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Invitro study shows Delta Tocotrienol overcomes Docetaxel resistence in PCa
Necroptosis Induced by Delta-Tocotrienol Overcomes Docetaxel Chemoresistance in Prostate Cancer CellsMarina Montagnani Marelli, Giangiacomo Beretta, Roberta Manuela Moretti International Journal of Molecular Sciences 24 (5), 4923, 2023 Prostate cancer (PCa) represents the fifth cause of cancer death
Necroptosis Induced by Delta-Tocotrienol Overcomes Docetaxel Chemoresistance in Prostate Cancer CellsMarina Montagnani Marelli, Giangiacomo Beretta, Roberta Manuela Moretti International Journal of Molecular Sciences 24 (5), 4923, 2023 Prostate cancer (PCa) represents the fifth cause of cancer death
Graham49
in
Fight Prostate Cancer
10 months ago
PSMA PET Scan result - false positive bone lesion?
My fathers PSMA PET scan ( at 0,23 psa) came back! Its been 9 months after surgery and PSA is around 0,18-0,25 and fluctated down at times. Everything was clear but a suspected bone lesion at L3 was found. The dr seem to think its false positive and said its probably nothing. We should just monitore
My fathers PSMA PET scan ( at 0,23 psa) came back! Its been 9 months after surgery and PSA is around 0,18-0,25 and fluctated down at times. Everything was clear but a suspected bone lesion at L3 was found. The dr seem to think its false positive and said its probably nothing. We should just monitore
Daddysgirl83
in
Advanced Prostate Cancer
9 months ago
PSA dropping and % free ratio rising - why?
OK, so as you can see from my Bio, I live in Australia and was due to start my HT this month. However, on Dec 5th, we decided to do another PSA test and surprisingly it had dropped from 8.1 in July to 4.9, so I thought maybe we should get another MRI to see what is going on. I had the MRI only a few
OK, so as you can see from my Bio, I live in Australia and was due to start my HT this month. However, on Dec 5th, we decided to do another PSA test and surprisingly it had dropped from 8.1 in July to 4.9, so I thought maybe we should get another MRI to see what is going on. I had the MRI only a few
Mike58
in
Prostate Cancer Network
6 months ago
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Complementary Therapies - Your Experience?
My standard of care drugs are doing a great job of keeping my PSA down, but it would seem inconsiderate not to look into giving them a bit of help. I'm investigating these "adjunct" therapies with anecdotal or research evidence showing potential action against prostate cancer, and I'm just wondering
My standard of care drugs are doing a great job of keeping my PSA down, but it would seem inconsiderate not to look into giving them a bit of help. I'm investigating these "adjunct" therapies with anecdotal or research evidence showing potential action against prostate cancer, and I'm just wondering
32Percenter
in
Advanced Prostate Cancer
9 months ago
"Two Invitae CHEK2 variants of "unknown consequence""
Hello - My Hopkins MO says this genetics test indicates a weakness (CHEK2 is one of the 4 or 5 PCa related variants) he thinks this could have contributed to my premature, two year BCR after RP, so he will likely prescribe chemo sooner than later though PSA will be the prime indicator. Further he suggested
Hello - My Hopkins MO says this genetics test indicates a weakness (CHEK2 is one of the 4 or 5 PCa related variants) he thinks this could have contributed to my premature, two year BCR after RP, so he will likely prescribe chemo sooner than later though PSA will be the prime indicator. Further he suggested
jackwfrench
in
Advanced Prostate Cancer
6 months ago
PSA testing comparison question
I know that PSA results can vary, particularly if processed by different labs. Knowing this, I do have a question. Quick recap, I completed 20 rounds of radiation at UCLA with Kishan back in April of this year. At the same time, I began 6 months of ADT. Over the past few months, while getting my
I know that PSA results can vary, particularly if processed by different labs. Knowing this, I do have a question. Quick recap, I completed 20 rounds of radiation at UCLA with Kishan back in April of this year. At the same time, I began 6 months of ADT. Over the past few months, while getting my
LongevityAT
in
Advanced Prostate Cancer
9 months ago
Confused by Decipher Test
Hi all, new here. I signed up to finish reading an article and then saw these posts in an email to me. What a great resource for men with prostate cancer. My PSA went up to 4.4 and then had an MRI which showed a two suspicious lesions (PI-RADS 4 and a PI-RAD 3). Had a biopsy 3 weeks ago and it showed
Hi all, new here. I signed up to finish reading an article and then saw these posts in an email to me. What a great resource for men with prostate cancer. My PSA went up to 4.4 and then had an MRI which showed a two suspicious lesions (PI-RADS 4 and a PI-RAD 3). Had a biopsy 3 weeks ago and it showed
drzaius
in
Prostate Cancer Network
9 months ago
Biopsy results in 2 weeks - questions?
