Hi. I'm 55 and have had IBS since at least the age of 17 but not diagnosed till almost 30. Symptoms have become so frequent recently that I am on mebeverine permanently. I have recently had two bad experiences after taking senna tablets, even one. I also have ME and take Citalopram for a pre-existing anxiety/depression condition and a low dose of progesterone for post-menopausal symptoms. Grateful for any advice on things which have helped you.