If anyone can explain this to me, please do!
The reason for posting is to highlight that there is research going on which might, eventually, help us to understand and, dare I suggest?, treat autoimmune disorders at the level of their cause.
Autoimmun Rev. 2015 May 16. pii: S1568-9972(15)00112-3. doi: 10.1016/j.autrev.2015.05.004. [Epub ahead of print]
Emerging role of long non-coding RNAs in autoimmune diseases.
Wu GC1, Pan HF1, Leng RX1, Wang G2, Li XP3, Li XM3, Ye DQ1.
1Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China; Anhui provincial laboratory of population health & major disease screening and diagnosis, Anhui Medical University, 81 Meishan Road, Hefei, 230032, Anhui, China.
2Department of Nephrology, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui, China.
3Department of Rheumatology and Immunology, Anhui Provincial Hospital, Affiliated to Anhui Medical University, 17 Lujiang Road, Hefei 230001, Anhui, China.
Long non-coding RNA (lncRNA), with size larger than 200 nucleotides, is a new class of non-coding RNA. Emerging evidence has revealed that lncRNAs play a key role in the regulation of immunological functions and autoimmunity. Herein, we review the recent findings of lncRNA regulation in immune functions and in the development of autoimmunity and autoimmune disease. In addition, we focus on the involvement of lncRNA regulation in innate and adaptive immune responses, immune cell development, and differential expression of lncRNAs in autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), type 1 diabetes mellitus (T1DM), multiple sclerosis (MS), autoimmune thyroid disease (AITD), psoriasis, polymyositis/dermatomyositis (PM/DM) and Crohn's disease (CD).
Copyright © 2015. Published by Elsevier B.V.
autoimmune disease; autoimmunity; immune function; lncRNA; non-coding RNA
[PubMed - as supplied by publisher]
Even the Wiki article is long and complex!