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PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
Here is one out of far left field https://www.frontiersin.org/articles/10.3389/fphar.2021.692574/full PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy www.frontiersin.orgSi-Min Qi1†, www.frontiersin.orgJinyun Dong2†, www.frontiersin.orgZhi-Yuan Xu2, www.frontiersin.orgXiang-Dong
Here is one out of far left field https://www.frontiersin.org/articles/10.3389/fphar.2021.692574/full PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy www.frontiersin.orgSi-Min Qi1†, www.frontiersin.orgJinyun Dong2†, www.frontiersin.orgZhi-Yuan Xu2, www.frontiersin.orgXiang-Dong
Scout4answers
in
Advanced Prostate Cancer
2 years ago
Progesterone Receptor.
It belongs to the same receptor family as the androgen- and
oestrogen
receptors, which are expressed in both stromal and tumor cells of the PCa tissue. Currently, there is a general agreement of PGR presence in the stromal cells of PCa.
It belongs to the same receptor family as the androgen- and
oestrogen
receptors, which are expressed in both stromal and tumor cells of the PCa tissue. Currently, there is a general agreement of PGR presence in the stromal cells of PCa.
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Hormones 101 Please?
Would some kind person direct me to where I may read of the comparison of various forms of estrogen please? I see others talking of oestrogel and I do not know what that is or the advantage. I am so out of the loop last few years. You know everything seems to level off and u reach a comfortable place
Would some kind person direct me to where I may read of the comparison of various forms of estrogen please? I see others talking of oestrogel and I do not know what that is or the advantage. I am so out of the loop last few years. You know everything seems to level off and u reach a comfortable place
jdplum
in
Thyroid UK
2 years ago
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What blood tests for Hypo?
Hi folks, Still on my diagnosis journey (4 years in 🙈). I’m going to organise bloods this week and want to make sure my GP requests the right tests. I think I need the following: TSH- is ultra sensitive TSH the same thing? Free T3 Free T4 Vitamin D As I have anemia I’ll also test Ferritin B12 As I
Hi folks, Still on my diagnosis journey (4 years in 🙈). I’m going to organise bloods this week and want to make sure my GP requests the right tests. I think I need the following: TSH- is ultra sensitive TSH the same thing? Free T3 Free T4 Vitamin D As I have anemia I’ll also test Ferritin B12 As I
Jogger24
in
Thyroid UK
2 years ago
Poor T3 conversion
Last took levo morning before test (not on day of test which I did fasted at 9am) Incidentally showed my
oestrogen
levels are way too high too. Vit D low at 77.0 Have been folate anaemic in the past but that wasn’t tested here.
Last took levo morning before test (not on day of test which I did fasted at 9am) Incidentally showed my
oestrogen
levels are way too high too. Vit D low at 77.0 Have been folate anaemic in the past but that wasn’t tested here.
Gymbunni
in
Thyroid UK
2 years ago
MEGASE - treatment with progesterone
Hello brave women, I haven't written for a while but do routinely check in to see what's happening with everyone. A little history, I had breast cancer at 45 and then again as MBC to bone only in 2013. So I'll start my 10th year this June. Lots and lots of different treatments, including within the
Hello brave women, I haven't written for a while but do routinely check in to see what's happening with everyone. A little history, I had breast cancer at 45 and then again as MBC to bone only in 2013. So I'll start my 10th year this June. Lots and lots of different treatments, including within the
Lnlc
in
SHARE Metastatic Breast Cancer
2 years ago
Diagnosed but…. What now?
Heard about Body identical (yam root), transdermal
oestrogen
and an oral capsule called Utrogestan. Plus maybe testosterone replacement for energy. Anyone on this? Confused.com
Heard about Body identical (yam root), transdermal
oestrogen
and an oral capsule called Utrogestan. Plus maybe testosterone replacement for energy. Anyone on this? Confused.com
Guineafowlrach
in
Endometriosis UK
2 years ago
And the Results are in.....
