Drug-gene testing should be mandatory - IMO

Seriously, how much time and money it would save if we were tested before given any medication?

I know it would be hard to get insurance companies to agree with this as genetic testing could be costly and they would probably try to demand all the data for the future use. In the future they would probably deny some people getting an insurance based on possible risk of getting cancer or so.

Still I say it would be major thing in health care saving money and lives. Not just benefiting patients but doctors too. It would make health care much more effective and smooth.

Basically any drug can be tested, like my dad was tested if he would be suitable to get biological / cancer medication for his psoriasis because for example cancer medication can collapse your lungs. My dad was suitable for that medication and has been on it for 2 years without any troubles except he has to get certain flu injections and pneumonia injection, pneumonia could be fatal in his case.

But this would also benefit people who are given antidepressants, there are tests available, but rarely those are ordered. Imagine how much time and money that would save? If person would need ad's, they would immediately know which medication to give, less side effects and harmful symptoms. I know ad's are bad, but using correctly those could work. Recommended time period for ad's is 3-6 months.

Even pain killers can be tested, how simple it would be then to get correct medication instead of going through tons of different type of medication suffering from nasty symptoms.

Of course, genetic testing does not mean that the drug wouldn't be harmful, but if you cannot metabolize given medication whats the point to take it?

I say it would save lives and money to do drug-gene testing.

2 Replies

  • justina

    I don’t think it is just  the drugs which need testing, it could be a number of things that cause a reaction e.g   a patient’s inability to metabolise the drug,  also  drug interactions also comes into question.

    Maybe the following links will provide a very small insight into the enormous problems of  adverse drug reactions:-

    •    New Prescription Drugs: A Major Health Risk With Few Offsetting Advantages

    Few people know that new prescription drugs have a 1 in 5 chance of causing serious reactions after they have been approved. That is why expert physicians recommend not taking new drugs for at least five years unless patients have first tried better-established options, and have the need to do so. ethics.harvard.edu/blog/new...

    •    Thyroid UK  ----  click on thyroiduk.org.uk/tuk/testin...   it will provide you with information on testing for  the DIO2 (Deiodinase 2 Gene) Genetic Test.   Quote:- "Common Variation in the DIO2 Gene Predicts Baseline Psychological Well-Being and Response to Combination Thyroxine Plus Triiodothyronine Therapy in Hypothyroid Patients" by V Panicker, P Saravanan, B Vaidya, J Evans, A Hattersley, T Frayling & C Dayan

    •    BSACI guidelines for the management of drug allergy   (The Standards of Care

    Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI) state: --- “considerable experience is required for the investigation of allergic drug reactions and to undertake specific drug challenge. A missed or incorrect diagnosis of drug allergy can have serious consequences. Therefore, investigation and management of drug allergy is best carried out in specialist centres with large patient numbers and adequate competence and resources to manage complex cases.)    bsaci.org/

    •    Dr Shuaib Nasser, Consultant Allergist, Addenbrooke’s Hospital, Cambridge and Chair of the Guideline Development Group, said:  “Wrongly prescribing drugs to people with known allergies puts them at serious risk of harm but we know this can be avoided. It is important that this is done, as some allergic reactions can be fatal.

  • Drug-gene testing is about whether you can metabolise it or not.   

    Allergies indeed are another factor but that is a different story, important tho as one might have to pull some tricks to find suitable medication. 

    Another thing is gut bacteria.  It is known that people with certain bacteria do not react well to paracetamol which can cause liver damage. That is worrying especially when people take paracetamol hangover.  

    Genes causing diseases like DI02(if you can call poor conversion a disease) is another important factor indeed.  It seems there are upto 50 genes that affect thyroid function.  Maybe testing all should be procedure when suspecting thyroid issues.  If all tests were available of course.   That would make it far more easier to find a fix for each individual!

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