You are hypothyroid but that's easy, just take a little pill every day...
188,813 papers on PubMed that refer to "thyroid", and we still have researchers talking about "shed new light" and "novel insights" because they fully accept that there is much yet to be found out.
Pharmacol Ther. 2017 Feb 4. pii: S0163-7258(17)30026-8. doi: 10.1016/j.pharmthera.2017.02.012. [Epub ahead of print]
New Insights into Thyroid Hormone Action.
Mendoza A1, Hollenberg AN2.
1Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
2Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. Electronic address: firstname.lastname@example.org.
Thyroid hormones (TH) are endocrine messengers essential for normal development and function of virtually every vertebrate. The hypothalamic-pituitary-thyroid axis is exquisitely modulated to maintain nearly constant TH (T4 and T3) concentrations in circulation. However peripheral tissues and the CNS control the intracellular availability of TH, suggesting that circulating concentrations of TH are not fully representative of what each cell type sees. Indeed, recent work in the field has identified that TH transporters, deiodinases and thyroid hormone receptor coregulators can strongly control tissue-specific sensitivity to a set amount of TH. Furthermore, the mechanism by which the thyroid hormone receptors regulate target gene expression can vary by gene, tissue and cellular context. This review will highlight novel insights into the machinery that controls the cellular response to TH, which include unique signaling cascades. These findings shed new light into the pathophysiology of human diseases caused by abnormal TH signaling.
Copyright © 2017. Published by Elsevier Inc.
Sadly, the full paper is behind a high paywall.