Peripheral thyroid hormone resistance

[dodge1979]

So my endo has said I have something called

Peripheral thyroid hormone resistance

Can anyone tell me what that is

Thanks in advance

[SeasideSusie Remembering]

Did your endo not explain or did you not ask for an explanation?

A TUK search brings up a few previous posts:

healthunlocked.com/thyroidu...

A Google search brings up:

google.co.uk/search?sxsrf=A...

Anyone with personal experience will reply I'm sure but I'd edit the title of your post to include the specific words to attract the attention of those who know about it.

How to edit a post:

support.healthunlocked.com/...

I have deleted your duplicate post.

[Aurealis]

I can’t give you any references or links, only my interpretation of what I’ve read. I understand that the term means that although your blood tests may be in range your body cells are unable to recognise or use the thyroid hormone. So you may need your blood test results high in order to feel well.

Sometimes this situation is explained in terms of reverse T3 - a version of T3 which is the mirror image of normal T3 but is unusable to the body but blocks receptors so making normal T3 ineffective / inaccessible to body cells. Reverse T3 is said to be produced during conversion of T4 to T3. So treatment with Liothyronine instead of levothyroxine removes the need for any conversion and in time the reverse T3 will leave the receptors and things operate more normally.

I think there are also competing arguments that deficiencies in some minerals can impede transfer of thyroid hormone to cells / impede conversion and this is another possible interpretation of thyroid hormone resistance.

A cynic like me might add - those individuals whose set point lies above the average range

[dodge1979 in reply to Aurealis]

Thanks you for this.

I am feeling good

Except my tiredness in the afternoons

My last T3 was 7.2. High over range

Endo can’t get my TSH under 1.1

I need to be under 0.1

He has me on 125 T4 and 20 T3 at the moment daily

[Aurealis in reply to dodge1979]

Are you taking your T3 in split doses. You may be able to reduce the tiredness by redistributing the T3, for instance reducing the dose before the tiredness and increasing the dose after the tiredness

[SlowDragon Administrator in reply to dodge1979]

Many people find it better to split T3 into 2 of 3 small doses

10mcg waking. 5mcg mid afternoon and 5mcg early evening or at bedtime

It's easy to cut T3 with sharp craft scalpel

Others find taking T3 once a day work well

Recommended on here that all thyroid blood tests should ideally be done as early as possible in morning and before eating or drinking anything other than water . This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip, best not mentioned to GP or phlebotomist)

Last Levothyroxine dose should be 24 hours prior to test, (taking delayed dose immediately after blood draw).

If/when also on T3, make sure to take last 5mcg dose 8-12 hours prior to test, even if this means adjusting time or splitting of dose day before test

Is this how you do your tests?