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REFINING MY PREVIOUS QUESTION (,,, food for thought): should it be preferable in PSP to take phenylalanine instead of tyrosin supplements?
REFINING MY QUESTION (,,, food for thought...) Tyrosine is a dopamine percursor and as such appears to be a good option for supplementation in PSP. “Tyrosine hydroxylase” is the enzyme responsible for catalyzing the conversion of the amino acid L- tyrosine to L-DOPA. Tyrosine can also be made of phenylalanine
REFINING MY QUESTION (,,, food for thought...) Tyrosine is a dopamine percursor and as such appears to be a good option for supplementation in PSP. “Tyrosine hydroxylase” is the enzyme responsible for catalyzing the conversion of the amino acid L- tyrosine to L-DOPA. Tyrosine can also be made of phenylalanine
BluesHealer
in
PSP Association
3 years ago
Tirosint 50 microgrammi/1 ml a day
Hi everyone, I was diagnosed in 2018 with Hypothyroid Hashimoto and have been taking 50 microgrammi a day. Last week I did my blood test and my TSH is high 5.56. I will have to go to my endocrinologist and see what she will do. I feel very anxious and jittery. Is this normal?
Hi everyone, I was diagnosed in 2018 with Hypothyroid Hashimoto and have been taking 50 microgrammi a day. Last week I did my blood test and my TSH is high 5.56. I will have to go to my endocrinologist and see what she will do. I feel very anxious and jittery. Is this normal?
Hamster18
in
Thyroid UK
3 years ago
Back to Melatonin - Dosing?
I won't go as deep as Art does on Melatonin, but am picking up on a point Art makes often: Dosing! I read all these papers and frankly skim over a lot. Today somebody on FB reposted one of my favorites: 2021 - Melatonin as a Chronobiotic and Cytoprotective Agent in Parkinson’s Disease https://www.ncbi.nlm.nih.gov
I won't go as deep as Art does on Melatonin, but am picking up on a point Art makes often: Dosing! I read all these papers and frankly skim over a lot. Today somebody on FB reposted one of my favorites: 2021 - Melatonin as a Chronobiotic and Cytoprotective Agent in Parkinson’s Disease https://www.ncbi.nlm.nih.gov
Bolt_Upright
in
Cure Parkinson's
3 years ago
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Enzalutamide versus Abiraterone Acetate/Prednisone
New French study below [1]. It is well-known that there is overlap in the reasons why resistance to Enzalutamide [Xtandi] & Abiraterone [Zytiga] occur. This means that many will see little added benefit from the two drugs taken sequentially. So which drug to opt for if given the choice? Abiraterone
New French study below [1]. It is well-known that there is overlap in the reasons why resistance to Enzalutamide [Xtandi] & Abiraterone [Zytiga] occur. This means that many will see little added benefit from the two drugs taken sequentially. So which drug to opt for if given the choice? Abiraterone
pjoshea13
in
Advanced Prostate Cancer
3 years ago
Recently Diagnosed
Hi! I found this forum while searching for information on PD. I have been reading for a few months but never posted. Forgive me, this will be long. I am a 60 year old female in the US, recently diagnosed a few months ago. I was initially hesitant to try medication but recently changed my mind to improve
Hi! I found this forum while searching for information on PD. I have been reading for a few months but never posted. Forgive me, this will be long. I am a 60 year old female in the US, recently diagnosed a few months ago. I was initially hesitant to try medication but recently changed my mind to improve
MomoP
in
Cure Parkinson's
3 years ago
BTK inhibitors for the treatment of CLL - the current state of play of 'brutinibs'
In just a short time, in many places, BTK inhibitors (BTKi) have largely replaced chemoimmunotherapy (CIT) for treatment naive CLL patients, while also playing an important role in relapsed/refractory CLL. For a
detailed list of the many BTK inhibitors
in the pipeline, check out @AussieNeil’s
In just a short time, in many places, BTK inhibitors (BTKi) have largely replaced chemoimmunotherapy (CIT) for treatment naive CLL patients, while also playing an important role in relapsed/refractory CLL. For a
detailed list of the many BTK inhibitors
in the pipeline, check out @AussieNeil’s
CLLerinOz
Volunteer
in
CLL Support
3 years ago
5-HTP + L-TYROSINE for Depression?
