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Meta analysis of Eastern Cooperative Oncology Group(ECOG) PS predicts OS regardless of category, previous chemotherapy, and mPC population
”Overall, 75 studies, comprising 32,298 patients, were included. Most studies (72/75) included patients with mCRPC. Higher ECOG PS was associated with a significant increase in mortality risk, with the highest estimate observed among patients with mCRPC with an ECOG PS of ≥2 versus <2 (hazard ratio [
”Overall, 75 studies, comprising 32,298 patients, were included. Most studies (72/75) included patients with mCRPC. Higher ECOG PS was associated with a significant increase in mortality risk, with the highest estimate observed among patients with mCRPC with an ECOG PS of ≥2 versus <2 (hazard ratio [
Graham49
in
Advanced Prostate Cancer
3 months ago
Some good advancements today too: Advances in Engineered Macrophages - A New Frontier in Cancer Immunotherapy
"These cells act synergistically in tumour progression, invasion, metastasis, and response to immunotherapies. Consequently, cancer treatment has transitioned from a model centred solely on the cancer itself to one focused on the
tumour microenvironment
, and cancer immunotherapy has consequently
"These cells act synergistically in tumour progression, invasion, metastasis, and response to immunotherapies. Consequently, cancer treatment has transitioned from a model centred solely on the cancer itself to one focused on the
tumour microenvironment
, and cancer immunotherapy has consequently
Maxone73
in
Advanced Prostate Cancer
3 months ago
PSMA and bladder Cancer?
I have been having various difficulties with urination and know that my bladder is messed up. I have radiation cystitis and who knows what else. I saw my urologist recently and he had little to offer, sort of said yes you are a mess and pretty much left it at that. I have had PSMA pet scans and SPECT
I have been having various difficulties with urination and know that my bladder is messed up. I have radiation cystitis and who knows what else. I saw my urologist recently and he had little to offer, sort of said yes you are a mess and pretty much left it at that. I have had PSMA pet scans and SPECT
spencoid2
in
Advanced Prostate Cancer
3 months ago
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IBS. Possible internal bowel prolapse,inturrssusception or bowel / bladder intracele
hi, I’m new here and this is my first post( spend a lot of time on fibro & auto immune site!) I’m having an awful time of it bowel wise atm… and for som 24 months or more but so much so that I’ve actually paid and seen a private colorectal surgeon( female) I have this weird awful sensation of constantly
hi, I’m new here and this is my first post( spend a lot of time on fibro & auto immune site!) I’m having an awful time of it bowel wise atm… and for som 24 months or more but so much so that I’ve actually paid and seen a private colorectal surgeon( female) I have this weird awful sensation of constantly
Beakybird58
in
IBS Network
3 months ago
Satisfaction with AUS after Radiation
If you have had an AUS implanted after receiving radiation are you satisfied with your decision and has it improved your quality of life? Or do you regret having an AUS implanted and if so why? I have had both a prostatectomy and salvage radiation (see profile). I regained continence after the prostatectomy
If you have had an AUS implanted after receiving radiation are you satisfied with your decision and has it improved your quality of life? Or do you regret having an AUS implanted and if so why? I have had both a prostatectomy and salvage radiation (see profile). I regained continence after the prostatectomy
Alturia
in
Advanced Prostate Cancer
3 months ago
Neurofibroma
Not thyroid related, but has anyone experienced under skin neurofibroma? Trying to figure out whether to have it removed or not. No pain, but wondering if it shall get bigger in size.
Not thyroid related, but has anyone experienced under skin neurofibroma? Trying to figure out whether to have it removed or not. No pain, but wondering if it shall get bigger in size.
