Hi Fellow MBC’ers: Here is the latest I could find on the approval status of the long-awaited oral SERDs to replace those painful Faslodex shots:
Patients with estrogen receptor–positive, HER2-negative advanced or metastatic breast cancer experienced a progression-free survival benefit after being treated with elacestrant. cancernetwork.com/view/firs...
Does anyone else have additional information?
Thank you!
❤️🙏❤️
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hopenowandtomorrow
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hi. great news! and i like that it can be taken alone and not a combo....if i read it correctly. the sooner the better. thanks for sharing this....carole xo
after 4.5 years on letrozole only (first tx), will be switching to faslodex injections next week! so bring on the 'oral' SERDS👍😊
Hi hopenowandtomoorrow!
That's great news, thank you for sharing!
And I do have what might be additional information!
I've read here, in this community, that the new oral SERD might be even more effective than the injections. In *my mind* (a very fuzzy place...) this could be because we'd be getting an equal dose throughout the month, vs. an injection, spike, recession (?)...so a more steady dosage? I do make this stuff up, but it seems logical?
At my last visit, two months ago, my doc mentioned switching me to the oral version....I see her again in a few weeks and will say that I'm on board with this! I love my Faslo and want to keep it going as long as possible!
Again, thanks for sharing....such great intel on this board!
Thank you so much for sharing. The interim results look very promising. The final efficacy analysis will be available later in the year. Hopefully, they’ll be positive as well. There was very little safety data that I could found. The most common adverse event was nausea/vomiting which could be managed.
We need to hang up there for the new therapies that will give us more time!
I've spoke with my Onc about this drug, she thinks it will take at least another year for its FDA approval. I have been on Faslodex only now for 5 yrs and I really hope this drug is ready to go if Faslo loses its punch as she also said its shows better results than Faslodex alone.
I have been taking Faslodex injections for five years now and my injection sites are horrible. Infections skin irritations everything you name it pain. So they just ordered the real name brand faslodex by Astra Zeneca throw pharmacy instead of using a generic. I’ve been on the generics now all different ones for the last three years and had nothing but problems with every single injection. Some were better than others but I always have a reaction that lasts until my next injection four weeks later. I go Tuesday which is a week late because I still have the irritation wrapping around from the injection to my hip. They ordered the real one I’m getting the real one on Tuesday. I will update and let everyone know if I got a reaction and if it made a difference . I am so looking forward to an oral surd.
I am so sorry you have to go through this each month. The shots are so painful and now it seems that the pain goes down my legs and weakens my legs. I feel like I walk crooked. From my last scan, I have lost an inch in height. Now I am 5’1” and my 12 year old grandson is taller than me. Of course, he loves that. My NP says it is because of compression in spine. 🙏🙏
Hello! I'm down to start a trial of an oral SERD in place of letrozole after my appointment in clinic on Wednesday, assuming no progression in last week's scan. Will keep you posted, Gill
Not yet - I think that they're looking for a new mutation that tells them the letrozole has stopped working and at that point they swap in the SERD and keep me on Palbo, testing the theory that it will extend the usefulness of P. Or I get the placebo... Anyway I had masses of blood taken last visit to clinic only to get a call a couple of weeks later saying I need to get the bloods drawn again, there'd been some mess up or anyway they didn't find what they needed. Upshot: feel a bit less excited about it all!
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