Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson's Disease

[Bolt_Upright]

A mouse study, and just an abstract, but it is pro-curcumin and so am I so I am sharing it:

Integrating Network Pharmacology, Transcriptomics to Reveal Neuroprotective of Curcumin Activate PI3K / AKT Pathway in Parkinson's Disease 2024 pubmed.ncbi.nlm.nih.gov/390...

Background: Parkinson's disease (PD) is the most prevalent movement disorder. Curcumin, a polyphenol with hydrophobic properties, has been proved against Parkinson. Our previous study suggested that curcumin's effectiveness in treating Parkinson's disease may be linked to the gut-brain axis, although the specific mechanism by which curcumin exerts neuroprotective effects in the brain remains unknown.

Methods: The therapeutic efficacy of curcumin was evaluated using behavioral tests, immunofluorescence of tyrosine hydroxylase (TH). Network pharmacology and transcriptomics predicted the mechanisms of curcumin in PD. Activation of the phosphatidylinositol 3-kinase PI3K/AKT pathway was confirmed by quantitative polymerase chain reaction (qPCR) and immunofluorescence.

Results: Curcumin restored the dyskinesia and dopaminergic neurons damage of MPTP-induced mice. Curcumin against Parkinson's disease by regulating inflammation, oxidative stress, and aging. The mechanisms of these were associated with activation of PI3K / AKT pathway.

Conclusion: In conclusion, the neuroprotective mechanisms of curcumin activate PI3K / AKT pathway in Parkinson's disease was revealed by our study.

[Bolt_Upright]

This is my old detailed post on why I use Curcumin: Curcumin Update 2023/03/06 - healthunlocked.com/cure-par...

[reedboat2]

I recall the extract you were using. How many mg are you taking per day?

[Bolt_Upright in reply to reedboat2]

One gram in the morning, and one gram at night. Lots of good detail in that old post I linked to. Good to hear from you.

[reedboat2]

Got it, thanks. Good post, and great to hear from you as well - JG

[JayPwP]

Thank you Bolt...

[TracyLaine]

Thanks Bolt! Do you know of any other studies using the 2g daily of Meriva? I’ve been looking for the daily recommendations and I’m only finding 1 g a day (500 mg twice a day, which is what I am taking). I’m just concerned about the long-term safety of 2 g per day. Thanks!

[Bolt_Upright in reply to TracyLaine]

The only study using 2 grams a day is the one in my other post: The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study academic.oup.com/jnen/artic...

It's a good question. I don't know if 2 grams a day is safe. That is what I take. I liked that this study actually improved the skin biopsy test. That seems big to my high school educated brain: "shows a tendency to decrease misfolded α-syn deposits in skin nerves as supported by the multiple regression model." "In agreement with the main effect of curcumin on autonomic symptoms, we found that patients treated with curcumin tend to have a reduction in p-syn load in skin nerves at the time of follow-up, compared to untreated patients showing increased skin aggregates."