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Xtandi
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Not sure how to interpret results of new tests
Adding
Xtandi
after last bump in PSA seems OK. Onc. Dr. satisfied with blood results. LDH was only one out of bounds at 239 units/L Still waiting for PSA--lab said equipment problem and sent sample to Phoenix lab. 5to7 day turnaround.
Adding
Xtandi
after last bump in PSA seems OK. Onc. Dr. satisfied with blood results. LDH was only one out of bounds at 239 units/L Still waiting for PSA--lab said equipment problem and sent sample to Phoenix lab. 5to7 day turnaround.
Shooter1
in
Advanced Prostate Cancer
6 years ago
Xtandi and Zytiga Given Together
From the Full Prescribing Information for
- Drug Interactions: Avoid
CYP3A4
, CYP2C9 and CYP2C19 substrates with a narrow therapeutic index, as
XTANDI
may decrease the plasma exposures of these drugs.
From the Full Prescribing Information for
- Drug Interactions: Avoid
CYP3A4
, CYP2C9 and CYP2C19 substrates with a narrow therapeutic index, as
XTANDI
may decrease the plasma exposures of these drugs.
RLSharp
in
Advanced Prostate Cancer
6 years ago
Am I on track ???
Had a RRP July 2016 at UCLA along with a clinical trial which included some hardcore drugs.
xtandi
was one of them. No margins, but seminal V , and some lymph nodes positive.
Had a RRP July 2016 at UCLA along with a clinical trial which included some hardcore drugs.
xtandi
was one of them. No margins, but seminal V , and some lymph nodes positive.
G9doingfine
in
Advanced Prostate Cancer
6 years ago
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Ralaniten [EPI-506]
drug ... which binds to a unique region in the N-terminus domain of both the full-length and the truncated constitutively active splice variants of the AR, {&} is currently in clinical trials for patients who previously received abiraterone, enzalutamide, or both." i.e. could be useful with Zytiga/
Xtandi
drug ... which binds to a unique region in the N-terminus domain of both the full-length and the truncated constitutively active splice variants of the AR, {&} is currently in clinical trials for patients who previously received abiraterone, enzalutamide, or both." i.e. could be useful with Zytiga/
Xtandi
pjoshea13
in
Advanced Prostate Cancer
6 years ago
Thank you for allowing me to be a silent participant
He went through Toxetire (please pardon my spelling), Lupron,
xtandi
, and zytega. The last scan in December showed a significant tumor in his liver and the plan was to biopsy the tumor to see if he now had liver cancer or if it had originated from the prostate cancer.
He went through Toxetire (please pardon my spelling), Lupron,
xtandi
, and zytega. The last scan in December showed a significant tumor in his liver and the plan was to biopsy the tumor to see if he now had liver cancer or if it had originated from the prostate cancer.
Mydadhascancer
in
Advanced Prostate Cancer
6 years ago
I'm Struggling
I have recently added
Xtandi
to the mix. The scary development has been progression in bony mets. I met with my radiation oncologist yesterday and he said that although I don't have any new mets, he's concerned about two sites in my spine. I have mets at T6,T7 and L4.
I have recently added
Xtandi
to the mix. The scary development has been progression in bony mets. I met with my radiation oncologist yesterday and he said that although I don't have any new mets, he's concerned about two sites in my spine. I have mets at T6,T7 and L4.
paulofaus
in
Advanced Prostate Cancer
6 years ago
Xtandi side affects
Cancer in my lymph nodes ,bones and a spot on the back bone, 6 rounds of chemo ,lupron every month , have been on
Xtandi
now for 13 months. Problems. Bone pain ,weakness,loss of manhood.
