Recently changed Dr within my surgery and thought I had made it, He wrote to hospital Endo to explain my issue, We had spoken about when thyroxine dropped by 25mcg I became lethargic low and all that was offered was anti-depressants.But when on my 150mcg I function well. I spoke about my 6 sessions at the gym each week that kept me fit yet never did any weight loss happen. Here is the Endo's response. I am unsure what the GP had put in his letter, obviously he had given previous blood results.
I had a TT in 1999. Had anti depressants on and off for years. Currently off. Fed Up and angry with letter. At 13 stone and being 5ft 4 I am hardly using it in using it for weight loss as is written here.
The thyroid function test that have performed since Dec 2003 all show that she is chronically over replaced with thyroxine.There is a period of time between Jan 2002 and Aug 2003 wher her thyroid function test are within range but between jan 200 and Nov 2001 she is again showing results that indicate over replacement. It is perfectly possible to feel tired and exhausted because you are chronically thyrotoxic and using thyroxine as a method of weight loss is not medically recommended. Having TSH that is permanently suppressed below 0.1mU/L and often completely suppressed below the level of assay detection puts her at risk of developing AF which as you know itself carries a risk of stroke. There is no advantage in putting her on T3 replacement, she just needs to get used to her lower thyroxine replacement dose. Having been over replaced for the past 10 years she is going to find it very difficult to make that reduction,