Thyroid UK


Has anybody tried taking this to help with high corisol levels and subsequent weight gain particularly around the middle.

I have been reading about its use and am quite can be bought on Amazon. Im always cautious about things that reduce weight gain, promote weight loss etc (Im on T3 and I still cant lose the weight along with intermittent fasting 2 times a week and taking Orlistat). Most of my weight seems to be around my middle which is a cortisol issue.

From reading about this supplement I also understand why doctors who know about thyroid things, try to suggest you shouldnt do much exercise until you're at the optimal dose because apparently exercise raises your cortisol levels!

So, Im thinking of trying this out because it also helps with potential dementia, alzheimers and ordinary menopausal memory loss, dementia. More importantly Id love to think that the high cortisol levels are what are causing me to hold on to the weight.

Do we think it might interact with T3 or T4 etc etc?

I welcome your thoughts.

5 Replies

Phosphatidylserine (PS) and phosphatidylcholine (PC) are both phospholipids which can be purchased online. The only experience I have had with them is that my daughter was given intravenous PC as part of her treatment in California this year to aid the removal of toxins from her body. I would be very wary of advising anyone to take it unless under the guidance of a trained practitioner. It had a very dramatic effect on my daughter. Her body was very toxic and had great difficulty coping with the speed at which the PC dealt with the toxins. Fortunately she was in a clinic when the PC was administered so she was very carefully monitored. I would seek medical advice before taking it or PS. Jane x


I'm also very interested in this but have more reading to do.

For some reason I've reacted badly with Isocort this time. Last year it really helped me with T3.

Like you, my weight is around the middle and it is so upsetting. But there's definitely something else going on in my body and high cortisol sounds a possibility.

Do you have any interesting links please? (just being a bit lazy here!!). Obviously do keep us updated whichever route you go down.


This came up when I was digging on the topic. It's clearly a marketing page, and not neutral - but it makes lots of claims:

I've been posting on my experience with phosphorylated serine to help get my blood pressure under control - which this ad knocks and vice versa. The BP seems to be cused by high cortisol. The phosphorylated version is reputedly a more easily used form than the phosphatidyl serine according to the makers data sheet.

Here's a version of the story arguing for the phosphorylated type:

Both seem to be fairly widely used in the US by naturopathic doctors, and for quite some time, and there's lots of fairly casual reports about from users - some on quite high doses, and for some years. The makers data sheet primarily describes the chemistry of the product, but doesn't make a lot by way of medical claims for it.

That said I couldn't dig up solid information beyond that on dosage, risks, long term effects or anything like that - and so can't offer any assurance whatsoever beyond that and the data sheet that's about.

I eased into it carefully and gradually. It has produced a very significant improvement in my blood pressure situation and wellbeing (gut function, calmness, energy levels, sleep and so on) as some of you already know from my posts in the two months i've been taking it - and i'm aware of no side effects. It's been relatively easy on the stomach - much more so than for example blood pressure medication.

I've posted some info links before on using serines to manage cortisol. This is another page by a seemingly highly qualified doctor which describes a similar approach, as well as a broader dietary strategy. Who knows, but she seems to regard it as pretty routine:

I'd be dead interested to hear of anybody has more/better information to add to the mix...



I have ordered some PS from Amazon and am excited to see what difference it makes in all sectors of typical cortisol problems. I will keep you informed.


I found to useful to take Seriphos (Phosphorylated Serine - related but usually cheaper) in the evening when I had high nighttime cortisol. Definitely made me sleep. Now I just have low normal cortisol all the time, so it stopped working. I didn't put on fat round the middle, so I can't comment on that.

Isocort never did anything for me.


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