My friend and pharmacist also has hypothyroidism which has been unsuccessfully treated with t4 only. She always looked tired, her skin was dry and dull, her hair was dry thin and dry and she was over weight. Well I piped in to see her concerning irritated eye treatments and straight away I noticed a huge difference. She looked so much younger, fitter and brighter around the eyes. So I mentioned ndt and had she taken some but she said no, she doesn't eat anything or any part of any animal but her endo had changed her meds to t3 only. She hadn't improved with t4 and was taking a high dose so that's how she got the t3. I was unsure about all this t3 and t4 but now I've seen the difference a change of prescription makes. Me I'm waiting for an appointment referral to see specialist and hopefully I will feel and look well too, fingers crossed.