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Revisiting Intermittent Therapy in Metastatic Prostate Cancer
The A-Dream Phase 2 trial is taking a second look at intermittent therapy for mHSPCa. In the study they hope to answer the question 1. Can intermittent therapy (a break from treatment) for high responders (PSA < .2 over 18-24 mos) on ADT+ARPi be more effective than continuous ADT (the current standard
The A-Dream Phase 2 trial is taking a second look at intermittent therapy for mHSPCa. In the study they hope to answer the question 1. Can intermittent therapy (a break from treatment) for high responders (PSA < .2 over 18-24 mos) on ADT+ARPi be more effective than continuous ADT (the current standard
skiingfiend
in
Advanced Prostate Cancer
11 months ago
Thyroid and HRT?
Hi everyone - sorry for the long post!! I was diagnosed as underactive over 15 years ago (autoimmune) and, as consultant originally explained, I needed to increase levothyroxin dose over the years. For the past few years I've managed reasonably well on 175mcg in winter and 150mcg in summer. I started
Hi everyone - sorry for the long post!! I was diagnosed as underactive over 15 years ago (autoimmune) and, as consultant originally explained, I needed to increase levothyroxin dose over the years. For the past few years I've managed reasonably well on 175mcg in winter and 150mcg in summer. I started
Apollo1
in
Thyroid UK
11 months ago
What study says Zytiga 2 yrs , ADT 3 yrs ?
Im off to see my MO today and am getting close to the 2 yr. mark . All is good so far . I just need to know what was the study that suggests ADT for 3yrs and Zytiga + pred. for 2 yrs . I think tall Allen mentioned it . Thanks , SemperFi , JJ
Im off to see my MO today and am getting close to the 2 yr. mark . All is good so far . I just need to know what was the study that suggests ADT for 3yrs and Zytiga + pred. for 2 yrs . I think tall Allen mentioned it . Thanks , SemperFi , JJ
reconjj
in
Advanced Prostate Cancer
11 months ago
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taxotere and PSA
adt stopped 9/22, daralutamide mono therapy until 7/23. Three rounds of docetaxel until 7/17/23. PSA rose from 4.9 to 5.1. PSMA scan showed decline in bone Mets. Tried a bit of fasting. Just switched to cabitaxel due to seeming failure of docetaxel based on PSA rise. Wondering if PSA increase was the
adt stopped 9/22, daralutamide mono therapy until 7/23. Three rounds of docetaxel until 7/17/23. PSA rose from 4.9 to 5.1. PSMA scan showed decline in bone Mets. Tried a bit of fasting. Just switched to cabitaxel due to seeming failure of docetaxel based on PSA rise. Wondering if PSA increase was the
CWT53
in
Advanced Prostate Cancer
11 months ago
Just for fun--Amazon product notice
I have ordered beta-glucans from Amazon 16 times. Now I get this message (it had the order number and Amazon product number--it was not spam): Dear Amazon Customer, We write to notify you of a potential safety concern with a product that you purchased on Amazon.com. YOUR ORDER ID: 114-2282517-4981047
I have ordered beta-glucans from Amazon 16 times. Now I get this message (it had the order number and Amazon product number--it was not spam): Dear Amazon Customer, We write to notify you of a potential safety concern with a product that you purchased on Amazon.com. YOUR ORDER ID: 114-2282517-4981047
cigafred
in
Fight Prostate Cancer
11 months ago
Can you reject GNRH analogues? Consequences? Please help.
Hi there, I'm going in for my second Endo surgery next week, 9cm endometrioma, and the MRI showed a few other lesions. My last surgery was 6 years ago, and they removed a 16m endometrioma. The surgeon called last week in response to some questions I had and made an offhand remark about having a shot
Hi there, I'm going in for my second Endo surgery next week, 9cm endometrioma, and the MRI showed a few other lesions. My last surgery was 6 years ago, and they removed a 16m endometrioma. The surgeon called last week in response to some questions I had and made an offhand remark about having a shot
SeventeenNineteen
in
Endometriosis UK
11 months ago
ovarian cancer symptom?