Hey guys, I want to know if anyone has experience supplementing with 5-HTP and L-Tyrosine together. I've learned that since 5htp decreases other catecholamines (dopamine, noradrenaline, and adrenaline) we should also be increasing them. But how to maintain proper balance and know the side effects for
Hey guys, I want to know if anyone has experience supplementing with 5-HTP and L-Tyrosine together. I've learned that since 5htp decreases other catecholamines (dopamine, noradrenaline, and adrenaline) we should also be increasing them. But how to maintain proper balance and know the side effects for
xavier65
in
Anxiety and Depression Support
3 years ago
Dark Chocolate for Anxiety, Focus and Attention
Hey all, recently I came across some researchs on dark chocolate. Seems like it has powerful compounds and really does affect our brain. So I bought a dark chocolate bar with 83% cocoa content. It has both negative and positive effects on me. Here's how I feel whenever I eat some: Negative effects (Occur
Hey all, recently I came across some researchs on dark chocolate. Seems like it has powerful compounds and really does affect our brain. So I bought a dark chocolate bar with 83% cocoa content. It has both negative and positive effects on me. Here's how I feel whenever I eat some: Negative effects (Occur
xavier65
in
Anxiety and Depression Support
3 years ago
Daughter still poorly
Her T4 and T3 also increased 🤷🏻♀️ I requested we try
Tirosint
but GOSH suggesting we change to a liquid version of Levothyroxine and dose at 40? Discussed T3/NDT etc previously with all involved but GOSH saying no.
Her T4 and T3 also increased 🤷🏻♀️ I requested we try
Tirosint
but GOSH suggesting we change to a liquid version of Levothyroxine and dose at 40? Discussed T3/NDT etc previously with all involved but GOSH saying no.
Dolphin40
in
Thyroid UK
3 years ago
Supplements to help with DAWS
Has anyone had success with supplements to help repair dopamine damage from DAWS? These are supplements I found from research. Not entirely sure which are most appropriate. Dopa Maxx: https://www.integrativepsychiatry.net/shop/ip-formulas/dopa-maxx-dopamine-supplement/ L-Theanine: https://www.amazon.com
Has anyone had success with supplements to help repair dopamine damage from DAWS? These are supplements I found from research. Not entirely sure which are most appropriate. Dopa Maxx: https://www.integrativepsychiatry.net/shop/ip-formulas/dopa-maxx-dopamine-supplement/ L-Theanine: https://www.amazon.com
Discopage
in
Restless Legs Syndrome
3 years ago
Scientists discover novel oncogenic driver gene in human lung cancer
A research team led by Prof. WANG Yuexiang from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences discovered a novel oncogenic driver gene in human lung cancer, the leading cause of cancer-related mortality worldwide. Their findings were published in Journal
A research team led by Prof. WANG Yuexiang from the Shanghai Institute of Nutrition and Health (SINH) of the Chinese Academy of Sciences discovered a novel oncogenic driver gene in human lung cancer, the leading cause of cancer-related mortality worldwide. Their findings were published in Journal
2greys
in
Lung Conditions Community Forum
3 years ago
Pancreas- It's Role in Human Digestive system every diabetes should know & Top Healthy Foods for a Healthy Pancreas.
Please read the entire post to get the right Perspective. Have a look at the Image of our wonderfully looking Pancreas and it's location in human body in the attached image above. When we talk of Pancreas, we quickly relate it with production of Insulin. But you would be surprised to note that
Please read the entire post to get the right Perspective. Have a look at the Image of our wonderfully looking Pancreas and it's location in human body in the attached image above. When we talk of Pancreas, we quickly relate it with production of Insulin. But you would be surprised to note that
namaha
Administrator
in
Diabetes India
3 years ago
Need to stay strong - some hope ? (too early though)
FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson
FYI - Inhibikase Therapeutics (IKT) is taking a stab at PD. https://finance.yahoo.com/news/inhibikase-initiates-early-stage-study-174801680.html Vandana Singh February 17, 2021 Inhibikase Therapeutics Inc (NASDAQ: IKT) has dosed the first patients in its Phase 1 trial of IkT-148009, an Abelson
John_morris71
in
Cure Parkinson's
3 years ago
Androgen receptor (AR) heterogeneity ... and therapy resistance
New paper below [1]. Back in 2004, PubMed had the findings of a few studies that looked at PCa androgen receptor [AR] at diagnosis & in hormone refractory prostate cancer (HRPC), as CRPC was then called. At diagnosis - meaning before treatment - the AR was essentially 'wild type'. From a
1995[/
New paper below [1]. Back in 2004, PubMed had the findings of a few studies that looked at PCa androgen receptor [AR] at diagnosis & in hormone refractory prostate cancer (HRPC), as CRPC was then called. At diagnosis - meaning before treatment - the AR was essentially 'wild type'. From a
1995[/
pjoshea13
in
Advanced Prostate Cancer
3 years ago
TSH labs
Two weeks ago my TSH was 1.80 with a steady dose of 50mcg of
tirosint
for six weeks. Started an increase at that time of 13mcg more of
tirosint
, but still felt under medicated. Just had labs done again and it's now 1.10 !
