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Transurethral resection of the prostate (TURP)
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Relugolix/Orgovyx or Enzalutamide/Xtandi?
Good morning, all. I have updated my profile with my husband's history. But, long story short, he has been on ADT vacation for 13 months following succesful treatment of metastatic disease with Triplet Therapy (six rounds of Docetaxel, Lupron, and first Abieraterone plus Prednisone and then he switched
Good morning, all. I have updated my profile with my husband's history. But, long story short, he has been on ADT vacation for 13 months following succesful treatment of metastatic disease with Triplet Therapy (six rounds of Docetaxel, Lupron, and first Abieraterone plus Prednisone and then he switched
FaithOverFear104
in
Advanced Prostate Cancer
4 months ago
Failing ADT
Hi- I thought I would seek some advice before I meet with my MO tomorrow morning. I have responded well to treatment of metPC since my dx 11+ years ago. About 2+ years ago my PSA became measurable and was rising. After about a year or so I think it reached .37. Following a PSMA scan, my MO saw only
Hi- I thought I would seek some advice before I meet with my MO tomorrow morning. I have responded well to treatment of metPC since my dx 11+ years ago. About 2+ years ago my PSA became measurable and was rising. After about a year or so I think it reached .37. Following a PSMA scan, my MO saw only
jfoesq
in
Advanced Prostate Cancer
6 months ago
Positive induction stories?
Hi, I’m due to be induced tomorrow, I’m 39+2 (I have gestational diabetes which is why I’m being induced) but I’m terrified, I’ve read/ heard all horror stories on induction not working, taking too long and still ending up with c-section. Has anyone had a positive induction experience that can help ease
Hi, I’m due to be induced tomorrow, I’m 39+2 (I have gestational diabetes which is why I’m being induced) but I’m terrified, I’ve read/ heard all horror stories on induction not working, taking too long and still ending up with c-section. Has anyone had a positive induction experience that can help ease
AJR30
in
Pregnancy and Parenting Support
10 months ago
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Metastatic Prostate Cancer Market to Exhibit Positive Growth at a CAGR of 22%
Good to see such a significant investment in the Prostate Cancer Therapy Market. https://www.prnewswire.com/news-releases/metastatic-prostate-cancer-market-to-exhibit-positive-growth-at-a-cagr-of-22-and-7-5-for-mhspc-and-mcrpc-respectively-during-the-study-period-20192032-assesses-delveinsight-302013725
Good to see such a significant investment in the Prostate Cancer Therapy Market. https://www.prnewswire.com/news-releases/metastatic-prostate-cancer-market-to-exhibit-positive-growth-at-a-cagr-of-22-and-7-5-for-mhspc-and-mcrpc-respectively-during-the-study-period-20192032-assesses-delveinsight-302013725
rfgaus
in
Advanced Prostate Cancer
7 months ago
PSA to have stabilized after skyrocketing. What does this mean?
With PSA rising very rapidly four months ago after finishing Eclipse Trial, I had SBRT done immediately followed by Provenge. PSA on the day of SBRT was 2.0. It’s my understanding that Provenge will not affect PSA testing so it’s hard to determine progress. Obviously, there is still cancer still there
With PSA rising very rapidly four months ago after finishing Eclipse Trial, I had SBRT done immediately followed by Provenge. PSA on the day of SBRT was 2.0. It’s my understanding that Provenge will not affect PSA testing so it’s hard to determine progress. Obviously, there is still cancer still there
SViking
in
Advanced Prostate Cancer
6 months ago
mHSPCa with undetectable PSA - chemo-only?
Is chemo-only justified, without ADT/androgen receptor pathway inhibitors, in a case like mine with two new mets discovered and with PSA less than 0.1? I have had no SOC medication since 2.5 years, after SRBR to a single identified met. Gleason 9. This study points to ADT not being of benefit to low-PSA
Is chemo-only justified, without ADT/androgen receptor pathway inhibitors, in a case like mine with two new mets discovered and with PSA less than 0.1? I have had no SOC medication since 2.5 years, after SRBR to a single identified met. Gleason 9. This study points to ADT not being of benefit to low-PSA
Purple-Bike
in
Advanced Prostate Cancer
6 months ago
4 years post EBRT (44) PSA 0.1 Up from undetectable.
MO thinks it will go up hopefully slowly. Recheck psa in 3 months. Dumb question maybe. Stage 4?
MO thinks it will go up hopefully slowly. Recheck psa in 3 months. Dumb question maybe. Stage 4?
Chasu
in
Advanced Prostate Cancer
4 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Advanced Prostate Cancer
5 months ago
Should the dose of Dutasteride be increased?
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
The plot above shows the residual (nadir) level of DHT in men as a function of the daily Dutasteride dose (mg/day). The DHT nadir numbers shown in this plot are: 23.8 pg/mL for 0.5 mg daily dose; 10.2 pg/mL for 2.5 mg daily dose; and 7.3 pg/mL for 5 mg daily dose. Ref: Clark (2004) [see Table
janebob99
in
Prostate Cancer Network
5 months ago
Low PSA + high Gleason-FYI
I’ve just heard that this is a thing. Unfortunately it seems to affect my outcome. For instance, I had an initial PSA of 4.8 (4.6 after retesting), and I’m Gleason 9. Three of my doctors have mentioned it to me in passing (most recently today), which led me to Google it. https://www.ncbi.nlm.nih.gov
I’ve just heard that this is a thing. Unfortunately it seems to affect my outcome. For instance, I had an initial PSA of 4.8 (4.6 after retesting), and I’m Gleason 9. Three of my doctors have mentioned it to me in passing (most recently today), which led me to Google it. https://www.ncbi.nlm.nih.gov
Jpburns
in
Advanced Prostate Cancer
6 months ago
It's Back!