In February this year I became unwell with raised GGT, weight loss, fever terrible headaches, malaise and random abdominal pain. To rule out ovarian or liver cancer (!?) Dr arranged gastroscopy which found nothing. Four months on omeprazole and watch and wait until end of June. Weight settled, but
In February this year I became unwell with raised GGT, weight loss, fever terrible headaches, malaise and random abdominal pain. To rule out ovarian or liver cancer (!?) Dr arranged gastroscopy which found nothing. Four months on omeprazole and watch and wait until end of June. Weight settled, but
Stills
in
My Ovacome
11 months ago
Edema
Due to ADT, I have swelling of the stomach due to edema, i guess. Anybody have the same problem? Treatent I should go over with my doc? Also a bit of gynomastia. .
Due to ADT, I have swelling of the stomach due to edema, i guess. Anybody have the same problem? Treatent I should go over with my doc? Also a bit of gynomastia. .
gsun
in
Advanced Prostate Cancer
11 months ago
Morphea treatment - PUVA or triamcinolone injections?
hello, looking for a bit of advice as I was diagnosed with Morphea a few months ago. I’m under the care of dermatology department. It affects my whole left arm, part of my rib cage and some of my right arm. The worst area is around my left wrist where the skin is particularly tight around the joint
hello, looking for a bit of advice as I was diagnosed with Morphea a few months ago. I’m under the care of dermatology department. It affects my whole left arm, part of my rib cage and some of my right arm. The worst area is around my left wrist where the skin is particularly tight around the joint
Katie46
in
Scleroderma & Raynaud's UK (SRUK)
8 months ago
Questions about ADT drugs and insurance
Will Medicare cover Lupron injections under part B as it is not self administered (as opposed to pills)? If so how much will they cover (with a supplement plan). Regarding Orgovyx, since it is a pill and not an injection will it be covered under Medicare part D drug coverage? and if so do all of the
Will Medicare cover Lupron injections under part B as it is not self administered (as opposed to pills)? If so how much will they cover (with a supplement plan). Regarding Orgovyx, since it is a pill and not an injection will it be covered under Medicare part D drug coverage? and if so do all of the
SilverSeppi
in
Advanced Prostate Cancer
11 months ago
Hashi's & Menopause/HRT - weight loss help!
Hi all, I have Hashimoto's and have been on levo 75mg with combined HRT (oestrogen patch and progesterone pill) for a few years. Had a total hysterectomy almost 2 years ago, but they left my ovaries, due to extensive endo, adenomyosis and fibroids. But I have literally been stuck in limbo since then
Hi all, I have Hashimoto's and have been on levo 75mg with combined HRT (oestrogen patch and progesterone pill) for a few years. Had a total hysterectomy almost 2 years ago, but they left my ovaries, due to extensive endo, adenomyosis and fibroids. But I have literally been stuck in limbo since then
Partiallythere
in
Thyroid UK
11 months ago
ADT duration
I have locally contained G9 discovered July as PSA in June 2022 rose to 6.9 , 6 months after HIFU In December 2021. Immediately started Bicalutimide 150 3rd August 2022 and planned radiotherapy for end of November 2022 after clear PSMA. For various reasons I was on bicalutimide for longer than
I have locally contained G9 discovered July as PSA in June 2022 rose to 6.9 , 6 months after HIFU In December 2021. Immediately started Bicalutimide 150 3rd August 2022 and planned radiotherapy for end of November 2022 after clear PSMA. For various reasons I was on bicalutimide for longer than
SimMartin
in
Advanced Prostate Cancer
11 months ago
Thinner lining on transfer day
Hello everyone, I’d really appreciate your experiences. I’ve had a FET today on a natural cycle. 7 days ago my lining was 11.4mm and today for the transfer it was 7.2mm. Has anyone else seen a drop off like this? I asked the doctor and she said it could be that the lining has compacted and that above
Hello everyone, I’d really appreciate your experiences. I’ve had a FET today on a natural cycle. 7 days ago my lining was 11.4mm and today for the transfer it was 7.2mm. Has anyone else seen a drop off like this? I asked the doctor and she said it could be that the lining has compacted and that above
Poppygarden
in
Fertility Network UK
11 months ago
Long survivors with ADT + Xtandi (Enzulatamide)
5 years after RPE and RT my PSA is rising again. I am advised to start ADT + Xtandi. Who are longest still on this combination without getting castration resistant?