I've finally got an appointment to get the results of my prostate biopsy on Monday in 2 weeks time. It's taken quite a while. My PSA was 12 and an MRI scan showed a dodgy area on the front of the prostate. My PI-RADS score was 5. I was then booked for a biopsy which got deferred 3 times. I was told I
I've finally got an appointment to get the results of my prostate biopsy on Monday in 2 weeks time. It's taken quite a while. My PSA was 12 and an MRI scan showed a dodgy area on the front of the prostate. My PI-RADS score was 5. I was then booked for a biopsy which got deferred 3 times. I was told I
MarkS
in
Prostate Cancer Network
9 months ago
Promising, especially for people with LBD mutation: NEJM Evidence publishes results from Phase I/IIa CYPIDES trial with ODM-208
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
"In phase I, 20 out of the total 47 patients had AR LBD mutation. In phase IIa, all 45 patients had AR LBD mutation. A decrease in PSA (prostate-specific antigen) levels of 50% or more occurred in 14/19 (73.7%) patients with AR LBD mutation and 2/23 (8.7%) AR-wild-type patients in phase I, and in 24/
Maxone73
in
Advanced Prostate Cancer
6 months ago
Ketogenic diet for High risk PCA? American Ginseng for fatigue?
Reaching out for feedback regarding adopting a more ketogenic diet for my husband and using an american ginseng supplement for fatigue. Worth while? Husband is Gleason 9, PSA 46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated
Reaching out for feedback regarding adopting a more ketogenic diet for my husband and using an american ginseng supplement for fatigue. Worth while? Husband is Gleason 9, PSA 46.6 when diagnosed, completed 28 Proton treatments, on Orgovyx and started Abiraterone and prednisone recently. Being treated
CancerConcierge
in
Advanced Prostate Cancer
6 months ago
PSMA Scan post Ra223 treatments
No huge win from his recent treatment is discernable. The doctor (RO) says there's no way of knowing if it won him any extra time. However, we can only assume things might have been worse without it. As we walked out the door, he came back to us specifically to tell us how good he looked (unstated..
No huge win from his recent treatment is discernable. The doctor (RO) says there's no way of knowing if it won him any extra time. However, we can only assume things might have been worse without it. As we walked out the door, he came back to us specifically to tell us how good he looked (unstated..
Tinuriel
in
Advanced Prostate Cancer
10 months ago
Confusing news from oncologist
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
Hi all, looking for some insight or direction based off of any experiences or similar ones. My dad started chemo in October with a PSA of 126. After 2 rounds of chemo, his PSA rose to 153, we saw some increase in his bone metastasis as according to the scans (posted about this previously). My dad
StayingSTRNG
in
Advanced Prostate Cancer
6 months ago
timing between Lupron injections
After 17 months on firmagon injections, I switched to the 84 day lupron injection on June 15. How far can the 84 days be safely extended? I am currently scheduled for another injection on September 14, which is 91 days. I hope that is ok, as our scheduling was extended because of vacation conflicts
After 17 months on firmagon injections, I switched to the 84 day lupron injection on June 15. How far can the 84 days be safely extended? I am currently scheduled for another injection on September 14, which is 91 days. I hope that is ok, as our scheduling was extended because of vacation conflicts
Gatodd
in
Advanced Prostate Cancer
10 months ago
Blood in Urine
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Hi fellow fighters Had blood in my urine the last 10 days. Hoped it was a UTI but a course of antibiotics has failed. I had a bladder neck incision last June to help urinary flow. The urologist saw a suspicious patch and a biopsy confirmed it my prostate cancer has spread to my bladder. I’m hoping
Tonyliv
in
Advanced Prostate Cancer
6 months ago
T flare with Lupron jab
Does every Lupron injection leads to a temporary testosterone flare or just the first one?I'm on 3 monthly Lupron jab. I got my first erection in weeks (with Viagra) after my 2nd jab and was wondering if that was because of the Lupron jab a few days earlier.