Hello Following on from my post last weekend, just as I was about to order private tests, the Doctor texted me at 5pm yesterday with T3 and Vitamin D results taken on same sample drawn on 25th March. So full results for that date are: TSH 0.10 (0.27-4.20) -4.33% Free T4 20.00 (10.5-22.0) 82.61% Total
Hello Following on from my post last weekend, just as I was about to order private tests, the Doctor texted me at 5pm yesterday with T3 and Vitamin D results taken on same sample drawn on 25th March. So full results for that date are: TSH 0.10 (0.27-4.20) -4.33% Free T4 20.00 (10.5-22.0) 82.61% Total
Galwayed
in
Thyroid UK
2 years ago
Failed FET. What to do next? What to ask for?
This has probably been asked 101 times but I hope you don't mind me asking again. So far I have had 2 Frozen Embryo Transfers first one ended in early miscarriage and 2nd one didn't take. The first time I was on oral estrogen 2x 2mg three times a day and 2x 200mg progesterone pessaries twice a day
This has probably been asked 101 times but I hope you don't mind me asking again. So far I have had 2 Frozen Embryo Transfers first one ended in early miscarriage and 2nd one didn't take. The first time I was on oral estrogen 2x 2mg three times a day and 2x 200mg progesterone pessaries twice a day
JadeH92
in
Fertility Network UK
2 years ago
The Patch Trial...The Verdict is in!
Transdermal administration of oestradiol (tE2) circumvents first-pass hepatic metabolism and, therefore, should avoid the cardiovascular toxicity seen with oral
oestrogen
and the
oestrogen
-depletion effects seen with luteinising hormone releasing hormone agonists (LHRHa).
Transdermal administration of oestradiol (tE2) circumvents first-pass hepatic metabolism and, therefore, should avoid the cardiovascular toxicity seen with oral
oestrogen
and the
oestrogen
-depletion effects seen with luteinising hormone releasing hormone agonists (LHRHa).
E2-Guy
in
Advanced Prostate Cancer
2 years ago
Help please with female hormones after intro of T3 and gel to patches
Hello I know this isn’t directly thyroid related but I needed a bit of help/ advice with recent sex hormone results. I started on T3 approximately 8 weeks ago and still adjusting dosing with guidance from an Endo. 5 weeks ago, I changed from 3 pumps of estrogel to 100mcg patches as I felt I wanted
Hello I know this isn’t directly thyroid related but I needed a bit of help/ advice with recent sex hormone results. I started on T3 approximately 8 weeks ago and still adjusting dosing with guidance from an Endo. 5 weeks ago, I changed from 3 pumps of estrogel to 100mcg patches as I felt I wanted
Hidden
in
Thyroid UK
2 years ago
Anyone Having to change to Verzenio
Hi Ladies, My PET shows bone only disease is stable but markers were up and I have this lymph node in neck that is bulging again. So we quickly changed from Ibrance/ faslodex to Verzenio/ aromasin. Onc says she is trying to get more time( just 18 months so far) out of the CDK 4-6 class before the rear
Hi Ladies, My PET shows bone only disease is stable but markers were up and I have this lymph node in neck that is bulging again. So we quickly changed from Ibrance/ faslodex to Verzenio/ aromasin. Onc says she is trying to get more time( just 18 months so far) out of the CDK 4-6 class before the rear
Bettybuckets
in
SHARE Metastatic Breast Cancer
2 years ago
Medicated FET protocol - too short?
I started
oestrogen
(Elleste) meds for my transfer on day 2 of my cycle. We are hoping to do FET on short protocol. I had my day 9 scan today and my lining has increased from approx 6.1 to 7.1.
I started
oestrogen
(Elleste) meds for my transfer on day 2 of my cycle. We are hoping to do FET on short protocol. I had my day 9 scan today and my lining has increased from approx 6.1 to 7.1.
