Hi, I have had Hashi's for most of my life and for a long time was on Levo only and losing arguments with various GPs about its ineffectiveness for me. Just over a year ago I got a referral to a new Endo who discovered that my thyroid is now pretty much non-existent and put me on 75mcg Levo and 20mcg Liro. My labs last May were FT4 11.5, FT3 5.2 and TSH 0.14 which he was happy with (as long as my TSH did not fall below 0.1) and I felt really good on this dosage for about 12 months. Then this May I was hit by an awful bout of depression and brain fog, called my GP for a blood test and a week later got FT4 (10.3) and TSH (0.09) done but the symptoms were already abating by the time of the test. They peaked when I had my period which is when I asked for the test; my hormones when I am on my period effect my thyroid and cause chaos if I am not feeling great. Since then I have been on a rollercoaster of hype/hyper symptoms (insomnia/extremely tired, nauseous and lightheaded/faint, with swelling in my limbs, palpitations, looser bowels, brain fog, inability to string words together and could eat everything in sight, which is not me at all!) which come and go on a daily basis and are severe enough to effect work and my ability to drive some days. I had a scheduled blood test with the Endo in June and the results were: FT4 14.4, FT3 9.6 and TSH 0.02. I obviously have far too much T3 in my system but I am not sure on how to adjust the dosages that I am on the alleviate the problem. My prescription is up for renewal today, my GP refuses to discuss a new dosage, though I am hoping they will at least renew it! The hospital where my Endo works runs a Virtual Clinic system and I can't see him before Sept anyway; his PA is fabulous and she was a great help last week in having me referred to their committee yesterday for discussion but she made it clear that she can only be able to come back to me when she has something to tell me and I have nudged her once but do not want to upset the relationship that I have built with her. If she doesn't come back today the earliest I will hear from her is next Wednesday and I don't want to carry on like this another week or more. I am still on 75/20 but am seriously thinking about adjusting it myself if someone could help me with the maths?! Oh, the reference ranges for my tests are FT4 12.0-22.0, FT3 3.1-6.8 and TSH 0.27-4.20. Thank you!