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In rare flop, Merck calls it quits on Keytruda-Lynparza combo in prostate cancer
Compared with either Johnson & Johnson’s Zytiga or Astellas and Pfizer’s
Xtandi
, the Keytruda-Lynparza combo failed to further extend patients’ lives, nor did it stall tumor progression. All patients had prior chemo treatment and one of the two hormone therapies.
Compared with either Johnson & Johnson’s Zytiga or Astellas and Pfizer’s
Xtandi
, the Keytruda-Lynparza combo failed to further extend patients’ lives, nor did it stall tumor progression. All patients had prior chemo treatment and one of the two hormone therapies.
fmenninger
in
Advanced Prostate Cancer
2 years ago
Chemo
Do any of you think that maybe
Xtandi
could work? Could Darolutamide also be a possibility or is this drug only used with no Mets? He has to wait a couple more months for any trial due to blood clots. Could really use some feedback. Thank you
Do any of you think that maybe
Xtandi
could work? Could Darolutamide also be a possibility or is this drug only used with no Mets? He has to wait a couple more months for any trial due to blood clots. Could really use some feedback. Thank you
Fight11
in
Advanced Prostate Cancer
2 years ago
Zytiga vs Xtandi
One oncologist likes Zytiga over
Xtandi
and the other one likes
Xtandi
over Zytiga. I do have HBP, currently well controlled avg 117/74 and diabetes 2, recently dropped A1C from 8.4 to 6.6 with diet & exercise + metformin 500 twice a day. History of arrhythmia/AFib with mother and uncle.
One oncologist likes Zytiga over
Xtandi
and the other one likes
Xtandi
over Zytiga. I do have HBP, currently well controlled avg 117/74 and diabetes 2, recently dropped A1C from 8.4 to 6.6 with diet & exercise + metformin 500 twice a day. History of arrhythmia/AFib with mother and uncle.
TnRebel62
in
Advanced Prostate Cancer
2 years ago
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What’s next
Was on
Xtandi
but the SE were terrible my wife diagnosed with pancreatic cancer and she is being treated at Vanderbilt 4 hours away. I could not drive that far while on the drug. Also had several falls. Just looking for help on what’s next
Was on
Xtandi
but the SE were terrible my wife diagnosed with pancreatic cancer and she is being treated at Vanderbilt 4 hours away. I could not drive that far while on the drug. Also had several falls. Just looking for help on what’s next
Bobcat64
in
Advanced Prostate Cancer
2 years ago
Overwhelmed with mucus
Sometime during
Xtandi
and Zytiga use I noticed a large amount if phlegm buildup in my windpipe. It has progressed to the point of coughing a lot to loosen and spit it out. Sleep has been affected. This has progressed over a two year period. Has anyone had a similar problem?
Sometime during
Xtandi
and Zytiga use I noticed a large amount if phlegm buildup in my windpipe. It has progressed to the point of coughing a lot to loosen and spit it out. Sleep has been affected. This has progressed over a two year period. Has anyone had a similar problem?
docbulldog
in
Advanced Prostate Cancer
2 years ago
Here we go again….
He added Zytiga in 2019 (PSA had gone back to 11) Recommendation now to re-do taxotere series (x 10 vs past x 6 doses), then add
xtandi
as follow-up….continuing lupron, Zytiga, too. Going to do some blood testing for genetic markers, etc.
He added Zytiga in 2019 (PSA had gone back to 11) Recommendation now to re-do taxotere series (x 10 vs past x 6 doses), then add
xtandi
as follow-up….continuing lupron, Zytiga, too. Going to do some blood testing for genetic markers, etc.
Cateydid
in
Advanced Prostate Cancer
2 years ago
Brca1 and metastatic prostate cancer
Zytiga and
xtandi
both stopped responding , he has been on olaparib for 6 months . Recent scan showed progression AND rise is psa. What should be next step . Local dr says chemo , but was hoping for clinical trailsTHANKS FOR ANY ADVICE
Zytiga and
xtandi
both stopped responding , he has been on olaparib for 6 months . Recent scan showed progression AND rise is psa. What should be next step . Local dr says chemo , but was hoping for clinical trailsTHANKS FOR ANY ADVICE
danyelpolo
in
Advanced Prostate Cancer
2 years ago
Does anyone have any xtandi. They said I missed my enrollment, and all the paper work and waiting till onething after the other. So I
Need
xtandi
out have to wait , till all paper work is in the Wright place. They said I could be out for 2 weeks, so far I have had good things to say about
xtandi
, 20 MO, little side effects , I don't know what this 2 weeks will do. God bless all of you.
Need
xtandi
out have to wait , till all paper work is in the Wright place. They said I could be out for 2 weeks, so far I have had good things to say about
xtandi
, 20 MO, little side effects , I don't know what this 2 weeks will do. God bless all of you.
Bossman071645
in
Advanced Prostate Cancer
2 years ago
Biden’s quest to lower drug prices should start with the prostate medication Xtandi
But that's because the Rx Companies want the MO to keep subscribing these meds. https://qz.com/2126025/biden-can-easily-cut-the-price-prostate-cancer-drug-
xtandi
/
But that's because the Rx Companies want the MO to keep subscribing these meds. https://qz.com/2126025/biden-can-easily-cut-the-price-prostate-cancer-drug-
xtandi
/
de-luke
in
Advanced Prostate Cancer
2 years ago
Attempts to reduce cost of Xtandi in the USA
My husbands cost for
Xtandi
is $10,000 a year on Medicare!!! While no where near wealthy our retirement income exceeds that for help from
Xtandi
or any grants. While researching costs of this drug we found out it was developed by UCLA using government funds!
