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Most Inflammatory Disease Patients on Immunosuppressants Mount a Response to the COVID-19 Vaccine (But Can Vary a Lot by Medication)
People taking JAK inhibitor medications (which include Xeljanz, Olumiant, and Rinvoq) also had a modest reduction in antibody levels — a 4.5-fold decrease compared to healthy controls.
Should You Get the COVID-19 Vaccine During a Disease Flare-Up?
Your doctor should provide guidance for your unique situation (and may advise against any medication changes based on your disease status, such as if you’re having a flare), but these medications include:
Methotrexate
JAK inhibitors (ex: Xeljanz, Olumiant, Rinvoq)
Abatacept (Orencia), injectable or
7 Questions to Ask Your Rheumatologist If You’re Nervous About Getting the COVID-19 Vaccine
These medications include:
Methotrexate
JAK inhibitors (ex: Xeljanz, Olumiant, Rinvoq)
Abatacept (Orencia), injectable or IV form
Rituximab (Rituxan)
Cyclophosphamide infusion
Even if your doctor decides you should not taper off any of these medications, it’s still worth it to get the vaccine.
Getting a COVID-19 Vaccine with Autoimmune or Inflammatory Rheumatic Disease: New Guidance from the American College of Rheumatology
JAK inhibitors (ex: Xeljanz, Olumiant, Rinvoq): Skip for 1 week after each vaccine dose
The guidance recommends that patients stop taking these medications, which are oral pills taken daily, for one week after each COVID-19 vaccine dose.
ACR: Vaccinate patients with musculoskeletal, inflammatory, autoimmune disease for COVID-19
.), tofacitinib (Xeljanz, Pfizer) and upadacitinib (Rinvoq, AbbVie) — and some biologics — abatacept (Orencia, Bristol Myers Squibb) and rituximab (Rituxan, Genentech) — that alter the immune system’s response in ways that might affect vaccine response.
What to Know About Getting the Second COVID-19 Vaccine Dose If You’re Immunocompromised or Have an Autoimmune Condition
The American College of Rheumatology recently recommended that some patients can stop taking methotrexate and JAK inhibitors [such as tofacitinib (Xeljanz), baricitinib (Olumiant), and upadacitinib (Rinvoq)] for one week after each vaccine dose.