Huskyy
in
Thyroid UK
3 months ago
IMRT WITHOUT THE JELL
I'm scheduled for IMRT Radistion without the jell. Doc says the jell may push cancer microscopic cells away from the prostate. He said the cancer is about to protrude through the capsule and microsopic cancer cells could be out of the capsule and did not want to take a chance of putting the jell in and
I'm scheduled for IMRT Radistion without the jell. Doc says the jell may push cancer microscopic cells away from the prostate. He said the cancer is about to protrude through the capsule and microsopic cancer cells could be out of the capsule and did not want to take a chance of putting the jell in and
woppaginny
in
Advanced Prostate Cancer
3 months ago
men’s freedom condom catheter
since requiring a catheter about a year ago due to total incontinence ten years after RP and SRT, I’ve been unable to stop leakage around Foley catheter. This has necessitated using multiple depend briefs and guards daily. so I’m about to try Men’s Freedom condom catheter and wonder if any warriors
since requiring a catheter about a year ago due to total incontinence ten years after RP and SRT, I’ve been unable to stop leakage around Foley catheter. This has necessitated using multiple depend briefs and guards daily. so I’m about to try Men’s Freedom condom catheter and wonder if any warriors
Break60
in
Advanced Prostate Cancer
3 months ago
Caffeic acid phenethyl ester (CAPE) is an ingredient in bee propolis. See below for invitro and mice evidence for inhibition AR-V7 by CAPE
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Human studies needed. Caffeic acid phenethyl ester suppresses the expression of androgen receptor variant 7 via inhibition of CDK1 and AKT Ying-Yu Kuo, Chieh Huo, Chia-Yang Li & Chih-Pin Chuu Cancer Gene Therapy (2024) doi: 10.1038/s41417-024-00753-z Abstract Androgen receptor (AR) splice variant
Graham49
in
Advanced Prostate Cancer
3 months ago
Dense adhesions after 15 surgeries, + 2 rare medical conditions
At the age of 25, my life changed forever. After 4 years, 2 surgeries and no diagnosis, as to what the problems was, I eventually found out I had multiple intestinal lipomatosis and Ehlers Danlos Syndrome. Ileostomy formed 1996. 13 more surgeries have performed. Due to absorption problems, + major
At the age of 25, my life changed forever. After 4 years, 2 surgeries and no diagnosis, as to what the problems was, I eventually found out I had multiple intestinal lipomatosis and Ehlers Danlos Syndrome. Ileostomy formed 1996. 13 more surgeries have performed. Due to absorption problems, + major
Eegmetem
in
Pelvic Pain Support Network
3 months ago
FDG elements of PSMA scan
I had a FDG scan a few days ago . At the heart of my confusion is the function of FDG in giving a positive outcome to Pluvicto infusions. Is it a good thing to have lots of 'FDG Avid' showing up, or do you want those aspects of the scan to be as hidden as possible (so that the PSMA -Avid cells can be
I had a FDG scan a few days ago . At the heart of my confusion is the function of FDG in giving a positive outcome to Pluvicto infusions. Is it a good thing to have lots of 'FDG Avid' showing up, or do you want those aspects of the scan to be as hidden as possible (so that the PSMA -Avid cells can be
CrocodileShoes
in
Advanced Prostate Cancer
3 months ago
Pluvicto Question
Hi Fellow Warriors! Six months of Taxotere failed miserably. After 8 rounds, I was done. After chemo, my second PSMA-PET showed additional bone mets and a spread to the lymph nodes. My MO told me I was a good candidate for Pluvicto, so, three months after finishing Taxotere, I started that therapy
Hi Fellow Warriors! Six months of Taxotere failed miserably. After 8 rounds, I was done. After chemo, my second PSMA-PET showed additional bone mets and a spread to the lymph nodes. My MO told me I was a good candidate for Pluvicto, so, three months after finishing Taxotere, I started that therapy
MJCA
in
Advanced Prostate Cancer
3 months ago
CGA and urogram
Hi All good advisers. Have been on pred for CGA since July 2023, starting at 60mg. now at 12 mg with very slow taper. I am having a kidney urogram this April. I am also on metformin 3 x daily 500 mg. I have read that I should stop taking metformin before this procedure. How many days before should
Hi All good advisers. Have been on pred for CGA since July 2023, starting at 60mg. now at 12 mg with very slow taper. I am having a kidney urogram this April. I am also on metformin 3 x daily 500 mg. I have read that I should stop taking metformin before this procedure. How many days before should
Groda
in
PMRGCAuk
3 months ago
How do you contact your Rheumatologist?
