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EMBARK Study: Enzalutamide +/- ADT
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
Results of the EMBARK study was published this week (10/19/23) in NEJM. It compared high risk BCR PCa treated in 3 groups: Lupron ADT alone. Enzalutamide plus ADT. And Enzalutamide monotherapy. 5 year follow up for metastasis free survival. Results below. Interesting that Enza monotherapy (No ADT) was
MateoBeach
in
Fight Prostate Cancer
6 months ago
Rheumatoid, Peri-Menopause, HRT
I am 54 and have had RA for 34 years. I am at the end stage of perimenopause, and close to transitioning to Menopause. The RA feels worse. My joints are so achy even my muscles hurt at times. Anyone suggestions from experienced ladies. Does HRT help? My current medication list is Humira 40 by weekly
I am 54 and have had RA for 34 years. I am at the end stage of perimenopause, and close to transitioning to Menopause. The RA feels worse. My joints are so achy even my muscles hurt at times. Anyone suggestions from experienced ladies. Does HRT help? My current medication list is Humira 40 by weekly
ragurl
in
NRAS
6 months ago
Would I be on thin ice if I tried adaptive ADT this soon?
After 6 weeks on Lupron and 9 days on abiraterone, my PSA was .1, and my testosterone was <1. This is within the criteria being used to start people on adaptive in this MCSPC Moffitt study with Jingsong Yang - (he says I can just follow the protocol without being in the study)https://pubmed.ncbi.nlm.nih.gov
After 6 weeks on Lupron and 9 days on abiraterone, my PSA was .1, and my testosterone was <1. This is within the criteria being used to start people on adaptive in this MCSPC Moffitt study with Jingsong Yang - (he says I can just follow the protocol without being in the study)https://pubmed.ncbi.nlm.nih.gov
jackwfrench
in
Advanced Prostate Cancer
6 months ago
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Sleep while taking Xtandi and Adt
Hello everyone, I am sure that this has been discussed on here before, I was unable to find any post to answer my question . I am taking Xtandi ( aprox 16 months) Lupron, I had chemo. My latest PSA was less then <0.01. It has been there for over a year now. ( See my profile for my journey.) My
Hello everyone, I am sure that this has been discussed on here before, I was unable to find any post to answer my question . I am taking Xtandi ( aprox 16 months) Lupron, I had chemo. My latest PSA was less then <0.01. It has been there for over a year now. ( See my profile for my journey.) My
JD-guy
in
Advanced Prostate Cancer
6 months ago
HRT & Anxiety
hI am looking for advice am struggling at the moment with side effects from HRT patches, am only on oestrogen as have no womb. Headaches, nausea and more recent anxiety, am only on a low dose and been on for nearly 4weks. I feel am going crazy, every patch change my arms and hands feel really
hI am looking for advice am struggling at the moment with side effects from HRT patches, am only on oestrogen as have no womb. Headaches, nausea and more recent anxiety, am only on a low dose and been on for nearly 4weks. I feel am going crazy, every patch change my arms and hands feel really
Bassem1979
in
Menopause and Perimenopause Support
6 months ago
Thunking of getting an orchiectomy insted od radiation
Has anyone had an orchiectomy and if so how were your side effects and how is your life after the Big O.I'm scheduled to start Full Pelvic Radiation in 6 weeks but fear the long term side effects. I asked if anyone here had FPR and if so what were their side effects and life like since then. Thanks for
Has anyone had an orchiectomy and if so how were your side effects and how is your life after the Big O.I'm scheduled to start Full Pelvic Radiation in 6 weeks but fear the long term side effects. I asked if anyone here had FPR and if so what were their side effects and life like since then. Thanks for
woppaginny
in
Advanced Prostate Cancer
6 months ago
Reporting results from Eclipse Trial
Prior to beginning trial last June I had just gone castrate resistant and PSA was at 3.3. A few weeks after the last of four injections PSA settled in at .25 so there was still something left. However PSA now has quickly shot up to .75 And since I stopped Orgovyx and Zytiga, Testosterone is going up
Prior to beginning trial last June I had just gone castrate resistant and PSA was at 3.3. A few weeks after the last of four injections PSA settled in at .25 so there was still something left. However PSA now has quickly shot up to .75 And since I stopped Orgovyx and Zytiga, Testosterone is going up
SViking
in
Advanced Prostate Cancer
6 months ago
not diagnosed yet but need pain tips
Hi can anyone give me any tips on dealing with pain please? I’m on a years waiting list now with a gyno to check for endo and ando. I may be going on to HRT soon for the peri menopause. I’ve tried different pain killers, exercise, meditation and mint tea. Nothing works. The pain is only 5 days
Hi can anyone give me any tips on dealing with pain please? I’m on a years waiting list now with a gyno to check for endo and ando. I may be going on to HRT soon for the peri menopause. I’ve tried different pain killers, exercise, meditation and mint tea. Nothing works. The pain is only 5 days
Citrusheights79
in
Endometriosis UK
6 months ago
HOrmone Replacement Therepy
I have wondered for a while whether men also lose hormones as they age and whether patches would be beneficial. I am a complete layman, so may be talking rubbish . I read on one post that Parkinsons can give people hot flushes, so this got me thinking. Have there been any studies please?
