Some time ago when I was searching for information on hypothyroidism I found The National Academy of Hypothyroidism nahypothyroidism.org a non-profit, multi disciplinary medical society, dedicated to the dissemination of new information on the diagnosis and treatment of hypothyroidism.
ALL DOCUMENTS ON THE SITE ARE PROTECTED BY COPYRIGHT.
In the section on Deiodinases you can read about:
Understanding Local Control of Thyroid Hormones (Deiodinases Function and Activity),
Deiodinase type I (D1) Deiodinase type II (D2) Deiodinase type III (D3) Stress, Depression, Pain, Dieting, Leptin, Exercise , Iron deficiency, Inflammation associated with common conditions, Environmental Toxins, Testosterone, Growth hormone, and. Individual variations in deiodinase which includes the Summary.
The Pain section--- I found that pain specialists recommend T3 supplementation to patients with significant pain or on narcotic pain medications.
The Leptin section--- states that in an elevated leptin level (above 10) there is a reduction of cellular T3 and a suppression of TSH, which makes the TSH an unreliable indicator of thyroid status. Also, anyone who has difficulty losing weight, a leptin level above 10 demonstrates that low intracellular thyroid levels is contributing to this difficulty.
Thyroid Hormone Transport
Diagnosis of hypothyroidism: Are we getting what we want from TSH testing?
Why Doesn’t My Endocrinologist Know All of This?
There is such an abundance of information available here which is backed up with references, that it could/should, give GPs and endocrinologists food for thought.
The only problem with all this information is, how on earth do we get our GPs and Endocrinologists to accept these findings?
If anyone has any ideas on how to break through the great wall of bigotry, which surrounds main stream endocrinology, especially in relation to hypothyroidism, please, do let us know.
Quite frankly, I really am weary of trying.