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Morgentaler Saturation Model: PSA vs Testosterone - Estrogen Patch vs Lupron ADT
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
This is a plot of % reduction in PSA from a Maximum Value versus Testosterone, for two different datasets: Estrogen Patch and Lupron ADT. Both curves (red and green lines) show a linear response starting from (0,0), up to about 200-250 ng/dL. Then, the lines curve over to a lower slope (especially
janebob99
in
Advanced Prostate Cancer
5 months ago
Another brother passes
My friend, George, passed this morning after a two year battle. He was DX'd at 85 with prostate cancer (PSA of 1200) behind his eye which spread to his brain. Failed ADT, chemo and Pluvicto. He was not on this forum. He was very active, skied 120 days a year, biked the rest. He and his wife went to
My friend, George, passed this morning after a two year battle. He was DX'd at 85 with prostate cancer (PSA of 1200) behind his eye which spread to his brain. Failed ADT, chemo and Pluvicto. He was not on this forum. He was very active, skied 120 days a year, biked the rest. He and his wife went to
gsun
in
Advanced Prostate Cancer
5 months ago
PSMA Scan to be scheduled - thank you Tall Allen
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
I want to thank Tall Allen for his suggestion that I see an oncologist. I had a RP followed by radiation in 2013. My PSA was undetectable until 2021, when it started to rise. This week I saw a radiation oncologist (whom I found through a friend) to ask him a lot of questions and to get his advice.
Geno2853
in
Advanced Prostate Cancer
5 months ago
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PSA-Nadir vs Testosterone-Nadir comparing Non-CRPC to CRPX men
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
janebob99
in
Advanced Prostate Cancer
5 months ago
PSA-Nadir vs Testosterone-Nadir
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
These plots show the linear relationship between median PSA-Nadir and median Testosterone-Nadir, pointing towards the Origin (i.e., 0 PSA-Nadir at 0 T-Nadir.). N= 38 men. The upper to graphs compare median PSA-nadir and median T-Nadir for Non-CRPC and CPRC groups (CPRC = Castrate Resistant Prostate
janebob99
in
Prostate Cancer Network
5 months ago
ADT response and questions for MO
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Hi, I am newish to this forum, still on a steep learning curve but I want to thank you for your contributions and discussions. This is my first time posting. My partner is 60 yrs old, as I understand it he had low PSA 3 yrs ago, not tested until Nov 2023, PSA50, stage 4, 1 met in 'sit' bone. Started
Lovecherries
in
Advanced Prostate Cancer
5 months ago
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
One questions doctors never seem to be able to answer is at what PSA level do you start to experience pain or physical problems? If you have had surgery, Salvage Radiation, ADT, SRBT and then stopped ADT with a continuing rise in you PSA when did you start to have pain or physical problems?
Exrunner
in
Advanced Prostate Cancer
5 months ago
New study validates intermittent hormone therapy
PCRI just posted a new video titled 'New study validates intermittent hormone therapy'. So, just search 'PCRI' in YouTube and that video will pop up. Certain individuals on this site feel strongly against curtailing the duration of hormone therapy from the standard 2 to 3 years or even longer. I urge
PCRI just posted a new video titled 'New study validates intermittent hormone therapy'. So, just search 'PCRI' in YouTube and that video will pop up. Certain individuals on this site feel strongly against curtailing the duration of hormone therapy from the standard 2 to 3 years or even longer. I urge
John347
in
Advanced Prostate Cancer
5 months ago
ARASENS Darolutamide vs Placebo
This Kaplan-Meier plot show the Castration - Resistant Prostate Cancer Free survival probability (%) for two groups: (A)
Darolutamide
+ ADT + Docetaxel, versus (B)
Placebo
+ ADT + Docetaxel, taken at two different times: 2 years and 4 years. There is a very large increase in survival
This Kaplan-Meier plot show the Castration - Resistant Prostate Cancer Free survival probability (%) for two groups: (A)
Darolutamide
+ ADT + Docetaxel, versus (B)
Placebo
+ ADT + Docetaxel, taken at two different times: 2 years and 4 years. There is a very large increase in survival
janebob99
in
Advanced Prostate Cancer
5 months ago
ARASENS TRIAL: Darolutamide
This Kaplan-Mieir plot show the Castration - Resistant Prostate Cancer Free survival probability (%) vs time for two groups: (A) Darolutamide + ADT + Docetaxel, versus (B) Placebo + ADT + Docetaxel. There is a very large increase in survival probability with the Darolutamide group (A) vs Placebo group
This Kaplan-Mieir plot show the Castration - Resistant Prostate Cancer Free survival probability (%) vs time for two groups: (A) Darolutamide + ADT + Docetaxel, versus (B) Placebo + ADT + Docetaxel. There is a very large increase in survival probability with the Darolutamide group (A) vs Placebo group
janebob99
in
Advanced Prostate Cancer
5 months ago
ADT with radiation?