I have wondered for a while whether men also lose hormones as they age and whether patches would be beneficial. I am a complete layman, so may be talking rubbish . I read on one post that Parkinsons can give people hot flushes, so this got me thinking. Have there been any studies please?
Jo692
in
Cure Parkinson's
7 months ago
1 Year out Radiation treatment
2018, Gleason 9, family history, RP surgery. Not clear margin. PSA undetectable three years, then back knocking at the door, (.17 PSA rise 2022). BCR! PSMA scan clear. 35 IMRT Radiation treatments to surgery prostate bed, 6 months on Lupron. See my wonderful Radiation Onocolgist on Monday, Dr. Hung,
2018, Gleason 9, family history, RP surgery. Not clear margin. PSA undetectable three years, then back knocking at the door, (.17 PSA rise 2022). BCR! PSMA scan clear. 35 IMRT Radiation treatments to surgery prostate bed, 6 months on Lupron. See my wonderful Radiation Onocolgist on Monday, Dr. Hung,
rickyfish56
in
Advanced Prostate Cancer
4 months ago
Post-prostatectomy cancer status + treatment
Where we are in the story so far ... * 46 yo, diagnosed with prostate cancer April 2023 * MRIs were negative, ultimately diagnosed via biopsy * Gleason 3+4, last PSA 6.3, 6 cores with 3+3, 2 cores were 3+4 * PSMA PET Scan prior to surgery was clean * Had RALP procedure on September 26, 3 weeks ago
Where we are in the story so far ... * 46 yo, diagnosed with prostate cancer April 2023 * MRIs were negative, ultimately diagnosed via biopsy * Gleason 3+4, last PSA 6.3, 6 cores with 3+3, 2 cores were 3+4 * PSMA PET Scan prior to surgery was clean * Had RALP procedure on September 26, 3 weeks ago
MakeItRainbows
in
Prostate Cancer Network
7 months ago
Vacation from ADT
I searched but only came up with vacations at two years or so. I had a meeting with my MO today. He is conservative but suggested I could stop the meds. I was complaining of brain fog. He said to stop the Abi for about three weeks to see if there is any improvement and if not, stop Lupron. My story
I searched but only came up with vacations at two years or so. I had a meeting with my MO today. He is conservative but suggested I could stop the meds. I was complaining of brain fog. He said to stop the Abi for about three weeks to see if there is any improvement and if not, stop Lupron. My story
gsun
in
Advanced Prostate Cancer
7 months ago
ADT and bone health
I am 79 in exceptional physical condition. I have been on ADT after radical Prostatectomy for over 14 months and to date aside from the sexual libido loss I have had very little side effects. I have always been a health / exercise buff & continue to exercise everyday to maintain my mental & physical
I am 79 in exceptional physical condition. I have been on ADT after radical Prostatectomy for over 14 months and to date aside from the sexual libido loss I have had very little side effects. I have always been a health / exercise buff & continue to exercise everyday to maintain my mental & physical
Stevegr
in
Advanced Prostate Cancer
7 months ago
Genomic testing
Who benefits from genetic testing and when? Is it mainly when someone becomes castrate resistant and or metastatic that they recommend it? Or is there value in doing it ahead of things while one is castrate sensitive? Had RP and then salvage radiation with 6 months ADT. 1st lab after.. T of 25 and undectable
Who benefits from genetic testing and when? Is it mainly when someone becomes castrate resistant and or metastatic that they recommend it? Or is there value in doing it ahead of things while one is castrate sensitive? Had RP and then salvage radiation with 6 months ADT. 1st lab after.. T of 25 and undectable
runtrails
in
Advanced Prostate Cancer
7 months ago
Questions about progesterone and prostate cancer
My onco continues to resist prescribing low dose E2 to help minimize some of my ADT SEs. Following my last appointment he suggested progesterone as an alternative. - Has anybody here had success with using progesterone while on ADT? - Any reasons to steer clear of progesterone? Thanks
