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CRISPR 13 (what? you thought I abandoned CRISPR?): very promising proof of concept - Targeting HOXB13 in mPCa by CRISPR/Cas13d- nanoparticle
And people thought it was undruggable....they have already filed for a patent š² Researchers developed nanoparticles that can deliver a special type of gene therapy directly to cancer cells in the liver. This system uses a CRISPR technology, not to edit DNA, but to block the RNA of the HOXB13 protein
And people thought it was undruggable....they have already filed for a patent š² Researchers developed nanoparticles that can deliver a special type of gene therapy directly to cancer cells in the liver. This system uses a CRISPR technology, not to edit DNA, but to block the RNA of the HOXB13 protein
Maxone73
in
Advanced Prostate Cancer
1 month ago
constipation
years of laxative abuse leaves me with slow bowel going shortly for biofeedback as have no anal function, have to evacuate myself now Iām passing some stool with interference but so bloated and in pain, am I impacted? Starting laxido today, and a stimulant, swore never to laxative use again but scared
years of laxative abuse leaves me with slow bowel going shortly for biofeedback as have no anal function, have to evacuate myself now Iām passing some stool with interference but so bloated and in pain, am I impacted? Starting laxido today, and a stimulant, swore never to laxative use again but scared
Dudders123
in
IBS Network
1 month ago
Thyroid S in UK
Hello everyone. I am a thyroid patient from Armenia, I have no thyroid for the last 6 years. I tried T4 and T4 and T3 combination therapies, but still I feel sick with many symptoms. I would like to try NDT, can you please advise a reliable source to by Thyroid S online in UK? Thank you.
Hello everyone. I am a thyroid patient from Armenia, I have no thyroid for the last 6 years. I tried T4 and T4 and T3 combination therapies, but still I feel sick with many symptoms. I would like to try NDT, can you please advise a reliable source to by Thyroid S online in UK? Thank you.
helloworl
in
Thyroid UK
1 month ago
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Is it a waste?
How do you know when you stop making progress? If i keep going to these group therapy sessions and hanging out with my family, but have my head ducking down, into my phone or look at the ground to avoid social interactions....does it still count as a visit? i mean i'm not as bad as im describing i do
How do you know when you stop making progress? If i keep going to these group therapy sessions and hanging out with my family, but have my head ducking down, into my phone or look at the ground to avoid social interactions....does it still count as a visit? i mean i'm not as bad as im describing i do
EricJones
in
Anxiety and Depression Support
1 month ago
Major depressive disorder
I was with my ex for 36 years before I foiled for a divorce. We remained close . December 2023 was 1 year for our divorce. He had at least 3 affairs that I proved, I believe he had at least 3 or 4 more that I couldnāt prove. He asked me to move in with him February this year, I did because I thought
I was with my ex for 36 years before I foiled for a divorce. We remained close . December 2023 was 1 year for our divorce. He had at least 3 affairs that I proved, I believe he had at least 3 or 4 more that I couldnāt prove. He asked me to move in with him February this year, I did because I thought
raisin44
in
Anxiety and Depression Support
1 month ago
Change in inhalers
I'm currently on sertide and being switched over to symbicort. I'm not sure of the dosage etc as need to discuss further with gp. I'm a little concerned as been on seretide for years. When I get switched it triggers flares and I've already had loads of time of work. I work part time. I also think I'm
I'm currently on sertide and being switched over to symbicort. I'm not sure of the dosage etc as need to discuss further with gp. I'm a little concerned as been on seretide for years. When I get switched it triggers flares and I've already had loads of time of work. I work part time. I also think I'm
spookylou
in
Asthma Community Forum
1 month ago
combination therapy for ADHD
Does anyone have experience using combination therapy of a stimulant plus a non-stimulant? From what I understand, you take the stimulant in the morning and the non-stimulant in the late afternoon or evening. I recently started using Adderall ir. Having a lot of trouble in the evening and at night
Does anyone have experience using combination therapy of a stimulant plus a non-stimulant? From what I understand, you take the stimulant in the morning and the non-stimulant in the late afternoon or evening. I recently started using Adderall ir. Having a lot of trouble in the evening and at night
starsallover
in
CHADD's Adult ADHD Support
1 month ago
Protein discovery could help solve prostate cancer drug resistance Date:January 22, 2024 Source:Washington State University
I found this information while researching my husband's PSA rising issues. Found it interesting and want to share. Click on link to read the entire article https://www.sciencedaily.com/ Protein discovery could help solve prostate cancer drug resistance Date: January 22, 2024 Source: Washington
I found this information while researching my husband's PSA rising issues. Found it interesting and want to share. Click on link to read the entire article https://www.sciencedaily.com/ Protein discovery could help solve prostate cancer drug resistance Date: January 22, 2024 Source: Washington
MsHope
in
Advanced Prostate Cancer
1 month ago
Feeling paranoid
I'm at group therapy and I'm feeling really paranoid right now. More than usual. I'm afraid that someone will notice my paranoia and shame me for it ...thoughts?
I'm at group therapy and I'm feeling really paranoid right now. More than usual. I'm afraid that someone will notice my paranoia and shame me for it ...thoughts?
