Tyrosine Hydroxylase Inhibitors and Dopam... - Cure Parkinson's

Cure Parkinson's

26,568 members27,876 posts

Tyrosine Hydroxylase Inhibitors and Dopamine Receptor Agonists Combination Therapy for Parkinson’s Disease

JayPwP profile image
3 Replies

Anyone seen this? This is what JSBMD is talking about

pmc.ncbi.nlm.nih.gov/articl...

Conclusions

TH inhibitors down-regulate DA levels and protect DA neurons, while DA receptor agonists function to activate post-synaptic DA receptors to alleviate PD symptoms. NAC and anticholinergic drugs may be added to improve therapeutic effects. A multi-drug combination therapy including TH inhibitors should be further explored in clinical trials in PD patients.

Written by
JayPwP profile image
JayPwP
To view profiles and participate in discussions please or .
Read more about...
3 Replies
CaseyInsights profile image
CaseyInsights

Anyone seen this? This is what JSBMD is talking about.

Maybe. Here is a link to α-Methyltryptamine a TH inhibitor.

en.wikipedia.org/wiki/Α-Met...

Theoretically viable. But here is the kicker -

A multi-drug combination therapy including TH inhibitors should be further explored in clinical trials in PD patients. 🌺

JayPwP profile image
JayPwP in reply toCaseyInsights

Hey!

Long time no see...

CaseyInsights profile image
CaseyInsights in reply toJayPwP

…indeed. Battling some Parkinson’s demons though some deep dives into research literature.

Hang in there ✨👍🏾✨

Not what you're looking for?

You may also like...

Electroconvulsive Therapy Intervention for Parkinson’s Disease

Have not heard of this option before: Electroconvulsive Therapy Intervention for Parkinson’s...

ALZFORUM article: Genetic Findings Link Parkinson’s Disease to Crohn’s Disease, and to Inflammation

"... LRRK2 inhibitors being developed for PD might help people with Crohn’s disease, while...
jeffreyn profile image

Parkinson’s disease and iron

While the initial causes of Parkinson’s disease (PD) are not clearly defined, iron deposition has...
Farooqji profile image

Impaired finger dexterity and nigrostriatal dopamine loss in Parkinson’s disease

Impaired finger dexterity occurs in Parkinson’s disease (PD) at an early stage and disturbs many...
Farooqji profile image

Fecal microbiota transplantation (FMT) therapy for Parkinson’s disease - A preliminary study in China

"The objective of this study was to assess the efficacy and safety of FMT on PD. Fifteen PD...
jeffreyn profile image