My endocrinologist switched me from T4 only to T3+T4 combination therapy 6 weeks ago and I wanted to ask others who've taken T3+T4 whether my experience is normal.
I previously was on 150 mcg levothyroxine which was enough to suppress TSH completely, with my T4 in the upper half of the range and my T3 about half way through the range. I had all the usual persistent symptoms. I was switched to 100 mcg levothyroxine and 10 mcg liothyronine. Endocrinologist said the goal was to increase my T3 levels but try to keep my TSH detectable.
For the first week I felt no difference, then in the second and third weeks the change was noticeable. I had so much more energy that I was going into work earlier in the morning (currently only working half days because of thyroid), and going for long walks after work. I felt so much more positive and people commented that I was looking better. My skin, nails etc were still terrible but I didn't expect that to change very quickly. However, at week 4 I noticed a downward slump and in the past two weeks I've been feeling more and more tired in the morning/after work, unable to concentrate etc etc. Twice this weekend I had the dreaded freezing cold legs and have started wearing long johns again under my trousers (in summer...). Is it normal to experience a short high period, presumably when T3 is building up, but then to slump again a few weeks later, presumably by which point the levels of T4 (and T4 converting to T3) are starting to fall off? Has anybody else experienced this when starting with T3?
I emailed my endo this morning asking to increase the T3, and he said to get my TSH, T4 and T3 levels checked again so he can see what's going on. Booked a blood test for tomorrow so hopefully that will help interpret things.