last August i had a knee operation. I was prescribed Tramadol for the pain, took the pain away, during that time I went out for a meal, didn't take my meds that day, so i had a glass of wine, woke up the following day (with what I know now to be) an opiate smell..... The 4th of October I realized I didn't have any pain, so I stopped the Tramadol, and of course I went into a heavy withdrawal, the doctor never told me to cut down, and I didn't know the tablets were that strong. Eventually I went back to the Doctors, and they put me on Sertraline, I went even worse on these tablets, I thought i was going crazy, very bad anxiety. I looked on the internet for the interaction between thyroxine and Sertraline and the interaction was very bad, so I stopped them after 14 days, they have now put me on Matazapine , first he put me on 7.5ml for 2 weeks after 14 days put me on 15ml, I am still feeling bad depression after 5 weeks, his intention is to get me to 45ml, I actually don't feel much better on the 15ml than I did taking 7.5 still very depressed and have anxiety during the day, can't socialize, feel all there doing for me is helping me to sleep and maybe eat a bit better, still not eating as well..... I am existing not living... I am afraid to up the dose, as I was better taking 7.5ml, still didn't help me really..I feel antidepressants and thyroxine don't go together... I have also found out recently that I was taking too much thyroxine, as again I was given Calcium, they upped my thyroxine to compensate, cos there is an interaction, because of everything I was going through, I stopped the Calcium, for many months, my thyroid went over, now I think I am taking the right dose 75micro...... this is what I was taking before my knee op and before I took calcium, basically when i was okay..... So I really don't know, whether the Tramodol ( which incidentally I still have that opiate smell now and then) or it's thyroxine and antidepressants that don't go together... I am totally confused and in a bad way.... please help!!