Hi can anyone tell me how I am supposed to take Omeprazole when I take Thyroxine. The doctor who gave it to me said "I dont care when you take it",.. but to be honest I feel worse than I did before taking it, I was given it for nausea in the mornings, i have a Hiatus Hernia. So I am guessing that it isn't working as I am taking it before lunch four hours after Thyroxine and I think you are supposed to take it before breakfast which cant because of the Thyroxine. Any suggestions would be appreciated. Also does anyone else feel much worse on this or is it a side effect that will pass?