Robins53
in
Fertility Network UK
2 years ago
Estrogen Blocker - Anastrozole
Hello Teal Sisters, This is an ongoing dilemma for me would appreciate your input and personal experience with estrogen blockers. My Gyno/Onc wants me to take the above 1mg for 2 years my Oncologist doesn't recommend it because there's no proven data behind it in my type, I'm 3B, Low Grade, Endometrioid
Hello Teal Sisters, This is an ongoing dilemma for me would appreciate your input and personal experience with estrogen blockers. My Gyno/Onc wants me to take the above 1mg for 2 years my Oncologist doesn't recommend it because there's no proven data behind it in my type, I'm 3B, Low Grade, Endometrioid
Saintgermain
in
My Ovacome
2 years ago
Latest Details on Approval of Oral SERDS - In Place of Faslodex Shots
Hi Fellow MBC’ers: Here is the latest I could find on the approval status of the long-awaited oral SERDs to replace those painful Faslodex shots: Patients with estrogen receptor–positive, HER2-negative advanced or metastatic breast cancer experienced a progression-free survival benefit after being treated
Hi Fellow MBC’ers: Here is the latest I could find on the approval status of the long-awaited oral SERDs to replace those painful Faslodex shots: Patients with estrogen receptor–positive, HER2-negative advanced or metastatic breast cancer experienced a progression-free survival benefit after being treated
hopenowandtomorrow
in
SHARE Metastatic Breast Cancer
2 years ago
Qlaira pills
hello everyone! first of all, I hope this message is not inaccurate. I previously asked two moderators about it but as I didn't get a response I decided to take the risk. I don't know if anyone else had the same problem I faced when trying to buy Qlaira pills here (a combined oral contraceptive pill
hello everyone! first of all, I hope this message is not inaccurate. I previously asked two moderators about it but as I didn't get a response I decided to take the risk. I don't know if anyone else had the same problem I faced when trying to buy Qlaira pills here (a combined oral contraceptive pill
btx525
in
Endometriosis UK
2 years ago
My menopause symptoms have started to come back. Could it be that my body's naturally produced hormones have reduced?
I wanted to ask if these symptoms are due to my natural hormones depleting and if it was possible to either increase my Tibolone or add an
oestrogen
patch alongside my Tibolone. Has anyone been in this situation and what did you change?
I wanted to ask if these symptoms are due to my natural hormones depleting and if it was possible to either increase my Tibolone or add an
oestrogen
patch alongside my Tibolone. Has anyone been in this situation and what did you change?
WendyW1964
in
Thyroid UK
2 years ago
Went to the doctor today:
Well I was taken seriously at the Dr today. I am going now ….. to a specialist She has ordered ultrasounds Lab work (ok I’m used to that). She said endometriosis doesn’t show up on anything but laparoscopic tests. She said let’s get to the bottom of this . I swear she had tears in her eyes. (Slight
Well I was taken seriously at the Dr today. I am going now ….. to a specialist She has ordered ultrasounds Lab work (ok I’m used to that). She said endometriosis doesn’t show up on anything but laparoscopic tests. She said let’s get to the bottom of this . I swear she had tears in her eyes. (Slight
mimilover
in
Endometriosis UK
2 years ago
Stopping oestrogen after BFP
Clinic stopped
oestrogen
meds after 7 week scan and she is now very emotional and irritable. Has anyone else experienced this? Should she have been weaned off? She is still taking progesterone pessaries . Thanks x
Clinic stopped
oestrogen
meds after 7 week scan and she is now very emotional and irritable. Has anyone else experienced this? Should she have been weaned off? She is still taking progesterone pessaries . Thanks x
1980Neil
in
Fertility Network UK
3 years ago
Help! Blood results give unexpected drop in % through range of Free T4, Free T3 and quite an increase in TSH
* My mood was low -endo prescribed HRT, it didn't suit, mood worsened * Spoke to an understanding Female GP on the phone as I was constantly crying, she agreed HRT was a great move but said there were far more modern options, I have been on
oestrogen
and inserting Utrogestan since and settled although
* My mood was low -endo prescribed HRT, it didn't suit, mood worsened * Spoke to an understanding Female GP on the phone as I was constantly crying, she agreed HRT was a great move but said there were far more modern options, I have been on
oestrogen
and inserting Utrogestan since and settled although
Levo50
in
Thyroid UK
2 years ago
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