Does this paper really imply we could argue like this:
"Doctor, Please let me have my liothyronine so that when I have a stroke, it will be mild rather than moderate."
Of course, far, far better would be if getting liothyronine in an appropriate dose actually meant no stroke at all. What do you think? After all, thyroid and inflammation are already deeply intertwined.
Clin Chim Acta. 2016 Apr 22. pii: S0009-8981(16)30148-6. doi: 10.1016/j.cca.2016.04.023. [Epub ahead of print]
Low triiodothyronine: A new facet of inflammation in acute ischemic stroke.
Ma L1, Zhu D2, Jiang Y1, Liu Y1, Ma X1, Liu M1, Chen X3.
1Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, PR China.
2Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, PR China; Department of Neurology, Shenzhen Second People's Hospital, PR China.
3Department of Neurology, The Third Affiliated Hospital, Sun Yat-sen University, PR China. Electronic address: email@example.com.
Patients with acute ischemic stroke (AIS) frequently experience low free triiodothyronine (fT3) concentrations. Inflammation is recognized as a key contributor to the pathophysiology of stroke. Previous studies, however, did not simultaneously evaluate fT3 and inflammation biomarkers in AIS patients.
Markers of inflammation, including serum concentrations of C-reactive protein (CRP) and albumin, and fT3 were assessed retrospectively in 117 patients. Stroke severity was measured on the National Institutes of Health Stroke Scale (NIHSS). Regression analyses were performed to adjust for confounders.
Serum fT3 concentrations were significantly lower in moderate AIS patients than those in mild AIS patients (P<0.001). fT3 concentration also positively correlated with serum albumin concentration (r=0.358, P<0.001) and negatively correlated with log10CRP concentration (r=-0.341, P<0.001), NIHSS score (r=-0.384, P<0.001). Multiple regression analysis showed that CRP, albumin concentrations and NIHSS score were independently correlated with fT3 concentration. Binary logistic regression analysis showed that fT3 concentration was an independent factor correlated with NIHSS score, the area under the receiver operating characteristic curve was 0.712 (95% CI, 0.618-0.805).
Low fT3 concentrations may be involved in the pathogenic pathway linking inflammation to stroke severity in AIS patients.
Copyright © 2015. Published by Elsevier B.V.
Albumin; C-reactive protein; Inflammation; Stroke; fT3
[PubMed - as supplied by publisher]