serve to counteract lol :-)

Might explain why my daughter was able to hold her head up at birth and why she was in a door frame baby bouncer five weeks later though lol ;-)


Thanks helvella it was posed hypothetically given the remoteness of the study 😊

Yes - I assumed as much, but wanted to be clear for anyone else!

helvella seems I am getting the right T3 from what Panda321 points out below 😊

Panda321 and I have disagreed before about this.

I believe that the T3 molecules in your bloodstream are identical whether they come from a pig, cattle or a laboratory.

As a recent post of mine made clear, there are impurities in synthetic thyroid hormones. There might be differences about the delivery (i.e. there is one chemical difference, and how it dissolves and is transported into the bloodstream), but once there it is absolutely 100% identical.

helvella it would explain why we can take animal thyroxine and it works for us. I guess it is like a lock and key at the point it gets across to all our cells so it must be the same to open the lock and get through or it is some sort of skeleton key. That is how I see it anyway but I am no scientist just a visual thinker. I could be visualising nonsense.

I am perfectly happy with the idea that, for reasons that are not entirely clear, at least some people do better on desiccated thyroid than synthetic (whether T4, T3 or any combination). Though we must not miss the observation that some people do better on synthetic.

The fact that the desiccated thyroid contains a whole load of thyroglobulin and other substances is well known and accepted.

What I do not accept is that, once in the bloodstream, where most of it will get bound to our own binding proteins, there is any difference whatsoever.

Further, we can think through the fact that many thyroid hormone tests rely on the same sort of lock and key approach in laboratory tests. If the "key" quality of synthetic thyroid hormone were different to that of "real" thyroid hormone, we could expect it not to fit the lock of the immunoassay.

helvella I wonder if anyone has studied how accurate the lock and key has to be i.e. Can slightly different molecules get through or is it a complete filter for anything different.I am assuming it is at a molecular level this stuff is happening. Your post implies it has to be the same to get through. It is quite mind blowing really. Why did they make chemistry such a bore at school?

I presume everybody realises that it is NOT the synthetic T3 (liothyronine) that is the subject of this study, it is one of the the natural components of NDT (triiodothyronine).

It is a great shame that both of these products are referred to as T3 as they jolly well are NOT the same despite what anybody may say, even the manufacturer of Armour NDT, SPS contractor to the NHS, endocrinologists and any other "expert" you care to mention.

If they were identical then the man-made product could never be patented and could not even be licensed, as NDT itself is not licensed.

Really interesting! Thanks!

Panda321 That is very interesting. Is the NDT T3 superior do you think to the synthetic T3? I wonder if they extracted T4 from NDT how much it might differ from levothyroxine.

Of course the natural product, triiodothyronine, will be better than the synthetic chemical, liothyronine, for the vast majority of those who can no longer produce any of their own. There will, of course, always be exceptions as thyroid diseases cannot ever be lumped together, they are individual to each person. BUT, it is never going to be a product you can actually buy.

Likewise natural "T4", Tetraiodothyronine , would be better than the synthetic chemical, levothyroxine sodium. BUT you will never be able to get it as it would not be capable of being patented and Big Pharma would certainly not want that! (No $£¥€).

But what, for Heaven's sake, is the point of isolating them when what the patient actually needs is every one of the multitude of hormones that is present in natural NDT???? Just because the doctors do not know what a specific lesser hormone does, does not give them any right to say that it is not required by the human body. Do they know better than GOD? - I think not!!!

There is an article on the website of the TPA which shows how different the natural product is to the inferior synthetic copy. It is also available from the website of Thyroid-S:


I imagine that the isolated natural hormones are available to those in the medical world already based on the fact that HUMAN NDT can be purchased there if it is needed for medical research.

Panda321 thanks for you really informative reply. I feel nature has a considerable head start on scientists by some billions of years and I am gobsmacked by their arrogance when, like you say, they don't understand something they just label it superfluous to need as if our bodies would waste energy on making things of no use to us. I find NDT infinitely superior to two dimensional levothyroxine I felt like a half alive zombie on it but feel pretty much me on NDT certainly 3D again so there are important things in it that my body cannot get from synthetic T4.

Human NDT...how do they get that - donation of bodies to medical science? Can't think how else.

Thank you for reply. I must emphasise that I have no medical training whatsoever. Everything I say is based entirely upon my own personal experiences and upon what I have read online from both fake medical "experts" and from genuine experts, the sufferers themselves. I do have a professional qualification, however, as a Chartered Accountant!

Years ago I would have believed the entire opposite. You really must suffer from thyroid problems in order to become 100% convinced that the medical "industry" is totally corrupt regarding this issue. I could not have previously believed that I would have become so infuriated at the insane medical treatment that would be offered to me when I lost my thyroid gland would force me to write the following to the local Area Prescribing Committee after they informed me of a further delay to answering my complaint:


I do believe you are trying to antagonise me. Your continued delay of a proper answer which has true meaning rather than the repetition, parrot-fashion, of the utterly INSANE recommendations of the RCP, the BTA and the Society for Endocrinology does not exactly please me. You must certainly be fully aware how ridiculous these recommendations actually are. To take levothyroxine, the "gold standard" synthetic hormone rather than the natural Thai NDT I now am forced to buy for myself, would condemn me to permanent illness, probably confined to bed, for the rest of my life, just like I had up to 3 years ago.


It's not just me - there are THOUSANDS of patients in this region who need NDT and most of them have no idea how to get it or even that they actually need it. Many of them will be taking expensive prescription drugs to combat the hypothyroid symptoms from which they suffer. Any other drug will NOT, of course, cure their problems, as NDT is NOT a drug - it is a combination of essential NATURAL hormones, and the human body needs every one of them!


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