Cancer in my lymph nodes ,bones and a spot on the back bone, 6 rounds of chemo ,lupron every month , have been on
Xtandi
now for 13 months. Problems. Bone pain ,weakness,loss of manhood.
larry_dammit
in
Advanced Prostate Cancer
6 years ago
Diagnosis of NEPC- Low PSA High Chromogranin A
He failed
Xtandi
(3mo absolutely no changes) and now was recommended to start Jevtana and carboplatin. He has so far had chemo #1. As I was doing some research Today I recall Dr.Kwan explaining that it does not have the “small cell pattern” but definitely looks like Neuroendocrine involvement.
He failed
Xtandi
(3mo absolutely no changes) and now was recommended to start Jevtana and carboplatin. He has so far had chemo #1. As I was doing some research Today I recall Dr.Kwan explaining that it does not have the “small cell pattern” but definitely looks like Neuroendocrine involvement.
Daddysdaughter
in
Advanced Prostate Cancer
6 years ago
Treatment change imminent for mcrpc
Now the docs must decide what to do next and it looks like
Xtandi
or Keytruda (immunotherapy) off study. Neither is likely to be as effective as the Zytiga. The other option is to look at clinical trials of which there are many in the large metro area I live in. I meet with my medonc next week.
Now the docs must decide what to do next and it looks like
Xtandi
or Keytruda (immunotherapy) off study. Neither is likely to be as effective as the Zytiga. The other option is to look at clinical trials of which there are many in the large metro area I live in. I meet with my medonc next week.
cholly75
in
Advanced Prostate Cancer
6 years ago
I am implementing my pH 7.2-7.5 Protocol (My Hypothesis) on myself Since I accidentally stumbled on Green Tea high pH 8.0 to 9.0
On the 24 December 17 after chatting with Dan59 and finding Neal has Zytiga & Prednisone failing (Did not know that Dan59 has problems too and had to add
Xtandi
as additional) I decided to give Vernon Johnstone baking soda/honey ( replaced molasses) a try from 24-30 December 17.
On the 24 December 17 after chatting with Dan59 and finding Neal has Zytiga & Prednisone failing (Did not know that Dan59 has problems too and had to add
Xtandi
as additional) I decided to give Vernon Johnstone baking soda/honey ( replaced molasses) a try from 24-30 December 17.
Roland632017
in
Advanced Prostate Cancer
6 years ago
Apalutamide - SPARTAN versus Enzalutamide - PROSPER.
Apalutamide (previously known as ARN-509) is an androgen receptor [AR] antagonist similar to Enzalutamide [
Xtandi
], except that it has "greater potency and several-fold reduced central nervous system permeation" [1].
Apalutamide (previously known as ARN-509) is an androgen receptor [AR] antagonist similar to Enzalutamide [
Xtandi
], except that it has "greater potency and several-fold reduced central nervous system permeation" [1].
pjoshea13
in
Advanced Prostate Cancer
6 years ago
I wonder if I am the only cancer guy with this exhaustion
I know many of you say you are tired....I now started on
Xtandi
..just 1 to start , but once again (I sound like a recording..saying this over and over...but I know this exhaustion is not normal...ever since my Provenge trtmt.
I know many of you say you are tired....I now started on
Xtandi
..just 1 to start , but once again (I sound like a recording..saying this over and over...but I know this exhaustion is not normal...ever since my Provenge trtmt.
sidnw
in
Advanced Prostate Cancer
6 years ago
Don’t know where I go from here.
I have been through: Lupron continuous from beginning, Strive, Docetaxal,
Xtandi
, Radium 223, Cabazitaxel, Mitoxantrone and other radiation treatments for pain etc. You can go back and look at my prior post for better timeline.
I have been through: Lupron continuous from beginning, Strive, Docetaxal,
Xtandi
, Radium 223, Cabazitaxel, Mitoxantrone and other radiation treatments for pain etc. You can go back and look at my prior post for better timeline.
Glsn10
in
Advanced Prostate Cancer
6 years ago
Radium 223 (Xofigo)
So I’ve been taking
Xtandi
and having a very difficult time. Today my oncologist said to stop it as she could see how it was affecting me. Starting me on Radrum 223 (Xofigo). Don’t see anything on this here when I do a search......any words of wisdom?
