Slowly, so very slowly, evidence is accumulating that the impact of thyroid hormone is far more complicated than turning the wick up - or down - a bit.
(Although many peope have claimed the T2 content of desiccated thyroid is responsible for some of its impact, I tend to the view that the amount present is likely so small as to have virtually no impact. I could be wrong. Even if I am, no-one controls the amount of T2 that is present so it really could vary quite a bit.)
Mol Cell Endocrinol. 2017 Feb 9. pii: S0303-7207(17)30092-8. doi: 10.1016/j.mce.2017.02.012. [Epub ahead of print]
Direct and rapid effects of 3,5-diiodo-L-thyronine (T2).
Moreno M1, Giacco A1, di Munno C1, Goglia F2.
1Department of Science and Technologies, University of Sannio, Benevento, Italy.
2Department of Science and Technologies, University of Sannio, Benevento, Italy. Electronic address: email@example.com.
A growing number of researchers are focusing their attention on the possibility that thyroid hormone metabolites, particularly 3,5-diiodothyronine (T2), may actively regulate energy metabolism at the cellular, rather than the nuclear, level. Due to their biochemical features, mitochondria have been the focus of research on the thermogenic effects of thyroid hormones. Indeed, mitochondrial activities have been shown to be regulated both directly and indirectly by T2-specific pathways. Herein, we describe the effects of T2 on energy metabolism.
Copyright © 2017. Published by Elsevier B.V.
3,5-Diiodothyronine; Energy metabolism; Metabolic rate; Mitochondria; Short-term effects; Thyroid hormone action