This post should be good for newbies also. This should show you guys how long you can go!Anyways, 13 years ago I was diagnosed with PCA Gleason 7 PSA 44. With spread outside of prostate. Did 39 treatments off radiation and have been mostly on ADT for the duration except during COVID I took a break
This post should be good for newbies also. This should show you guys how long you can go!Anyways, 13 years ago I was diagnosed with PCA Gleason 7 PSA 44. With spread outside of prostate. Did 39 treatments off radiation and have been mostly on ADT for the duration except during COVID I took a break
Tjc1
in
Advanced Prostate Cancer
6 months ago
Low testosterone is associated with extremely poor survival metrics, post-ADT.
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
These companion plots compare: (A) median survival times, (B) PSA doubling times, and (C) Time to PSA Failure for two different levels of testosterone: Low and Normal. The low testosterone has a median value of 162 ng/dL [120-236] and the average normal T = 680 ng/dL. The cohort is 58 men with unfavorable
janebob99
in
Prostate Cancer Network
5 months ago
My own PSA values over time: 70% drop in just 3 months on Dutasteride and no ADT
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
Here are my own PSA values versus time plot. You can see there is an exponential rise in PSA starting at around 6/1/23, and doubling from PSA = 5 to 10 in about 8 months. My MRI at PSA = 10 showed a T3a tumor about 1.3 cm long (PIRADS 5). A subsequent targeted biopsy showed Gleason 3+4 in 4 cores,
janebob99
in
Prostate Cancer Network
5 months ago
Doubling Times and PSA acceleration - Part II
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
This is a more realistic schematic plot of PSA levels increasing over time at an ever faster rate (acceleration). What could cause this? My theory is that as the tumor grows, the number of androgen receptors (ARs) increases proportionally. That makes sense...more PCa cells inside a tumor...more ARs
janebob99
in
Prostate Cancer Network
5 months ago
PSA levels will increase over time, depending on the level of testosterone - Part I
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
Here's a schematic plot of the increase in PSA level (or increase in tumor volume) over time, for various levels of testosterone (while the tumor is relatively small). At very low levels of testosterone (for example, T = 10 ng/dL), the increase in PSA level is very small after a given time (for example
janebob99
in
Prostate Cancer Network
5 months ago
Baseline PSMA-Pet scan?
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
My MO has given me instructions to end treatment 7/31. I've been on Lupron & Zytiga/5mg prednisone since 8/1/2022. I started out with Gleason (3+4) 7. Last May I had pelvic radiation to hit lymph nodes as per a 2021 PSMA-Pet scan. Now it's time to stop all treatment at the 2 year mark. My MO just kind
duxlubber
in
Advanced Prostate Cancer
5 months ago
stopping Abiratrerone
I was diagnosed with PC in Jan 2001 with Gleason of 4+ and a PSA that never got above 10. From a PSMA scan, I have bone metasteses in skull, ribs, backbone, hips, pelvic bone. WE believe that in my case PSA has never been a very useful measure. I have been taking Abiraterone, Prostap and prednisolone
I was diagnosed with PC in Jan 2001 with Gleason of 4+ and a PSA that never got above 10. From a PSMA scan, I have bone metasteses in skull, ribs, backbone, hips, pelvic bone. WE believe that in my case PSA has never been a very useful measure. I have been taking Abiraterone, Prostap and prednisolone
Stephen399b
in
Advanced Prostate Cancer
3 months ago
Interesting study on combination of statins and metformin in high-risk patient outcomes
https://www.academia.edu/99363002/Individual_and_joint_effects_of_metformin_and_statins_on_mortality_among_patients_with_high_risk_prostate_cancer?email_work_card=view-paper Interesting paper - basically showing that statins reduce PCa mortality among high-risk PCa patients, metformin doesn't appear
https://www.academia.edu/99363002/Individual_and_joint_effects_of_metformin_and_statins_on_mortality_among_patients_with_high_risk_prostate_cancer?email_work_card=view-paper Interesting paper - basically showing that statins reduce PCa mortality among high-risk PCa patients, metformin doesn't appear
Don_1213
in
Advanced Prostate Cancer
5 months ago
NX 1607 - phase 1 trial, will also recruit prostate cancer patients but not from the beginning
Also some prostate cancer patients will be included in the trial further down the road...let's just keep this in mind https://www.cancernetwork.com/view/trial-will-assess-nx-1607-safety-and-tolerability-in-advanced-malignancies
Also some prostate cancer patients will be included in the trial further down the road...let's just keep this in mind https://www.cancernetwork.com/view/trial-will-assess-nx-1607-safety-and-tolerability-in-advanced-malignancies
Maxone73
in
Advanced Prostate Cancer
7 months ago
Immunotherapy could surprise us: Columbia study about mCRPC patients
"Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the disease starts to spread." https://www.cuimc.columbia.edu/news/metastatic-prostate-cancer-immunotherapy-may-have-unexpected-potential
"Immunotherapy has been disappointing as a prostate cancer treatment, but a new Columbia study suggests that the powerful treatments have potential when the disease starts to spread." https://www.cuimc.columbia.edu/news/metastatic-prostate-cancer-immunotherapy-may-have-unexpected-potential
Maxone73
in
Advanced Prostate Cancer
7 months ago
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