Does every Lupron injection leads to a temporary testosterone flare or just the first one?I'm on 3 monthly Lupron jab. I got my first erection in weeks (with Viagra) after my 2nd jab and was wondering if that was because of the Lupron jab a few days earlier.
John347
in
Advanced Prostate Cancer
10 months ago
Conflicting MRI vs PSMA scans
Well it appears that the radiologist who did my MRI was overly cautious. The report said I had a met on my left pelvis, one on my right pelvis, one on my sacrum, additional cancer in my prostate region and sclerotic foci in my pelvic region. Traumatic. We followed that up with a PSMA scan 10 days
Well it appears that the radiologist who did my MRI was overly cautious. The report said I had a met on my left pelvis, one on my right pelvis, one on my sacrum, additional cancer in my prostate region and sclerotic foci in my pelvic region. Traumatic. We followed that up with a PSMA scan 10 days
icanwintwice
in
Advanced Prostate Cancer
9 months ago
How do we determine if cancer is in remission
Just had my fourth of five Cyber Knife treatments and my doctor said everything has been going "great." It turns out that means when the treatment was performed my bladder was full and my rectum was empty. When I asked if another Petscan was on the horizon he told me that it was unlikely that my insurer
Just had my fourth of five Cyber Knife treatments and my doctor said everything has been going "great." It turns out that means when the treatment was performed my bladder was full and my rectum was empty. When I asked if another Petscan was on the horizon he told me that it was unlikely that my insurer
GrantB47
in
Advanced Prostate Cancer
6 months ago
PSA Test
Hello everybody Where can I find good information about the readings on PSA tests. As I have posted earlier, my husband had the prostate removed, developed a rezidiv after 5 years, was treated with Proton (based on Hydrogen) radiation in Heidelberg January this year. PSA went down from 0,8 to 0,3.
Hello everybody Where can I find good information about the readings on PSA tests. As I have posted earlier, my husband had the prostate removed, developed a rezidiv after 5 years, was treated with Proton (based on Hydrogen) radiation in Heidelberg January this year. PSA went down from 0,8 to 0,3.
Grommi
in
Advanced Prostate Cancer
9 months ago
Go-forward Treatment Plan
First of all, I've been an avid reader of this forum over the past 2 years, and wanted to express my gratitude towards the amount of knowledge everyone has been sharing on this site. My father (62 y.o., very healthy) was diagnosed with aggressive PCa (Gleason 9, PSA 58) in Sep 2021, and underwent RALP
First of all, I've been an avid reader of this forum over the past 2 years, and wanted to express my gratitude towards the amount of knowledge everyone has been sharing on this site. My father (62 y.o., very healthy) was diagnosed with aggressive PCa (Gleason 9, PSA 58) in Sep 2021, and underwent RALP
sixmongoos
in
Advanced Prostate Cancer
9 months ago
PSA 9 , age 66 , is there an alternative to biopsy ?
My friend’s PSA went from 5 to 9 in 8 months . He asked me if there is an alternative to biopsy . I told him that there may be something new since I last had a biopsy in 2009.
My friend’s PSA went from 5 to 9 in 8 months . He asked me if there is an alternative to biopsy . I told him that there may be something new since I last had a biopsy in 2009.
PBnative
in
Advanced Prostate Cancer
9 months ago
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