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Initial Phase 1 Data on MB-105 for Patients with PSCA-positive Castration Resistant Prostate Cancer
From what I understand PSCA is highly expressed in prostate cancer cells but also in other kinds of cancer and also in other tissues (in small amounts), and its production increases as the disease progresses, making it a better target for later stages (but this is my speculation!). What is important
From what I understand PSCA is highly expressed in prostate cancer cells but also in other kinds of cancer and also in other tissues (in small amounts), and its production increases as the disease progresses, making it a better target for later stages (but this is my speculation!). What is important
Maxone73
in
Advanced Prostate Cancer
4 months ago
Cortisol result help in interpreting please
Hi Hashimoto's sufferer for 40 years and ill most of that time. Worsening symptoms although I have had these symptoms before just not as long lasting or debilitating as they have been over the last 12 months. Treated with Levothyroxine only (this after being advised in writing by an endocrinologist 6
Hi Hashimoto's sufferer for 40 years and ill most of that time. Worsening symptoms although I have had these symptoms before just not as long lasting or debilitating as they have been over the last 12 months. Treated with Levothyroxine only (this after being advised in writing by an endocrinologist 6
Shebbie
in
Thyroid UK
4 months ago
Ketogenic diet alters the epigenetic and immune landscape of prostate cancer to overcome resistance to immune checkpoint blockade therapy.
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
Overall, this strikes me as too hypothetical for us to apply, but what do I know? "Overall, these findings illuminate a potential clinical path of using HDACi and optimized KD regimens to enhance ICB therapy for PCa." HDACi = histone deacetylase inhibitor [To date, four HDAC inhibitors, Vorinostat
cigafred
in
Fight Prostate Cancer
4 months ago
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If PSA is Suppressed by Doublet ADT, Will Salvage IMRT Cause a PSA Rise?
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
Hello everyone, My husband is nearing completion of his extended pelvic salvage IMRT with boost to retrocaval lymph nodes. His radiation oncologist said it may take several months before the psa calms down, so he would like to see him in July. My question is that, since he is already undetectable due
103532
in
Advanced Prostate Cancer
4 months ago
HDR Brachytherapy after initial RT
Anyone has a success story to share on using HDR Brachytherapy 2-3 years after initial Radiation of the prostate gland in case of recurrence of cancer? Thank you for sharing your story.
Anyone has a success story to share on using HDR Brachytherapy 2-3 years after initial Radiation of the prostate gland in case of recurrence of cancer? Thank you for sharing your story.
Simonapo
in
Advanced Prostate Cancer
4 months ago
Does changes in liver always mean cancer
Hi My partner has cirrhosis and a spot on the liver which is monitored every 6 months. Following an ultrasound, more spots have now been identified and is going for an MRI and blood tests soon. I am very worried and was wondering if anyone has had a similar situation and does this always result in a
Hi My partner has cirrhosis and a spot on the liver which is monitored every 6 months. Following an ultrasound, more spots have now been identified and is going for an MRI and blood tests soon. I am very worried and was wondering if anyone has had a similar situation and does this always result in a
RainbowLover
in
British Liver Trust
4 months ago
Fibroscan – is it too early to be jubilant?
I do now feel like a fraud being here 😔 and my apologies to anybody here who feels I’ve created a storm in a teacup for myself and that I should clear the cyber waves for genuine issues. But in fairness to myself my GPs have been expressing serious concerns to me, I feel suggesting that I’m bound to
I do now feel like a fraud being here 😔 and my apologies to anybody here who feels I’ve created a storm in a teacup for myself and that I should clear the cyber waves for genuine issues. But in fairness to myself my GPs have been expressing serious concerns to me, I feel suggesting that I’m bound to
Trotter2024
in
British Liver Trust
4 months ago
Docetaxel Failing
Greetings from Inverness in the beautiful Highlands of Scotland! I would like to share my journey with you and hopefully get some advice on future treatments. In December 2022 following diagnoses of advanced prostate cancer with multiple bone metastasis I started zytiga + prednisone and 6 monthly triptorelin
Greetings from Inverness in the beautiful Highlands of Scotland! I would like to share my journey with you and hopefully get some advice on future treatments. In December 2022 following diagnoses of advanced prostate cancer with multiple bone metastasis I started zytiga + prednisone and 6 monthly triptorelin
Fisherman2
in
Advanced Prostate Cancer
4 months ago
Severe cirrhosis, any hope?
My father is in hospital with severe cirrhosis. He has been drinking a litre of vodka a day for 2 years. It sounds silly but none of us knew about it. He never seemed drunk. We are beating ourselves up wishing we could have intervened sooner. We phoned his DR after finding the empty bottles and he was
My father is in hospital with severe cirrhosis. He has been drinking a litre of vodka a day for 2 years. It sounds silly but none of us knew about it. He never seemed drunk. We are beating ourselves up wishing we could have intervened sooner. We phoned his DR after finding the empty bottles and he was
Puddles0
in
British Liver Trust
4 months ago
Appropriate Treatment
I was diagnosed with stage 4 prostate cancer PSA 29.1 which had metastatised to lymph nodes, ribs & spine after a few months on Abiraterone and Prednisone my PSA count dropped to 0.06 After 30 months my PSA started to rise at 10.2 my treatment was declared ineffective Lutetium 177 treatment was recommended
I was diagnosed with stage 4 prostate cancer PSA 29.1 which had metastatised to lymph nodes, ribs & spine after a few months on Abiraterone and Prednisone my PSA count dropped to 0.06 After 30 months my PSA started to rise at 10.2 my treatment was declared ineffective Lutetium 177 treatment was recommended
154Eleventh
in
Advanced Prostate Cancer
4 months ago
Wednesday's Word
[i]
Autoimmune hepatitis (AIH)
[/i] This is an autoimmune disease where the attack is on the hepatocytes (cells of the liver) rather than the biliary cells (bile ducts). It presents very differently and is treated very differently as well. When both diseases are present this is called 'AIH overlap
[i]
Autoimmune hepatitis (AIH)
[/i] This is an autoimmune disease where the attack is on the hepatocytes (cells of the liver) rather than the biliary cells (bile ducts). It presents very differently and is treated very differently as well. When both diseases are present this is called 'AIH overlap
DonnaBoll
Administrator
in
PBC Foundation
1 month ago
Ureter Restriction from Radiation Treatments?