I have a G 4+3, considered to be unfavorable intermediate risk, but a Decipher score of .4, considered to be low risk. I have opted to have radiation to treat my PCa. Do I need to take ADT with the radiation therapy? My MO suggested 4 to 6 months of Orgavix (not sure if I'm spelling it correctly). If
I have a G 4+3, considered to be unfavorable intermediate risk, but a Decipher score of .4, considered to be low risk. I have opted to have radiation to treat my PCa. Do I need to take ADT with the radiation therapy? My MO suggested 4 to 6 months of Orgavix (not sure if I'm spelling it correctly). If
CBRD
in
Advanced Prostate Cancer
5 months ago
life Insurance
I wanted to get opinions regarding my life insurance 800K which will be expiring in a couple of months. I have the option to roll it over to a universal policy but it’s going to cost me 2K a month. I’m still Homone sensitive. And been on ADT and Nubeqa (daroludimide) for the last couple of years. Had
I wanted to get opinions regarding my life insurance 800K which will be expiring in a couple of months. I have the option to roll it over to a universal policy but it’s going to cost me 2K a month. I’m still Homone sensitive. And been on ADT and Nubeqa (daroludimide) for the last couple of years. Had
JDKotter
in
Advanced Prostate Cancer
5 months ago
ISO a third MO opinion for my dad
Hi all! My dad was diagnosed with pca in 2021, prostate removal that summer. After radical - was told no treatment necessary and lo and behold January the following year psa went from .04 to 1.2 in 3 months. Put on adt and zytiga (not sure of spelling), scans show pelvic bed spots and 1 on s1, radiation
Hi all! My dad was diagnosed with pca in 2021, prostate removal that summer. After radical - was told no treatment necessary and lo and behold January the following year psa went from .04 to 1.2 in 3 months. Put on adt and zytiga (not sure of spelling), scans show pelvic bed spots and 1 on s1, radiation
Dsmejkal88
in
Advanced Prostate Cancer
5 months ago
Dr Dipnarine Maharaj Immune Regenerative Medicine in Boynton Beach FL
Has anyone heard of him? I am about to start ADT and salvage radiation in 2 months (PSA 0.052) . So in mean time I was going to check him out and wondered if anyone who does a ton of research has heard of him?
Has anyone heard of him? I am about to start ADT and salvage radiation in 2 months (PSA 0.052) . So in mean time I was going to check him out and wondered if anyone who does a ton of research has heard of him?
Peppertree602
in
Advanced Prostate Cancer
5 months ago
New 2024 AUA/ASTRO/SUO Guidelines for Salvage Therapy
https://www.auanet.org/guidelines-and-quality/guidelines/salvage-therapy-for-prostate-cancer Not surprising. I think they should recommend adjuvant ADT at a PSA≥0.35 instead of ≥0.7 because I think patients are hoping for curative SRT and not just equivalent survival. https://www.prostatecancer.news
https://www.auanet.org/guidelines-and-quality/guidelines/salvage-therapy-for-prostate-cancer Not surprising. I think they should recommend adjuvant ADT at a PSA≥0.35 instead of ≥0.7 because I think patients are hoping for curative SRT and not just equivalent survival. https://www.prostatecancer.news
Tall_Allen
in
Advanced Prostate Cancer
5 months ago
PSA doubled in last 30 days after 4 months stable since Provenge. What's next?
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
Update: PSA remained roughly 1.7 to 1.8 for last 4 months after Provenge but yesterday's 30-day PSA test revealed a jump to 3.190 so something is growing quick. I have been off of all ADT since finishing fourth LU-177 injection five months ago and one SBRT treatment 4 months ago. After LU-177, PSA
SViking
in
Advanced Prostate Cancer
5 months ago
my first post
Hello there, I’ve been dealing with this since 1/2015. I’ve had brachytherapy, chemotherapy, hormone therapy, cyber knife, immunotherapy, more chemotherapy, now taking Everolimus and letrozole. I’ve always felt that this was a chronic disease after the medications stopped working onto the next regimen
Hello there, I’ve been dealing with this since 1/2015. I’ve had brachytherapy, chemotherapy, hormone therapy, cyber knife, immunotherapy, more chemotherapy, now taking Everolimus and letrozole. I’ve always felt that this was a chronic disease after the medications stopped working onto the next regimen
Sabrina02
in
SHARE Uterine Cancer Support
5 months ago
PSA vs Testosterone Nadir for CRPC and Non-CRPC
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
This plot from Safriadi (2022) compares the mean values of PSA nadir versus Testosterone Nadir comparing Non-Castrate Resistant PC (Non-CRPC) to Castrate-Resistant PC (CRPC) men. For Non-CRPC men, the range of T-nadir was 2.5-49 ng/dL (mean = 21) and range for PSA nadir was 0.02-9 ng/mL (mean=2). For
janebob99
in
Advanced Prostate Cancer
5 months ago
Rising PSA post RP,IRT,ADT
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
Have 2 consecutive rising PSA - .04,.05,.1. Year post RP,IRT,ADT.. understand if goes to .2 new scans and possible Radiation. I surely don't like the ADT.. Any thoghts
ChristopherH
in
Advanced Prostate Cancer
5 months ago
At the crossroads (again)
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
My profile is up to date, but, briefly, have failed chemo, ADT (am castrate resistant), failed Keytruda and now Pluvicto. Scans yest. & today show progression along with PSA rise. All my mets are in bone. So, my SOC choices are cabazataxel or radium 223. Other options are trial, which are a crapshoot
rsgdmd
in
Advanced Prostate Cancer
5 months ago
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