My father was diagnosed with mCRPC 6 months later after continuing ADT. Was found to have Neuroendocrine PCA per Dr. Kwon at Mayo. His reaction when looking at his scans when comparing them With previous scans were obvious that the PC had spread to more lymph nodes and existing ones have become much larger. He failed Xtandi (3mo absolutely no changes) and now was recommended to start Jevtana and carboplatin. He has so far had chemo #1. As I was doing some research Today I recall Dr.Kwan explaining that it does not have the “small cell pattern” but definitely looks like Neuroendocrine involvement. Everything I have read so far doesn’t seem to look promising even with chemo. I’m asking this community if anyone has had NEPC not small cell and has success with chemo. If not, what other treatments have you had access or trials to?