My husbands cost for
Xtandi
is $10,000 a year on Medicare!!! While no where near wealthy our retirement income exceeds that for help from
Xtandi
or any grants. While researching costs of this drug we found out it was developed by UCLA using government funds!
OTPrincess
in
Advanced Prostate Cancer
2 years ago
Benefit of "triplet therapy" confirmed with enzalutamide too
volume metastases. https://www.urotoday.com/conference-highlights/asco-2022/asco-2022-prostate-cancer/137646-asco-2022-updated-overall-survival-outcomes-in-enzamet-anzup-1304-an-international-cooperative-group-trial-of-enzalutamide-in-metastatic-hormone-sensitive-prostate-cancer-mhspc.html Enzalutamide (
Xtandi
volume metastases. https://www.urotoday.com/conference-highlights/asco-2022/asco-2022-prostate-cancer/137646-asco-2022-updated-overall-survival-outcomes-in-enzamet-anzup-1304-an-international-cooperative-group-trial-of-enzalutamide-in-metastatic-hormone-sensitive-prostate-cancer-mhspc.html Enzalutamide (
Xtandi
Tall_Allen
in
Advanced Prostate Cancer
2 years ago
Chasing rivals, Bayer files Nubeqa for new prostate cancer
Part of that will be to include patients with metastatic, hormone-sensitive prostate cancer (mHSPC) on the label, a group with more advanced disease that is already treated with blockbuster oral androgen receptor inhibitors like Pfizer/Astellas
Xtandi
(enzalutamide) and J&J’s Erleada (apalutamide).
Part of that will be to include patients with metastatic, hormone-sensitive prostate cancer (mHSPC) on the label, a group with more advanced disease that is already treated with blockbuster oral androgen receptor inhibitors like Pfizer/Astellas
Xtandi
(enzalutamide) and J&J’s Erleada (apalutamide).
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Is anyone on ADT taking collagen for joint pain and bone health?
I am stage four on Eldergaurd (Lupron) and
Xtandi
, a met in the hips and one in the spine. I am taking several supplements including calcium and D3. Should I be taking collagen?
I am stage four on Eldergaurd (Lupron) and
Xtandi
, a met in the hips and one in the spine. I am taking several supplements including calcium and D3. Should I be taking collagen?
de-luke
in
Advanced Prostate Cancer
2 years ago
Update, diagnosed 12/26/2018
Tried
Xtandi
and it didn’t work. Had new Mets C7/T3. Painful. Had it zapped and is better. Also had lesion left trochanter zapped. Could hardly move my leg. Worked wonders. Had gene testing and was CHK 2. Tried lynparza and it was bad. No help.
Tried
Xtandi
and it didn’t work. Had new Mets C7/T3. Painful. Had it zapped and is better. Also had lesion left trochanter zapped. Could hardly move my leg. Worked wonders. Had gene testing and was CHK 2. Tried lynparza and it was bad. No help.
Altamonttt
in
Advanced Prostate Cancer
2 years ago
PSA stable / oxybutinin side effects
My question is should he start Zytiga or
Xtandi
to lower his PSA more? He is still using the cather and lately has developed bladder spasms and was described oxybutinin but after a few days he developed low blood. He is already on lisinopril and amlodipone also on short term urobel.
My question is should he start Zytiga or
Xtandi
to lower his PSA more? He is still using the cather and lately has developed bladder spasms and was described oxybutinin but after a few days he developed low blood. He is already on lisinopril and amlodipone also on short term urobel.
naples2021
in
Advanced Prostate Cancer
2 years ago
The 5 Year Club
Immediately was put on casodex for 2 weeks, 6 rounds of chemo, completed provenge and currently on
Xtandi
for 24 months now. PSA is undetectable.
Immediately was put on casodex for 2 weeks, 6 rounds of chemo, completed provenge and currently on
Xtandi
for 24 months now. PSA is undetectable.
Nicnatno
in
Advanced Prostate Cancer
2 years ago
Prostate pain - xtandi/Xofigo & spot radiation
He is currently on
Xtandi
, had high dose spot radiation last Friday to a large new met on his rib. Finished radium 223 in December full 6 infusions.
He is currently on
Xtandi
, had high dose spot radiation last Friday to a large new met on his rib. Finished radium 223 in December full 6 infusions.
Nickhmcg
in
Advanced Prostate Cancer
2 years ago
Dad to start Xtandi, does it work in later treatment times?
Any experience with
Xtandi
being used later in treatment?
Any experience with
Xtandi
being used later in treatment?
Radtech40
in
Prostate Cancer Network
2 years ago
Admitted to hospital, low hemoglobin
Currently taking
xtandi
, finsihed Xofigo end of December, decapeptyl every 3 months, lots of pain meds oxy Contin / amatrypaline/Mirtaxapine /melatonin / stilnoct Thank you in advance 🍀
Currently taking
xtandi
, finsihed Xofigo end of December, decapeptyl every 3 months, lots of pain meds oxy Contin / amatrypaline/Mirtaxapine /melatonin / stilnoct Thank you in advance 🍀
Nickhmcg
in
Advanced Prostate Cancer
2 years ago
Status on Xtandi effect
Hi Folks, you may remember I was speculating that the
Xtandi
dosage was designed in the clinical trials to be at the max possible without incurring adverse side effects. There was little attention paid to the efficacy of the doses.
Hi Folks, you may remember I was speculating that the
Xtandi
dosage was designed in the clinical trials to be at the max possible without incurring adverse side effects. There was little attention paid to the efficacy of the doses.
Stoneartist
in
Advanced Prostate Cancer
2 years ago
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