So I’ve been taking
Xtandi
and having a very difficult time. Today my oncologist said to stop it as she could see how it was affecting me. Starting me on Radrum 223 (Xofigo). Don’t see anything on this here when I do a search......any words of wisdom?
Jashelby
in
Advanced Prostate Cancer
6 years ago
Castration resistant prostate cancer
Thus far, I have had 39 radiation treatments, have been on Lupron for over one year (in tandem with Bicumulide first, and now
Xtandi
). Due to a recent increase in my PSA, I will soon begin Provenge treatment.
Thus far, I have had 39 radiation treatments, have been on Lupron for over one year (in tandem with Bicumulide first, and now
Xtandi
). Due to a recent increase in my PSA, I will soon begin Provenge treatment.
N-Kitch
in
Advanced Prostate Cancer
6 years ago
Xtandi and Increasing PSA
My father has Been on
Xtandi
, since September 20 2017. (3.5mo) his PSA is going up and his last reading was today 14. Sept 4.1, 6.44 and now 14!! I guess it’s not working and his cancer is not responding to it. Anyone else have this happen? What did your oncologist do?
My father has Been on
Xtandi
, since September 20 2017. (3.5mo) his PSA is going up and his last reading was today 14. Sept 4.1, 6.44 and now 14!! I guess it’s not working and his cancer is not responding to it. Anyone else have this happen? What did your oncologist do?
Daddysdaughter
in
Advanced Prostate Cancer
6 years ago
thoughts from a newby
First line hormone therapy (ADT) injection degarelix Firmagon, another ADT docetaxel Taxotere, chemotherapy now given alongside ADT abiraterone Zytiga enzalutamide Extandi,
Xtandi
Prednisone or Prednisolone, corticosteroid (type of steroid) to treat/avoid allergies Ra 223 dichoride Xofigo
First line hormone therapy (ADT) injection degarelix Firmagon, another ADT docetaxel Taxotere, chemotherapy now given alongside ADT abiraterone Zytiga enzalutamide Extandi,
Xtandi
Prednisone or Prednisolone, corticosteroid (type of steroid) to treat/avoid allergies Ra 223 dichoride Xofigo
rpol
in
Advanced Prostate Cancer
6 years ago
Olaparib/Durvalumab Combo Shows Promise in mCRPC
“But emerging data suggest potential activity in combinations, as seen with results reported with enzalutamide (
Xtandi
) plus pembrolizumab (Keytruda) and with a DNA-based vaccine plus pembrolizumab.”
“But emerging data suggest potential activity in combinations, as seen with results reported with enzalutamide (
Xtandi
) plus pembrolizumab (Keytruda) and with a DNA-based vaccine plus pembrolizumab.”
JLS1
in
Advanced Prostate Cancer
6 years ago
Anyone with similar experience?
Then treated with taxotere with prednisone and xgeva injections then treated with cabazitaxel and finally
xtandi
while still getting xgeva injections monthly. The
xtandi
seemed to be working well - brought his PSA down to .80 but suddenly he had difficulty walking.
Then treated with taxotere with prednisone and xgeva injections then treated with cabazitaxel and finally
xtandi
while still getting xgeva injections monthly. The
xtandi
seemed to be working well - brought his PSA down to .80 but suddenly he had difficulty walking.
GTWaites
in
Advanced Prostate Cancer
6 years ago
Going wrong way after only 6 months
Now trying to get insurance to allow addition of
xtandi
to my mix. Hoping for the best...I have grand kids who need to learn a lot from me. Doug
Now trying to get insurance to allow addition of
xtandi
to my mix. Hoping for the best...I have grand kids who need to learn a lot from me. Doug
Shooter1
in
Advanced Prostate Cancer
6 years ago
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