Thyroid UK
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Methylation pathways

Does anyone here know anything about methylation pathways ? I am looking at my snps and found a lot were tagged with yasko method. Individually I've seen some that interfere with b12, vit d, and folate. So much more work to do. I'm particularly looking at whether these mutations might affect usage of the vitamins, etc that are in the blood (I.e. blood looks normal or elevated but body is insufficient because it can't use it well ).

Any info would be very helpful.

B/r. Jen

9 Replies

Chrystalheart, not something I'm familiar with but there's heaps about it on Google


Thanks clutter. I have been hitting Google hard


Well good luck, Chrystalheart, it doesn't look like an easy topic to grasp.


Hello Chyrstalheart,

I had the DetoxiGenomic Profile and results showed I have polymorphisms

on certain genes. My gene GSTM1 is totally absent and so affects the liver and kidney and therefore I supplement Glutathione. Also gene SOD2 which protects the mitochondria from oxidation carries one variation, so I now supplement Co Q10. There were others but I can't remember as a nutritionist interpreted the results and advised on sups.

Identifying the risk of chemical sensitivities, oxidative stress and the ability to handle various medications due to synps, allows us to avoid exposer thereby reducing the risk of getting disease and illness that might be genetically predispositions to have in later life .....and also supplementing nutrients that our body naturally has trouble metabolising.

I also have 50 -60% reduction in MTHFR enzyme activity but have Haemochromotosis (iron overload) and HIGH B12 which led me to the same question as you were asking...?? ........."...had the "active B12 blood test" (holotranscobalamin) which again showed high levels of a B12. ! ! !

Some people suggest that measuring methylmalonic acid (MMA) is more reliable....some say it is not sensitive enough.

Others suggest an assessment of B12 status in practice ........depression, impaired balance, anxiety, neuropathy, red blood cells size count MCV), Hematocrit, homocysteine, and functional immunoassays.

I suffer from a bad taste in a very dry mouth, tinnitus and neuropathy in my feet ...indicating a B12 deficiency. I supplement with Seeking Health B Complex

Plus which contains active forms of folate, vitamin B12, riboflavin, B6, B vitamin cofactors shilajit extract (providing fulvic acid), choline, the active form of folate, 5-methyltetrahydrofolate (5-MTHF), is included to help ensure an immediate response on metabolism compared to synthetic folic acid, the form commonly found in other supplements. 5-MTHF is especially useful for supporting neurological system requirements as it is the only form of folate that crosses the blood-brain barrier.

Dr Ben Lynn who runs the MTHFR website at

The link below is quite interesting

This link below explains the importance of vitamins and where they may be obtained.

This forum is supported by the charity ThyroidUK. You do not have to join the charity to benefit from this forum but by doing so you will be supporting the charity and also entitled to various discounts when buying supplements, as detailed in the link.



Thank you flower! I'm going to get my genetic genie results today and am in the processing of mapping my snps that weren't on snpmedia to other sites for info.



SYN's in MTHFR variations are very common and lead to B12 and folate deficiencies.

I forgot to say...I had head problems ( ..not depression but weird whooshy feelings & dizziness after starting Levothyroxine..) which have improved dramatically. I don't know whether this was due to the addition of T3 to my thyroid meds or 5-MTHF that as explained above is the only form of folate that crosses the brain barrier.

I was really excited about all in another thread Clutter pointed out the dangers of over supplementing folate so ensure to have your results read correctly.

I think it great to have these tests done as although our DNA is our biochemical destiny, it gives us the ability to improve that path with support for epigenetics and methylation through correct diet, supplementation and lifestyle.

As you already know there are plenty of sites available to interpret your methylation patterns but all at a cost. Below is a link to a book that is being recommended on Facebook pages for referencing individual SNP's, including methylation MTHFR varients and its associated pathways. It is expensive but if you are researching individual SNP's, I guess the book could end up cheaper in the long run.

Please note that I do not have this book and haven't seen it as used a nutritionist to interpret my results.

Good luck Crystalheart,



I found several free sites: for methylation n detox panels, n

Also for $5 you can get the promethease tool which offers disease to mutation mapping for your genome.


Great news Chrystalheart,

You can save your dosh for all those supplements you will need to buy on realising your SNP'



So true... Lol

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