EricJones
in
Anxiety and Depression Support
1 month ago
Oxygen therapy
I am helping to look after my 88 year old sister at present. She has been prescribed ambulatory oxygen therapy following a diagnosis of pulmonary hypertension, I think related to her Protein S Deficiency. She is frail and even the small oxygen cylinders are heavy and difficult for her to use but oxygen
I am helping to look after my 88 year old sister at present. She has been prescribed ambulatory oxygen therapy following a diagnosis of pulmonary hypertension, I think related to her Protein S Deficiency. She is frail and even the small oxygen cylinders are heavy and difficult for her to use but oxygen
mozart27
in
Lung Conditions Community Forum
1 month ago
No meds no symptoms
I was told a week ago to stop all my medication due to a chest infection and WBC being too low. I've been off my hydroxychloroquine and methotrexate for over a week now and weirdly my joints and swelling has been the best it's been for over 2 years. I feel perplexed has a 2 year flare just finished
I was told a week ago to stop all my medication due to a chest infection and WBC being too low. I've been off my hydroxychloroquine and methotrexate for over a week now and weirdly my joints and swelling has been the best it's been for over 2 years. I feel perplexed has a 2 year flare just finished
Sunshine634
in
LUPUS UK
1 month ago
Home Oxygen Therapy
I don't recall seeing this mentioned on here but was wondering if anyone had experiences of being discharged home with Oxygen after an ICU stay. I'm a month out of hospital (after a total stay of 8 months). I was discharged with a CPAP machine for OSA and prescribed 1l of oxygen at night whilst in the
I don't recall seeing this mentioned on here but was wondering if anyone had experiences of being discharged home with Oxygen after an ICU stay. I'm a month out of hospital (after a total stay of 8 months). I was discharged with a CPAP machine for OSA and prescribed 1l of oxygen at night whilst in the
CCXLI
in
ICUsteps
1 month ago
Biological therapy.
I have been reading through all the posts on biological therapy.I have literally this week just heard that I qualify for Tezspire. The wait time is about 4 weeks. I am wondering who else is having this / had it and how they are getting on . Thank you.
I have been reading through all the posts on biological therapy.I have literally this week just heard that I qualify for Tezspire. The wait time is about 4 weeks. I am wondering who else is having this / had it and how they are getting on . Thank you.
pmrdec112014
in
Asthma Community Forum
1 month ago
Occupational Therapy
Hi everyone, my 11 year old was diagnosed with ADHD six years ago. I am just wondering for those who are having occupational therapy as part of an accommodation - it what ways has it been helpful or if it has been helpful? Just trying to get a sense of how occupational therapy might fit in.
Hi everyone, my 11 year old was diagnosed with ADHD six years ago. I am just wondering for those who are having occupational therapy as part of an accommodation - it what ways has it been helpful or if it has been helpful? Just trying to get a sense of how occupational therapy might fit in.
Uptowngirl12121
in
CHADD's ADHD Parents Together
2 months ago
Update in sustained release T3 and new paper
The recent review of treatment for hypothyroidism recommended further research to look at combination therapy. A group in Iran have done the following trial looking at sustained release combination T4/T3. Fascinatingā¦ā¦ it suggests that daily sustained release capsules can deliver a stable T3 level over
The recent review of treatment for hypothyroidism recommended further research to look at combination therapy. A group in Iran have done the following trial looking at sustained release combination T4/T3. Fascinatingā¦ā¦ it suggests that daily sustained release capsules can deliver a stable T3 level over
Mollyfan
in
Thyroid UK
2 months ago
Photopharmics kickstarts phototherapy trial for Parkinsonās disease
The US Food and Drug Administration (FDA)-approved device targets photoreceptors in the eye responsible for circadian signalling. Research has shown that Parkinsonās disease can damage the retina and impact the circadian system leading to symptoms such as trouble sleeping, cognition, depression, and
The US Food and Drug Administration (FDA)-approved device targets photoreceptors in the eye responsible for circadian signalling. Research has shown that Parkinsonās disease can damage the retina and impact the circadian system leading to symptoms such as trouble sleeping, cognition, depression, and
Farooqji
in
Cure Parkinson's
2 months ago
Caffeic acid phenethyl ester (CAPE) is an ingredient in bee propolis. See below for invitro and mice evidence for inhibition AR-V7 by CAPE
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Graham49
in
Advanced Prostate Cancer
2 months ago
Iām Coco & today Joolsg suggested I post re upcoming NHS Iron Infusion
Hello RLS people Iāve been here for a while reading & learning, getting the impression this is a very well informed serious & supportive community. Youāve helped me understand a lotā¦but am very aware thereās lots more to get my head around, so thanks for being here! now am about to have this IV
Hello RLS people Iāve been here for a while reading & learning, getting the impression this is a very well informed serious & supportive community. Youāve helped me understand a lotā¦but am very aware thereās lots more to get my head around, so thanks for being here! now am about to have this IV
Barnclown
in
Restless Legs Syndrome
2 months ago
Not PCa related, but interesting new delivery techniques:
"It is a responsive therapy strategy towards the various cell states. This intelligent nanomachine with controlled release of anti-cancer drug in specific cancer cell subtypes can reduce the side effect to normal cells and facilitate the targeted therapy, which is promising as a theranostics nanoplatform
"It is a responsive therapy strategy towards the various cell states. This intelligent nanomachine with controlled release of anti-cancer drug in specific cancer cell subtypes can reduce the side effect to normal cells and facilitate the targeted therapy, which is promising as a theranostics nanoplatform
Maxone73
in
Advanced Prostate Cancer
2 months ago
EMG and NCT tests query
after over 2 years of waiting to be referred, i finally have an appt with neurophysology for EMG and NCT tests but they have booked the appt at 8.30 in the morning. thing is that the symptoms of awful burning/frozen sensation which iniatially were only in my right foot (started about 6 years ago at
after over 2 years of waiting to be referred, i finally have an appt with neurophysology for EMG and NCT tests but they have booked the appt at 8.30 in the morning. thing is that the symptoms of awful burning/frozen sensation which iniatially were only in my right foot (started about 6 years ago at
Crochet_fan
in
Neuropathy Support
2 months ago
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