Regular readers may remember that I've been posting recently about my low-normal fT3 result, coupled with high-normal fT4 and suppressed TSH. Because the fT3 was low in range (3.8 (3.5-5.5)) I decided to purchase some 25mcg Tiromel tablets from Cyprus and start on a combination T3/T4 therapy. Much good advice was given by the community, especially by the ever-wonderful Clutter.
Nine days in and I feel even more wiped out than before. I was previously on 150mcg T4, and was advised to drop to 125mcg T4 and add in 6.25mcg T3 in the morning. I am fairly certain that I need to take a higher dose of T3 but how long should I wait having just started on T3 before adjusting the dosage upwards? I have not noticed any side effects that I could attribute to the T3, only to the higher dose of T4 making its way out of my system (much more tired, cold, slightly crampy muscles). In addition my anxiety and depression are making a comeback and my work life is suffering. I still continue to exercise (running / lots of walking) as it's hardwired in for diabetes-dodging purposes. Can't stop, won't stop. Yeah, I know I should but I won't, so...
If T4 has a half-life of a couple of weeks should I give it until the end of the week and then add in a second dose of T3? In the morning with the first dose, or at another time? I have started to feel like I'm hitting a wall around 11h00 or so, which might indicate that I need to take some more then.
Or is it possible that the T3 I bought is not working for whatever reason? If so, short of taking a bit too much and seeing if there's any reaction, how would I know?
It's all *so* complicated and I just want to be well again. I'm seeing my GP tomorrow and will want to go through this with her so answers appreciated ASAP (well, by the middle of tomorrow morning, at least). I should note that my GP is happy to be guided by me through this whole experiment and will do the monitoring; I'm hoping that if the trial goes well I might be able to persuade her to prescribe T3 on the NHS. I will also ask for a referral to an Endo just to see if they've got anything useful to say. My NHS experience so far has been very good.