Thyroid UK
82,932 members97,976 posts

Thyroid Hormone Resistance _ correlation between B1/mitochondria?

It is likely that I have resistance to thyroid hormone. I am now on 135 mcg T3 as a divided dose and feel no difference at all compared to how I felt taking nothing. I have also been diagnosed with a mitochondrial defect which I feel is secondary to the thyroid hormone resistance. I am wondering if anyone has thoughts on this correlation and if supplementing with high dose B vitamins, especially B1 could be helpful. My thinking is this....if transport of thyroid hormone into the cell is an energy dependent process requiring ATP then would supplementing with B1 and/or other B vitamins needed for energy production help to overcome this resistance? Just a theory... makes sense to me but I cant find any research on this other than a study with Hashi and B1 that seemed to improve fatigue.

6 Replies

I would be careful of B6 - there are many reports of high doses causing issues.

I can't remember if I ever posted this link for you:

This might be of interest:

Thiamine uptake is enhanced by thiamine deficiency, and reduced by thyroid hormone and diabetes.



Thanks Rod I will look at the link. However, if thiamine uptake is reduced by thyroid hormone then wouldnt everyone here and elsewhere on Thyroid hormone run the risk of B1 def?


It is interesting that there have been several suggestions that enhanced thiamine intake could be important in thyroid patients. Perhaps this is part of the issue? Perhaps many are suffering at least slightly low thiamine? Mind, the wording of that quoted statement leaves a lot to be desired.


Yes, it is an area that I think deserves further attention. If we look at thyroid hormone resistance or the unremitting fatigue that many experience still on thyroid replacement, this certainly does make some sense in my mind especially when we consider that the B vits are needed for mitochondrial energy production. I also wonder how this may play out with regards to something like Wilson's temperature syndrome which has some of the hallmarks of thyroid hormone resistance. If you consider that many patients with wilsons develop it after a stressful event it makes some sense that there may be some nutritional deficiencies that are also playing a role. B vitamin need goes up with stress and I know that thiamine can be depleted in as little as a few weeks with poor nutrition and increased physiological demand. But the downside of this as I understand is that supplementing can reduce the effectiveness of thyroid hormone. If anyone has any insight please weigh in on this. Am I correct on this assumption that B1 decreases thyroid hormone effectiveness? There was also another study with fibro patients showing good results so from a mitochondrial perspective this makes alot of sense to me


I've often developed food cravings when hypo. I avoid supplements after a previous bad experience but if hypo I can often be seen eating canned tuna fish, and drinking orange juice.


Thank you. My T3 is in capsule form as it is compounded. Should I open them up?


You may also like...