Hi lovely Lupies. Just a quick question to people in the UK regarding how you make contact with your Rheumy? I have never tried to contact my Rheumy here in `wales previously but at my last two appointments he said if you are struggling with flares contact me. Well since coming out if hospital I am
Hi lovely Lupies. Just a quick question to people in the UK regarding how you make contact with your Rheumy? I have never tried to contact my Rheumy here in `wales previously but at my last two appointments he said if you are struggling with flares contact me. Well since coming out if hospital I am
CecilyParsley
in
LUPUS UK
3 months ago
Bilateral frontal calvarial metastases
Has anyone in the forum experienced bilateral frontal calvarial metastases associated with their PCa? I recently had a brain MRI where this metastases was identified. The assessing physicians impression was that there is no worrisome parenchymal or leptomeningeal enhancement and did not recommend any
Has anyone in the forum experienced bilateral frontal calvarial metastases associated with their PCa? I recently had a brain MRI where this metastases was identified. The assessing physicians impression was that there is no worrisome parenchymal or leptomeningeal enhancement and did not recommend any
kklott01
in
Advanced Prostate Cancer
3 months ago
Fennel Seeds
Hi everyone, I've recently done some research into fennel seeds, and I've read that apparently it contains a compound called Anethole, which helps to relax the muscles in your digestive tract. I was just wondering if anyone here has eaten fennel seeds before and can verify this. I am looking for ways
Hi everyone, I've recently done some research into fennel seeds, and I've read that apparently it contains a compound called Anethole, which helps to relax the muscles in your digestive tract. I was just wondering if anyone here has eaten fennel seeds before and can verify this. I am looking for ways
Crescendo251
in
IBS Network
3 months ago
Potential biochemical recurrence post radical prostatectomy, looking for perspective on the outcomes and treatments.
63-year old Male, months shy of 5-year mark of the radical prostatectomy, showed PSA of .08 in January then .07 in March. Originally had up to Gleason 9’s. I know it’s not technically a recurrence until .2, and doubling time is the next variable to look out for. But what else should we keep in mind
63-year old Male, months shy of 5-year mark of the radical prostatectomy, showed PSA of .08 in January then .07 in March. Originally had up to Gleason 9’s. I know it’s not technically a recurrence until .2, and doubling time is the next variable to look out for. But what else should we keep in mind
Stevescut
in
Advanced Prostate Cancer
3 months ago
Lymph node Metastasis
After 7 years, and multiple PSMA scans, my husband had a FDG CT scan and it showed what they quoted as “several” metastasis In the lymphs In the para aortic area in abdomen. One doc wants to biopsy to check if cancer DNA has changed from original pathology in 2017. Another doc says… No to biopsy due
After 7 years, and multiple PSMA scans, my husband had a FDG CT scan and it showed what they quoted as “several” metastasis In the lymphs In the para aortic area in abdomen. One doc wants to biopsy to check if cancer DNA has changed from original pathology in 2017. Another doc says… No to biopsy due
JolleySprings
in
Advanced Prostate Cancer
3 months ago
Help with Results
I just updated my Bio and just received my PSMA Gallium scan results. Appointment is tomorrow to review but from what I see even with a low PSA of 0.052 a lymph node lit up which is rare. Is this correct and given this my guess SOC is whole pelvic adjuvant radiation and higher dose to lymph nodes or?
I just updated my Bio and just received my PSMA Gallium scan results. Appointment is tomorrow to review but from what I see even with a low PSA of 0.052 a lymph node lit up which is rare. Is this correct and given this my guess SOC is whole pelvic adjuvant radiation and higher dose to lymph nodes or?
Peppertree602
in
Advanced Prostate Cancer
3 months ago
Spinal uptake
Afternoon fellow warriors, after a recent Pet scan they have found 2 spots one on my upper spine and the other on my neck.My Oncologist is worried having radiotherapy on my neck maybe to close to the spinal cord should I be worried that this is the case. She is suggesting I just move into a different
Afternoon fellow warriors, after a recent Pet scan they have found 2 spots one on my upper spine and the other on my neck.My Oncologist is worried having radiotherapy on my neck maybe to close to the spinal cord should I be worried that this is the case. She is suggesting I just move into a different
Chubby42
in
Advanced Prostate Cancer
3 months ago
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