5 years after RPE and RT my PSA is rising again. I am advised to start ADT + Xtandi. Who are longest still on this combination without getting castration resistant?
ElemanJ
in
Advanced Prostate Cancer
11 months ago
PSMA PET 2 weeks after EBRT
So my MO scheduled a PSMA PET 2 weeks after the end of my EBRT. I didn't argue and did it. Im seeing her tomorrow and will ask why. Maybe she forgot I did radiation?? Ill ask for another in 3 months. Meanwhile, the report shows the lymph node is now mild uptake SUV 2.5 MAX. It was intensely radiotracer
So my MO scheduled a PSMA PET 2 weeks after the end of my EBRT. I didn't argue and did it. Im seeing her tomorrow and will ask why. Maybe she forgot I did radiation?? Ill ask for another in 3 months. Meanwhile, the report shows the lymph node is now mild uptake SUV 2.5 MAX. It was intensely radiotracer
Hidden
in
Advanced Prostate Cancer
11 months ago
your help needed again.
I started pregabalin in May and the first time i took it at 150mg i started with hallucinations but slept well. I haven’t slept well on it since. I have been checking in on this health site and taking your advice. I Have gradually increased dose to 275 but my sleep has got worse and worse. My partner
I started pregabalin in May and the first time i took it at 150mg i started with hallucinations but slept well. I haven’t slept well on it since. I have been checking in on this health site and taking your advice. I Have gradually increased dose to 275 but my sleep has got worse and worse. My partner
Jukebox55
in
Restless Legs Syndrome
11 months ago
Anxiety and treatments
Hi, Looking for some advice. I have had anxiety for most of my life but managed it until the last few years . I’ve had some big family issues arose plus perimenopausal in the last two years. Since these things have occurred my anxiety has become heightened and i’m trying to manage it with diet , supplements
Hi, Looking for some advice. I have had anxiety for most of my life but managed it until the last few years . I’ve had some big family issues arose plus perimenopausal in the last two years. Since these things have occurred my anxiety has become heightened and i’m trying to manage it with diet , supplements
WeeB
in
Thyroid UK
11 months ago
Novel brain penetrant capsids for Parkinson’s disease gene therapy
https://www.youtube.com/watch?v=7f-TBoq0TLo
https://www.youtube.com/watch?v=7f-TBoq0TLo
Hidden
in
Cure Parkinson's
1 year ago
intensive group therapy as outpatient
Any care to share if it was a positive or negative experience? I start Friday. It is victual for 3 hours , 3 days a week, up to 18 in the group. Never done it before. Feeling skeptical, frightened, and want to get something out of it.
Any care to share if it was a positive or negative experience? I start Friday. It is victual for 3 hours , 3 days a week, up to 18 in the group. Never done it before. Feeling skeptical, frightened, and want to get something out of it.
Lightswitch
in
Mental Health Support
1 year ago
HRT and autoimmune thyroiditis
Am about to be prescribed transdermal oestrogen and progesterone tablets. I am 56 y with much crabbines and fatigue. Have also just discovered that I may have Hashimotot's (see my post). How will HRT affect things? Do I not go ahead with it? Thanks.
Am about to be prescribed transdermal oestrogen and progesterone tablets. I am 56 y with much crabbines and fatigue. Have also just discovered that I may have Hashimotot's (see my post). How will HRT affect things? Do I not go ahead with it? Thanks.
CobaltBlueDark
in
Thyroid UK
11 months ago
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