Triiodothyronine ameliorates silica-induced pulmonary inflammation and fibrosis in mice

[helvella]

One of the recurring themes in thyroid medicine is the use of thyroid hormone, most particularly T3, for purposes other than obvious and direct thyroid hormone replacement in those who are hypothyroid.

Sci Total Environ

. 2021 May 26;790:148041.

doi: 10.1016/j.scitotenv.2021.148041. Online ahead of print.

Triiodothyronine ameliorates silica-induced pulmonary inflammation and fibrosis in mice

Meng Yang 1 , Dongming Wang 2 , Shiming Gan 2 , Bin Wang 2 , Linling Yu 2 , Yujia Xie 2 , Lieyang Fan 2 , Jixuan Ma 2 , Weihong Chen 3

Affiliations

• PMID: 34090168

• DOI: 10.1016/j.scitotenv.2021.148041

Abstract

Environmental exposure to silica or particles is very common in natural, agricultural and industrial activities. Chronic silica exposure can lead to silicosis, which remains one of the most serious interstitial lung diseases all through the world, while viable therapeutic choices are restricted. Triiodothyronine (T3) has been shown to exert a defensive role in many pulmonary diseases, however, rare data are available regarding the role of T3 on silica-induced injury. We constructed an experimental silicosis mouse model and T3 was intraperitoneally administrated after instillation of silica to observe the effect of T3 on silica-induced lung inflammation and fibrosis. Our results showed that the silicosis mouse model was accompanied by changes in thyroid morphology and function, and T3 supplement reduced silica-induced lung damage, inflammation and collagen deposition. The protective properties of T3 on silica-induced lung injury could be partially mediated through thyroid hormone receptors. And the mechanism by which T3 treatment ameliorated silica-induced fibrosis appeared to be via the reduction of glycolysis. Also, T3 could sufficiently postpone the progression of pulmonary fibrosis in established silicosis. Our findings reveal that administration of T3 could down-regulate the inflammatory response, pulmonary fibrosis and other lung damage caused by silica. The reduction of glycolysis may be one of the mechanisms.

Keywords: Glycolysis; Inflammation; Pulmonary fibrosis; Silica; Triiodothyronine.

pubmed.ncbi.nlm.nih.gov/340...

[LindaC]

Fascinating - thank you, helvella!

[TSH110]

Poor mice

[tattybogle in reply to TSH110]

Yes .. i wish they'd stop doing horrible things to innocent mice to see what T3 does....and just give us a disclaimer to sign and experiment on us and ask us if we feel better afterwards rather than disecting mices.... Shame we can't get Endo's to experiment on themselves...... of course they'd have to be thyroidectomised first ..... ha! ha! ha!

helvella .. another Nice Find ..... i wish i had something intelligent to say about it , but i don't.. other than the observation that you re doing really well this week at improving my vocabulary and sending my eyes funny with long words in italics...

"....intraperitoneally administrated...."

[jgelliss]

Helvella Thank you for bringing us another great finding . I agree with tattybogle . I and many others would not mind to be the lab rats when it comes to T3 /NDT. Let the thyroid patients decide what works well and what does not. Further more they should make sure that thyroid meds are of the best and purest quality less fillers/dyes and T3/NDT that are reliable and work well .

[Ellie-Louise]

I wonder if there will be changes to the way some animals are treated now that there is, or soon will be a law that animals are sentient beings. My memory isn’t allowing me to remember whether that recent change to the law has been passed yet or not.

[Tythrop in reply to Ellie-Louise]

Ref the "law", after over 30 years in the business I'm thinking of having Tshirts printed saying this:-"You can have as many laws enacted as you like, but if you dont have people/a budget for ENFORCEMENT you might as well have no law" Sorry, this is my little soap box.

[Ellie-Louise in reply to Tythrop]

theguardian.com/world/2021/... 👍

[Tythrop]

I am very interested in this subject as I understand that there is a link between inflamation and clinical depression , so maybe T3 supplinents could help with that too. Any info on this subject greatefully received.

[tattybogle in reply to Tythrop]

T3 has long been used successfully in cases of 'treatment resistant depression' by psychiatrists.. and psychiatrists as well as Endocrinologists have authority to prescribe T3 for this purpose. ncbi.nlm.nih.gov/pmc/articl... Liothyronine for Depression: A Review and Guidance for Safety Monitoring

[holyshedballs]

it seems that the Chinese researchers are not as bound to the TSH/reference range biases as UK/USA researchers. very interesting about the silicosis angle, the pulmonary angle and the inflammation angle.