Two weeks ago my TSH was 1.80 with a steady dose of 50mcg of
tirosint
for six weeks. Started an increase at that time of 13mcg more of
tirosint
, but still felt under medicated. Just had labs done again and it's now 1.10 !
abartme
in
Thyroid UK
3 years ago
First results of a head-to-head trial of acalabrutinib versus ibrutinib in previously treated chronic lymphocytic leukemia.
Background: Increased selectivity of the Bruton tyrosine kinase inhibitor (BTKi) acalabrutinib (Aca) vs ibrutinib (Ib) may improve tolerability. We conducted an open-label, randomized, noninferiority, phase 3 trial to compare Aca vs Ib in patients (pts) with chronic lymphocytic leukemia (CLL). Methods
Background: Increased selectivity of the Bruton tyrosine kinase inhibitor (BTKi) acalabrutinib (Aca) vs ibrutinib (Ib) may improve tolerability. We conducted an open-label, randomized, noninferiority, phase 3 trial to compare Aca vs Ib in patients (pts) with chronic lymphocytic leukemia (CLL). Methods
Jm954
Administrator
in
CLL Support
3 years ago
Screening and monitoring of the BTK C481S mutation in a real-world cohort of patients with relapsed/refractory chronic lymphocytic leukaemia
On line abstract report 21 May 2021 The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has revolutionised the therapeutic landscape of chronic lymphocytic leukaemia (CLL). Acquired mutations emerging at position C481 in the BTK tyrosine kinase domain are the predominant genetic alterations associated
On line abstract report 21 May 2021 The Bruton's tyrosine kinase (BTK) inhibitor ibrutinib has revolutionised the therapeutic landscape of chronic lymphocytic leukaemia (CLL). Acquired mutations emerging at position C481 in the BTK tyrosine kinase domain are the predominant genetic alterations associated
Jm954
Administrator
in
CLL Support
3 years ago
Help with Lab Results
I am on 137 mcg
Tirosint
(taken 24 hours before labs) and 20 mcg Cytomel ( 5 mcg taken12 hours before labs). I stopped the B12 a week before the labs. I'm not sure why the lab did not test Ferritin. I think iron labs look low. D is adequate. B12 could go up a bit.
I am on 137 mcg
Tirosint
(taken 24 hours before labs) and 20 mcg Cytomel ( 5 mcg taken12 hours before labs). I stopped the B12 a week before the labs. I'm not sure why the lab did not test Ferritin. I think iron labs look low. D is adequate. B12 could go up a bit.
susanmhall62
in
Thyroid UK
3 years ago
What could be the cause of restless leg syndrome
Recently added the following to my husband’s routine and he seemed to be more alert but this morning saw his left leg shaking intermittently 1. Coffee cherry 200 mg increased to 2x a day Suppose to increase BDNF by 141% 2. Ubiquinol 200 mg increased to 3x a day 3. Tryptophan 1000 mg at bed time
Recently added the following to my husband’s routine and he seemed to be more alert but this morning saw his left leg shaking intermittently 1. Coffee cherry 200 mg increased to 2x a day Suppose to increase BDNF by 141% 2. Ubiquinol 200 mg increased to 3x a day 3. Tryptophan 1000 mg at bed time
Millbrook
in
Cure Parkinson's
3 years ago
Big weight lost but still exhausted. Has anyone else experienced this?
I was on 88 Evthyroxin 4/5 days a week, alternating with 75
Tirosint
. (Though I’ve been advised to up Levo to 100, I’ve tried so often and it knocks me off my feet.) So now I’m on 88 Evthyroxin only. We’ll see. I’m still exhausted and brain-foggy.
I was on 88 Evthyroxin 4/5 days a week, alternating with 75
Tirosint
. (Though I’ve been advised to up Levo to 100, I’ve tried so often and it knocks me off my feet.) So now I’m on 88 Evthyroxin only. We’ll see. I’m still exhausted and brain-foggy.
Koola
in
Thyroid UK
3 years ago
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