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CAR T-Cell Developments in Lymphoma Dr. Ian Flinn Highlights
In follicular lymphoma, one of the key updates is the RELEVANCE study that compared rituximab (Rituxan) and chemotherapy with rituximab and lenalidomide (Revlimid; R2). This study was a large, international trial.
Efficacy of lenalidomide in relapsed/refractory chronic lymphocytic leukemia patient: a systematic review and meta-analysis
The ORIGIN trial (NCT00910910), which was evaluating Revlimid treatment for a new use as an initial therapy for chronic lymphocytic leukemia (CLL) in patients 65 years and older, showed higher rates of death in patients treated with Revlimid compared to those treated with chlorambucil.' : [/i]https:/
Remind me again, what is thalidomide and how did it cause so much harm? How did it change the clinical trial process?
approved along with the introduction of processes to capture side effects after a drug's approval, dramatically reshaping the Clinical Trial process into what we have today.
2) Thalidomide has successfully been used to treat CLL and only a few years ago the derivative drug Lenalidomide (trade name Revlimid