While I don't have any symptoms (yet), a CT scan and ultrasound tests show that the lower part of my right ureter tube is very narrow and causing the kidney to swell, apparently from restricted flow of urine through the ureter. My University of Chicago Medicine urologist suspects scarring in the ureter
While I don't have any symptoms (yet), a CT scan and ultrasound tests show that the lower part of my right ureter tube is very narrow and causing the kidney to swell, apparently from restricted flow of urine through the ureter. My University of Chicago Medicine urologist suspects scarring in the ureter
Polaris1
in
Advanced Prostate Cancer
4 months ago
10th year
Ten years ago I had my Gleason 9 prostate removed. PSA was .1 for a while. It crept up over .2, and I began taking lupron. The drug brought PSA back down to >.01 for a year or so. As the level started going up again, I received whole pelvis bed radiation, moving PSA to undetectable. After a year or so
Ten years ago I had my Gleason 9 prostate removed. PSA was .1 for a while. It crept up over .2, and I began taking lupron. The drug brought PSA back down to >.01 for a year or so. As the level started going up again, I received whole pelvis bed radiation, moving PSA to undetectable. After a year or so
Jvaughan0
in
Advanced Prostate Cancer
4 months ago
PSA Rising After PBRT
Underwent prostate bed radiation in 2022 with good results — about a year of PSA at .02 to .05 — past six months, .09 and now at .17 Will get a PSMA-PET, but am curious what’s next ??
Underwent prostate bed radiation in 2022 with good results — about a year of PSA at .02 to .05 — past six months, .09 and now at .17 Will get a PSMA-PET, but am curious what’s next ??
FLRichardson
in
Advanced Prostate Cancer
4 months ago
Cortisol blood test
What time in the morning would be best to catch low cortisol if I have it?
What time in the morning would be best to catch low cortisol if I have it?
Clara9
in
Thyroid UK
4 months ago
Cortisol issues
I'm fortunate in having a good GP who is very concerned about my total exhaustion and inability to cope with everyday life. She wrote to my rheumy who authorised a 9am cortisol test. It came back as 104 and he has arranged a short synacthen test in two months time. I've asked the rheumatology dept for
I'm fortunate in having a good GP who is very concerned about my total exhaustion and inability to cope with everyday life. She wrote to my rheumy who authorised a 9am cortisol test. It came back as 104 and he has arranged a short synacthen test in two months time. I've asked the rheumatology dept for
Sammo47
in
PMRGCAuk
4 months ago
Improving Symptoms with Rising PSA
If prostate symptoms [i]
(less urinary frequency/less urgent urination/finally can sleep through night)
[/i] are improving, but PSA is increasing
(from 10 to15)
over last few years where at
10
MRI was negative, what does kind of pattern indicate or suggests?
If prostate symptoms [i]
(less urinary frequency/less urgent urination/finally can sleep through night)
[/i] are improving, but PSA is increasing
(from 10 to15)
over last few years where at
10
MRI was negative, what does kind of pattern indicate or suggests?
back2health
in
Advanced Prostate Cancer
4 months ago
Billiry attresia
My Son is 9 weeks old, had the kasai operation when he was 6 weeks old his eyes are still a bit yellowish Stool is light yellow and he poop every feed. doctors said that they found mild to moderate fibrosis in his biopsy report . i wanted to know about mild to moderate fibrosis . anyone had this kind
My Son is 9 weeks old, had the kasai operation when he was 6 weeks old his eyes are still a bit yellowish Stool is light yellow and he poop every feed. doctors said that they found mild to moderate fibrosis in his biopsy report . i wanted to know about mild to moderate fibrosis . anyone had this kind
srajeshwari53
in
Children's Liver Disease Foundation
4 months ago
Please help us decide on next treatment
Hi, my Dad was diagnosed back in 2021 with stage IV, Gleason 9, oligometastatic. He had 6 weeks of radiation at the time of diagnosis and has been for the past 2.5 years on Abiraterone, Prednisone and Lupron. As I mentioned in my prior post my Dad’s PSA started going up. He had a PSMA Pet scan and it
Hi, my Dad was diagnosed back in 2021 with stage IV, Gleason 9, oligometastatic. He had 6 weeks of radiation at the time of diagnosis and has been for the past 2.5 years on Abiraterone, Prednisone and Lupron. As I mentioned in my prior post my Dad’s PSA started going up. He had a PSMA Pet scan and it
Simonapo
in
Advanced Prostate Cancer
4 months ago
Introduction to our newer members
Hi - and welcome! My name is Donna - I facilitate this support group for The PBC Foundation - Health Unlocked. First of all, take a breath. It’s ok. We all, myself included, have been exactly where you are right now…. scared, unsure, mad, sad, and so much more. Stop googling for information - get your
Hi - and welcome! My name is Donna - I facilitate this support group for The PBC Foundation - Health Unlocked. First of all, take a breath. It’s ok. We all, myself included, have been exactly where you are right now…. scared, unsure, mad, sad, and so much more. Stop googling for information - get your
DonnaBoll
Administrator
in
PBC Foundation
4 months ago
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