My onco continues to resist prescribing low dose E2 to help minimize some of my ADT SEs. Following my last appointment he suggested progesterone as an alternative. - Has anybody here had success with using progesterone while on ADT? - Any reasons to steer clear of progesterone? Thanks
Carlosbach
in
Advanced Prostate Cancer
7 months ago
Zolodex and HRT
hi there, my diagnosis is very new and I’ve just had my first zolodex injection this afternoon. I was also given HRT patches containing oestrogen which I’ve put on. But I’m confused as the zolodex surely stoped oestrogen production so why have I been put on patches that give it back? Surely it will counteract
hi there, my diagnosis is very new and I’ve just had my first zolodex injection this afternoon. I was also given HRT patches containing oestrogen which I’ve put on. But I’m confused as the zolodex surely stoped oestrogen production so why have I been put on patches that give it back? Surely it will counteract
Chronsandadenomysois
in
Adenomyosis Advice Association
7 months ago
Happy New Year and Update
Update: I took what I hope will be my last Lupron shot which will work until March 5 /24. I will have had 31 months of Lupron with mostly undetectable PSA. I will have had 29 months of Abiraterone at that point. Had IMRT radiation 24 months ago Both my MO and RO are interested in whether they have
Update: I took what I hope will be my last Lupron shot which will work until March 5 /24. I will have had 31 months of Lupron with mostly undetectable PSA. I will have had 29 months of Abiraterone at that point. Had IMRT radiation 24 months ago Both my MO and RO are interested in whether they have
Scout4answers
in
Advanced Prostate Cancer
4 months ago
How to convince your GP a suppressed TSH is ok?
For years I’ve had a suppressed TSH following a trial of T3 probably 5 years ago which didn’t work and I haven’t taken it for around 4 years (need to check my records for exact dates). My GP has always been fine with it, and even the rubbish NHS endo agreed it would take time to recover - or as I know
For years I’ve had a suppressed TSH following a trial of T3 probably 5 years ago which didn’t work and I haven’t taken it for around 4 years (need to check my records for exact dates). My GP has always been fine with it, and even the rubbish NHS endo agreed it would take time to recover - or as I know
CornishChick
in
Thyroid UK
7 months ago
Low cortisol but within normal nhs range
I have had 2 blood cortisol tests at 9am 1st one was 133 nmol/L and the 2nd one was 233 nmol/L . I asked to have a short synacten test to see if my pituitary is failing ( hypopituitarism) , as one of my big symptoms is low motivation, tiredness, hypothyroidism and zero libido for years despite being
I have had 2 blood cortisol tests at 9am 1st one was 133 nmol/L and the 2nd one was 233 nmol/L . I asked to have a short synacten test to see if my pituitary is failing ( hypopituitarism) , as one of my big symptoms is low motivation, tiredness, hypothyroidism and zero libido for years despite being
minus
in
Thyroid UK
7 months ago
CT and Bone Scan 2 weeks after PSMA PET?
Note:
for reference, my dad lives in BC, Canada. I believe the system here is a bit different than the US - we have a urologist who refers us to the RO when needed. Therefore, there is no relationship between the urologist and RO - the RO is part of the cancer institute, but the urologist is not
Note:
for reference, my dad lives in BC, Canada. I believe the system here is a bit different than the US - we have a urologist who refers us to the RO when needed. Therefore, there is no relationship between the urologist and RO - the RO is part of the cancer institute, but the urologist is not
sixmongoos
in
Advanced Prostate Cancer
7 months ago
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